Results 71 to 80 of about 3,556,805 (146)

Burden of illness for super-refractory status epilepticus patients [PDF]

Journal of Medical Economics, 2016
To provide an estimate of the annual number of super-refractory status epilepticus (SRSE) cases in the US and to evaluate utilization of hospital resources by these patients.The Premier Hospital Database was utilized to estimate the number of SRSE cases based on hospital discharges during 2012.
Jamil M. Beg, Thomas D. Anderson, Kevin Francis, Lisa M. Meckley, David Fitzhenry, Todd Foster, Susheel Sukhtankar, Stephen J. Kanes, Lidia M. V. R. Moura   +8 more
openaire   +2 more sources

p‐Brain: A Modular Open‐Source Framework for Automated Quantitative DCE‐MRI of Cerebral Perfusion, Microvasculature, and Blood–Brain Barrier Permeability

Magnetic Resonance in Medicine, Volume 96, Issue 6, Page 2601-2614, December 2026.
ABSTRACT We present p‐Brain, a modular, open‐source framework for reproducible, automated quantitative DCE‐MRI at scale. Rather than a fixed pipeline, p‐Brain is built from interchangeable stages (ingestion, T1/M0$$ {T}_1/{M}_0 $$ fitting, vascular and tissue ROI extraction, signal‐to‐concentration conversion, kinetic modeling, and quality control ...
Edis D. Tireli, Stig P. Cramer, Ulrich Lindberg, Derya Tireli, Mark B. Vestergaard, Henrik B. W. Larsson   +5 more
wiley   +1 more source

Brexanolone as adjunctive therapy in super‐refractory status epilepticus [PDF]

Annals of Neurology, 2017
ObjectiveSuper‐refractory status epilepticus (SRSE) is a life‐threatening form of status epilepticus that continues or recurs despite 24 hours or more of anesthetic treatment. We conducted a multicenter, phase 1/2 study in SRSE patients to evaluate the safety and tolerability of brexanolone (USAN; formerly SAGE‐547 Injection), a proprietary, aqueous ...
Eric S. Rosenthal, Jan Claassen, Mark S. Wainwright, Aatif M. Husain, Henrikas Vaitkevicius, Shane Raines, Ethan Hoffmann, Helen Colquhoun, James J. Doherty, Stephen J. Kanes   +9 more
openaire   +2 more sources

Surgical management of status epilepticus: A systematic review

Epilepsia Open
Status Epilepticus (SE), unresponsive to medical management, is associated with high morbidity and mortality. Surgical management is typically considered in these refractory cases. The best surgical approach for affected patients remains unclear; however,
Rohan Jha, Sarah E. Blitz, Melissa M. J. Chua, Aaron E. L. Warren, Jong Woo Lee, John D. Rolston   +5 more
doaj   +1 more source

Developmental and Epileptic Encephalopathy due to Biallelic Pathogenic Variants in PIGM

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1759-1771, September 2026.
ABSTRACT Objective PIGM encodes a critical enzyme in the glycosylphosphatidylinositol (GPI)‐anchor biosynthesis pathway. While promoter‐region mutations in PIGM have been associated with a relatively mild phenotype characterized by portal vein thrombosis and absence seizures, recent evidence suggests that coding‐region mutations result in a more severe
Júlia Sala‐Coromina, Anna Marcé‐Grau, Barbara Masotto, Marta Codina, Lamia BenJemaa, Yasmina Elaribi, Mónica Martinez‐Gallo, Roger Colobran, Angel Sanchez‐Montañez, Irene Valenzuela, Yoshiko Murakami, Alfons Macaya   +11 more
wiley   +1 more source

Efficacy of lacosamide in neonatal‐onset super‐refractory status epilepticus: a case report

, 2021
: We report the case of a previously healthy newborn who developed super-refractory status epilepticus after Group B streptococcal meningoencephalitis.
Veronica Bertozzi, Clarissa Tona, Gaia Biscalchin, Tona, Clarissa, Stefano Sartori, Biscalchin, Gaia, Bertozzi, Veronica, Sartori, Stefano, Bonardi, Claudia M, Claudia M. Bonardi, Angela Amigoni, Amigoni, Angela   +11 more
core   +1 more source

Vagus nerve stimulation in super-refractory status epilepticus following hypoxic brain injury: a case report and review of the literature

Interdisciplinary Neurosurgery
Background: Status epilepticus (SE) is a life-threatening neurological condition that can be resistant to pharmacological treatments, particularly when triggered by severe brain insults such as asphyxia.
Farzan Fahim, Mahdi Mehmandoost, Faezeh Mousavinia, Amirmohammad Bahri, Negin Safari Dehnavi, Almirabbas Rouholamini, Omidreza Nikbakhtamirabad, Parisa Nikbakhtamirabad, Diba Akbarzadeh, Sayeh Oveisi, Yousef Moghadasi, Alireza Zali, Bijan Herfedoustbiazar   +12 more
doaj   +1 more source

Surgical treatment of focal symptomatic refractory status epilepticus with and without invasive EEG

Epilepsy and Behavior Case Reports, 2015
Purpose: Neurosurgery appears to be a reasonable alternative in carefully selected patients with refractory status epilepticus (RSE) and super-refractory status epilepticus (SRSE).
Carolina Cuello Oderiz, Marina Aberastury, Ana Gabriela Besocke, Jorge Sinner, Betiana Comas-Guerrero, Carlos Alberto Ciraolo, Maria Concepción Pasteris, Walter Horacio Silva, María del Carmen García   +8 more
doaj   +1 more source

Claustrum Involvement in New Onset Refractory Status Epilepticus: A Systematic Review

Annals of Clinical and Translational Neurology, Volume 13, Issue 9, Page 1750-1758, September 2026.
ABSTRACT The claustrum sign is a distinctive neuroimaging finding characterized by bilateral T2/FLAIR hyperintensity of the claustrum, one of the most interconnected regions of the human brain. It was first described in new‐onset refractory status epilepticus (NORSE) and febrile infection–related epilepsy syndrome (FIRES).
Margherita Burani, Lorenzo Muccioli, Giada Giovannini, Niccolò Orlandi, Francesca Bisulli, Stefano Meletti   +5 more
wiley   +1 more source

Fatty Acid Binding Protein 5 Mediates Astrocytic Pyroptosis and Neuroinflammation in Epilepsy via cGAS/STING Pathway

Advanced Science, Volume 13, Issue 53, 24 September 2026.
Astrocytic FABP5 promotes mitochondrial stress, cGAS‐STING pathway activation, pyroptosis, and neuroinflammation in epilepsy, contributing to seizure pathology. Genetic targeting of FABP5 or pharmacological inhibition of STING alleviates epileptic phenotypes, highlighting a potential therapeutic strategy for epilepsy.
Chen Chen, Yao Zhao, Yangye Lian, Yifei Hou, Lifen Gong, Tingting Wu, Yulin Yang, Jiaqi Zhu, Xin Wang, Kaihua Zhang, Jing Ding   +10 more
wiley   +1 more source