Febrile infection-related epilepsy syndrome in childhood: A clinical review and practical approach [PDF]
, 2023 Febrile infection-related epilepsy syndrome (FIRES) of unknown aetiology is an extremely rare but severe epilepsy syndrome. It is characterized by a nonspecific febrile infection a few days before the onset of super-refractory status epilepticus ...
Baalen, Andreas van
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Interleukin-1 in Febrile Infection-Related Epilepsy Syndrome [PDF]
Annals of Child Neurology, 2023 Febrile infection-related epilepsy syndrome (FIRES) characteristically affects previously healthy children, who experience a sudden and explosive onset of super-refractory status epilepticus preceded by febrile infection and accompanied by fulminant ...
Joon Won Kang, Sookyong Koh
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MicroRNAs in the pathophysiology and treatment of status epilepticus [PDF]
, 2013 MicroRNA (miRNA) are an important class of non-coding RNA which function as post-transcriptional regulators of gene expression in cells, repressing and fine-tuning protein output.
Henshall, David C
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Super Refractory Status Epilepticus
, 2017 Earlier definitions of status epilepticus (SE) were based on the duration of seizures, but newer definitions rely more on a pragmatic staging based on treatment failures (Table 23.1). Refractory status epilepticus (RSE) is defined as SE that continues despite administration of both benzodiazepines and an appropriately dosed second-line antiseizure drug.
Zachariah, Joseph +2 more
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Pediatric super‐refractory status epilepticus treated with allopregnanolone [PDF]
Annals of Neurology, 2014 Super‐refractory status epilepticus is a life‐threatening condition. Resistance to benzodiazepine and barbiturate treatment for this disorder is thought to be due to internalization of synaptic γ‐aminobutyric acid (GABA)Areceptors, and withdrawal of benzodiazepines and barbiturates during treatment often triggers seizure recurrence.
Broomall, Eileen +8 more
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Super-Refractory Status Epilepticus: An Atypical Presentation and Case-Based Review
Archives of Epilepsy, 2015 Super-refractory status epilepticus is known to typically arise either from a distinct underlying cause or, in patients with no history of epilepsy, from no overt cause.
Chiazor Udochukwu ONYIA +4 more
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Immunity and inflammation in status epilepticus and its sequelae: possibilities for therapeutic application. [PDF]
, 2015 Status epilepticus (SE) is a life-threatening neurological emergency often refractory to available treatment options. It is a very heterogeneous condition in terms of clinical presentation and causes, which besides genetic, vascular and other structural ...
Dingledine, R. +2 more
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Refractory Status Epilepticus in Genetic Epilepsy-Is Vagus Nerve Stimulation an Option? [PDF]
, 2020 Refractory and super-refractory status epilepticus (RSE, SRSE) are severe conditions that can have long-term neurological consequences with high morbidity and mortality rates.
Calabrese, Costanza +9 more
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Treatment of early life status epilepticus: What can we learn from animal models? [PDF]
, 2018 Treatment of status epilepticus (SE) in infants and children is challenging. There is a recognition that a broad set of developmental processes need to be considered to fully appreciate the physiologic complexity of severe seizures, and seizure outcomes,
Suchomelova, Lucie +2 more
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Super refractory seizures with autoimmune encephalitis and ventilator associated pneumonia: a case report [PDF]
, 2021 Autoimmune encephalitis is an immune-mediated syndrome with sub-acute to chronic presentations, such as memory impairment, altered sensorium, behavioral abnormality, psychosis, and seizures.
Fardan, Mohammed +3 more
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