Results 121 to 130 of about 4,192 (239)

Effect of Intravenous Phenobarbital on Left Ventricular Myocardial Contractility Determined by Echocardiography in Children [PDF]

, 2019
Introduction. Animal studies and rare human studies have suggesteda negative effect of barbiturates on cardiac function. Althoughintravenous (IV) phenobarbital is used routinely in children in theclinical setting, studies in children are lacking.
Amre, Devendra, Balaguru, Duraisamy, Doshi, Arpan R., Erikson, Christain, Malhotra, Monesha Gupta   +4 more
core   +2 more sources

Ranking of antiseizure medications in a panel of focal seizure models predicts their comparative efficacy in clinical add‐on trials in drug‐resistant focal epilepsy

Epilepsia, EarlyView.
Abstract Objective Most antiseizure medications (ASMs) have been discovered by testing in animal models, which are generally thought to predict antiseizure activity in patients. However, it is not known whether any of these models (or a combination of models) can predict whether a novel ASM exhibits higher clinical efficacy in focal drug‐resistant ...
Wolfgang Löscher, Pavel Klein
wiley   +1 more source

Unique deficits in place coding across subfields of the hippocampus in a mouse model of temporal lobe epilepsy

Epilepsia, EarlyView.
Abstract Objective Memory problems are comorbid with temporal lobe epilepsy (TLE). Animal models of TLE reveal impairments in spatial firing fields of hippocampal place cells, providing a potential neural substrate for memory problems. Each subfield of the hippocampus carries out unique aspects of spatial memory, yet little is known about how ...
Brittney L. Boublil, Margaret M. Donahue, Cathy B. Dang, Gergely Tarcsay, Laura A. Ewell   +4 more
wiley   +1 more source

Status epilepticus: Updates on mechanisms and treatments

Epilepsia Open, EarlyView.
Abstract Status epilepticus (SE) consists of prolonged, self‐sustaining seizures and is a common neurological emergency that causes respiratory compromise and neuronal injury. Without prompt treatment, the seizures can become resistant to benzodiazepines, leading to the progressive evolution of established, refractory, and super‐refractory SE.
Suchitra Joshi, Jaideep Kapur
wiley   +1 more source

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Rapid recovery after intrathecal dexamethasone in FIRES

Epileptic Disorders, EarlyView.
João Filipe Nico, Ana Rita Fradique, Catarina Teixeira, Rita Moinho, Mariana Leitão Marques, Constança Santos, Joana Afonso Ribeiro, Filipe Palavra, Cristina Pereira   +8 more
wiley   +1 more source

Global disparities in the recognition, diagnosis, and management of seizures or epilepsy of autoimmune etiology

Epilepsia Open, EarlyView.
Abstract Objective Despite advancements in “autoimmune epilepsy,” more accurately referred to herein as seizures or epilepsy of autoimmune etiology, significant variability exists in its recognition, diagnosis, and management internationally. This study assessed clinicians' understanding, access to diagnostic tools, and treatment practices across ...
Emily Guarasci, Robyn Whitney, Adrian Budhram, Maryam Nabavi Nouri   +3 more
wiley   +1 more source

Expanding the scope of pediatric epilepsy surgery: Access, indications, and outcomes in a modern cohort

Epilepsia Open, EarlyView.
Abstract Objective Expanded indications, diagnostic tools, and treatment options have transformed the landscape of modern pediatric epilepsy surgery. Published real‐world experiences from large surgical cohorts are still needed. To close this gap, we evaluated access, indications, treatment, and outcomes in a contemporary pediatric epilepsy surgery ...
John R. McLaren, William Muñoz, Hunki Kwon, Alexandra L. Geffrey, Pranav Nanda, Ronald Thibert, Lily Grossmann, Steven Stufflebeam, Camilo Jaimes, Britt Carlson Emerton, Kristopher T. Kahle, R. Mark Richardson, Catherine J. Chu   +12 more
wiley   +1 more source

Distinct clinical clusters of paediatric patients with status epilepticus: Retrospective cohort study

Developmental Medicine &Child Neurology, EarlyView.
Large Swiss cohort of paediatric status epilepticus demonstrates that treatment delay (> 60 min) directly contributes to morbidity. Machine‐learning analysis of routine clinical data identifies three distinct patient clusters: febrile status epilepticus, severe para‐infectious status epilepticus, and status epilepticus in children with known epilepsy ...
Richard J Burman, Anne Steinberg, Jamie Norris, Giorgio Selmin, Tommaso Fedele, Richard E Rosch, Georgia Ramantani   +6 more
wiley   +1 more source

An international survey of the relatives and friends of electroconvulsive therapy recipients

Psychology and Psychotherapy: Theory, Research and Practice, EarlyView.
Abstract Objectives This study aimed to address the paucity of studies of the relatives and friends of electroconvulsive therapy (ECT) patients. Methods A total of 1144 people responded to an online survey. Results The respondents included 286 relatives and friends of ECT recipients, from 22 countries.
Christopher Harrop, Sue Cunliffe, Sarah Price Hancock, Lucy Johnstone, Lisa Morrison, John Read   +5 more
wiley   +1 more source