Results 111 to 120 of about 4,192 (239)

Inroads into epilepsy through high‐frequency oscillations: Achievements and benchmark areas for improvement

Epilepsia, EarlyView.
Abstract High‐frequency oscillations (HFOs) were discovered more than 20 years ago, and since then they have been studied intensively in the context of epilepsy. HFOs encompass a broad spectrum of oscillations, typically ranging from 80 Hz to several kHz, that include both normal and pathological oscillations, documented in people with epilepsy and ...
Christos Panagiotis Lisgaras, Birgit Frauscher, Jean Gotman, Julia Jacobs, Philippe Kahane, Richard J. Staba, Maeike Zijlmans   +6 more
wiley   +1 more source

A practical approach to in-hospital management of new-onset refractory status epilepticus/febrile infection related epilepsy syndrome

Frontiers in Neurology, 2023
New-onset refractory status epilepticus (NORSE) is “a clinical presentation, not a specific diagnosis, in a patient without active epilepsy or other preexisting relevant neurological disorder, with new onset of refractory status epilepticus without a ...
Zubeda Sheikh, Zubeda Sheikh, Lawrence J. Hirsch   +2 more
doaj   +1 more source

Anxiety-like behavior of prenatally stressed rats is associated with a selective reduction of glutamate release in the ventral hippocampus [PDF]

, 2012
Abnormalities of synaptic transmission and plasticity in the hippocampus represent an integral part of the altered programming triggered by early life stress.
Bouwalerh, H., Maccari, S., Mairesse, J., Marrocco, J., Morley-Fletcher, S., Ngomba, R.T., Nicoletti, F., Pittaluga, A., Silletti, V., Summa, M., Van Camp, G.   +10 more
core   +1 more source

Long Term outcomes after NORSE: Treatment with Vagus Nerve Stimulation [PDF]

, 2022
New-onset refractory status epilepticus (NORSE) is associated with high mortality, therapy resistant epilepsy (TRE) and poor cognitive and functional outcomes.
Burneo, Jorge G., Espino, Poul H., Gofton, Teneille, MacDougall, Keith, Moscol, Gaby, Suller-Marti, Ana   +5 more
core   +2 more sources

Evolution of the European Medicines Agency clinical guidelines for epilepsy drug development between 2010 and 2025: A comparative analysis by the ILAE Task Force on Regulatory Affairs

Epilepsia, EarlyView.
Abstract Objective The latest European Medicines Agency (EMA) guideline on the clinical investigation of medicines to treat epileptic disorders was adopted by the EMA Committee for Medicinal Products for Human Use in 2025. We compared this guideline with the previous version (2010), highlighting areas where significant revisions were introduced ...
Stéphane Auvin, Alexis Arzimanoglou, Jacqueline French, Kelly G. Knupp, Lieven Lagae, Eugen Trinka, Dennis Dlugos, Emilio Perucca   +7 more
wiley   +1 more source

Risk factors for super-refractory and mortality in generalized convulsive status epilepticus: a 10-year retrospective cohort study

Therapeutic Advances in Neurological Disorders, 2023
Background: Generalized convulsive status epilepticus (GCSE) is one of the most challenging life-threatening neurological emergencies. If GCSE becomes super-refractory, it is associated with significant mortality.
Dongmei Wang, Meirong Li, Yue Pan, Zhenzhou Lin, Zhong Ji, Xiaomei Zhang, Miaoqin Tan, Suyue Pan, Yongming Wu, Shengnan Wang   +9 more
doaj   +1 more source

Managing Refractory Status Epilepticus with Early Ketamine Administration [PDF]

, 2023
Status epilepticus is a time-sensitive neurological emergency that can be associated with severe disability and mortality. Approximately 20% of patients with status epilepticus will fail to respond to existing first and second-line therapies that act on ...
Shavers, Ashlyn
core   +1 more source

KCNJ4 variants disrupt inward‐rectifier potassium channel function and cause refractory epilepsy

Epilepsia, EarlyView.
Abstract Objective Epilepsy is a common neurological disorder with a strong genetic basis, most frequently arising from ion channel dysfunction. Although multiple inwardly rectifying potassium (Kir) channels have been implicated in epileptogenesis, the contribution of KCNJ4, which encodes the Kir2.3 channel, has not previously been established in human
Hu Pan, Deng Liu, Wuhen Xu, Yang Li, Juanli Hu, Oppermann Henry, Alexander Fuchs, Rami Abou Jamra, Zhen Liu, Mei He, Yuanlu Chen, Shengnan Wu, Xiaohuan Dong, Yiqiao Chen, Pengchao Wang, Weiyue Gu, Han Jing, Yabing Tang, Ya‐Jie Wang, Xiao Mao, Neng Xiao   +20 more
wiley   +1 more source

Fever related super-refractory status epilepticus: An adulthood presentation of a novel POLG variant: A case report [PDF]

, 2022
Deepak Menon, Sandeep Marasakatla, Vikram V. Holla, Nitish Kamble, M Netravathi, Pramod Kumar Pal   +5 more
openalex   +1 more source

Patterns of seizure frequency reduction in clinical trial participants with lower baseline seizure frequency

Epilepsia, EarlyView.
Abstract Objective Inclusion and exclusion criteria of clinical trials for seizures aim to select representative participants with a high enough seizure frequency to evaluate the efficacy of treatment in a relatively short double‐blind period. To inform the selection of seizure frequency‐based inclusion criteria, we evaluated the association between ...
Wesley T. Kerr, Advith S. Reddy, Neo Kok, Katherine N. McFarlane, Lavanya Biju, Jacqueline A. French   +5 more
wiley   +1 more source