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Otolaryngologic Clinics of North America, 2010
Superantigens (SAgs) are derived from diverse sources, including bacteria, viruses, and human hepatic tissue. SAgs initially cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune tolerance. They can also act as superallergens by stimulating a broad spectrum of mast cells and basophils in patients with allergic ...
Stow, Nicholas W. +3 more
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Superantigens (SAgs) are derived from diverse sources, including bacteria, viruses, and human hepatic tissue. SAgs initially cause lymphocyte activation but then result in clonal deletion and anergy, leading to immune tolerance. They can also act as superallergens by stimulating a broad spectrum of mast cells and basophils in patients with allergic ...
Stow, Nicholas W. +3 more
openaire +3 more sources
The bacterial superantigen and superantigen‐like proteins
Immunological Reviews, 2008Summary: The bacterial superantigens are protein toxins that bind to major histocompatibility complex class II and T‐cell receptor to stimulate large numbers of T cells. The majority are produced by the Gram‐positive organisms Staphylococcus aureus and Streptococcus pyogenes and are the causative agents in toxic shock syndrome, an acute disease caused
John D, Fraser, Thomas, Proft
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Cell Biophysics, 1993
The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent activator of T lymphocytes when presented on MHC class II antigens. In order to induce T lymphocytes to reject a tumor, we substituted the specificity of SEA for MHC class II molecules with specificity for tumor cells by combining SEA with a MAb recognizing colon ...
T, Kalland +8 more
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The bacterial superantigen staphylococcal enterotoxin A (SEA) is an extremely potent activator of T lymphocytes when presented on MHC class II antigens. In order to induce T lymphocytes to reject a tumor, we substituted the specificity of SEA for MHC class II molecules with specificity for tumor cells by combining SEA with a MAb recognizing colon ...
T, Kalland +8 more
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Journal of the American Academy of Dermatology, 2011
Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs.
Edgar S, Macias +3 more
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Superantigens (SAgs) are virulent polypeptides that are produced by a variety of infectious organisms. They are capable of causing nonspecific T cell activation by circumventing normal antigen processing in the human host. The genetic makeup of the host plays a role in conferring susceptibility or protection against SAgs.
Edgar S, Macias +3 more
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Immunological Investigations, 1997
Superantigens comprise a large group of viral and bacterial proteins that stimulate T lymphocyte proliferation without regard for the antigenic specificity of the T cells but dependent on the composition of the variable part of the beta chain of the T cell receptor.
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Superantigens comprise a large group of viral and bacterial proteins that stimulate T lymphocyte proliferation without regard for the antigenic specificity of the T cells but dependent on the composition of the variable part of the beta chain of the T cell receptor.
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2007
Superantigens (SAgs) are the most powerful T cell mitogens ever discovered. They activate the immune system by binding to the major histocompatibility complex (MHC) class II and T cell receptor molecules. One of the major producers of SAgs is Streptococcus pyogenes, or group A streptococcus (GAS).
Thomas, Proft, John D, Fraser
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Superantigens (SAgs) are the most powerful T cell mitogens ever discovered. They activate the immune system by binding to the major histocompatibility complex (MHC) class II and T cell receptor molecules. One of the major producers of SAgs is Streptococcus pyogenes, or group A streptococcus (GAS).
Thomas, Proft, John D, Fraser
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Current Opinion in Structural Biology, 1995
Bacterial superantigens are extremely potent activators of the immune system. Their ability to efficiently cross-link molecules of the major histocompatibility complex class II and T-cell receptors causes the normal antigen specificity of each receptor to be bypassed.
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Bacterial superantigens are extremely potent activators of the immune system. Their ability to efficiently cross-link molecules of the major histocompatibility complex class II and T-cell receptors causes the normal antigen specificity of each receptor to be bypassed.
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Superantigens: Supersignalers?
Science's STKE, 2006Some bacterial and viral proteins are potent activators of the immune response, earning them the title of superantigens (SAgs). Infection with pathogens containing these proteins can produce massive T cell activation and can result in various potentially fatal conditions, such as toxic shock and food poisoning.
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2003
This chapter describes a quantitative assay for the streptococcal superantigen, streptococcal pyrogenic exotoxin A (SPEA), which can be used in broth, tissue-culture media, and certain sera. The protocol can be adapted to allow measurement of any bacterial superantigen or protein toxin, using different oligonucleotides to amplify the coding sequences ...
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This chapter describes a quantitative assay for the streptococcal superantigen, streptococcal pyrogenic exotoxin A (SPEA), which can be used in broth, tissue-culture media, and certain sera. The protocol can be adapted to allow measurement of any bacterial superantigen or protein toxin, using different oligonucleotides to amplify the coding sequences ...
openaire +2 more sources