Results 31 to 40 of about 50,801 (153)
Frontiers in Neuroscience, 2014 Axonal transport deficits have been reported as an early pathology in several neurodegenerative disorders, including glaucoma. However, the progression and mechanisms of these deficits are poorly understood.
Christine M Dengler-Crish +8 more
doaj +1 more source
Superiorization of Incremental Optimization Algorithms for Statistical Tomographic Image Reconstruction [PDF]
, 2016 We propose the superiorization of incremental algorithms for tomographic image reconstruction. The resulting methods follow a better path in its way to finding the optimal solution for the maximum likelihood problem in the sense that they are closer to the Pareto optimal curve than the non-superiorized techniques.
arxiv +1 more source
Experimental Physiology, EarlyView.Abstract Moderate and acute intermittent hypoxia (IH) facilitates respiration in adults, mostly by recruiting peripheral chemo‐/baroreceptors. As central chemoreceptors are widely expressed in immature brains, we hypothesized that IH modulates respiration at birth through a purely neurogenic mechanism involving the hypothalamus.
Rosamaria Apicella +2 more
wiley +1 more source
Hydrocephalus caused by conditional ablation of the
Cerebrospinal Fluid Research, 2008 To investigate the roles of Pten and β-Catenin in the midbrain, either the Pten gene or the β-catenin gene was conditionally ablated, using Dmbx1 (diencephalon/mesencephalon-expressed brain homeobox gene 1)-Cre mice.
Ohtoshi Akihira
doaj +1 more source
A Direct Approach to Simultaneous Tests of Superiority and Noninferiority with Multiple Endpoints [PDF]
arXiv, 2023 Simultaneous tests of superiority and non-inferiority hypotheses on multiple endpoints are often performed in clinical trials to demonstrate that a new treatment is superior over a control on at least one endpoint and non-inferior on the remaining endpoints.
arxiv
Acta Physiologica, Volume 241, Issue 5, May 2025.Abstract Aim Because of their stable expression, some EF‐hand Ca2+‐binding proteins are broadly used as histochemical markers of neurons in the nervous system. Secretagogin is a member of “neuron‐specific” Ca2+‐sensor proteins, yet variations in its expression due, chiefly, to neuronal activity remain ambiguous.
János Hanics +7 more
wiley +1 more source
Deficits in the activation of human oculomotor nuclei in chronic traumatic brain injury
Frontiers in Neurology, 2015 Binocular eye movements form a finely-tuned system that requires accurate coordination of the oculomotor dynamics of the brainstem control nuclei when tracking the fine binocular disparities required for 3D vision.
Christopher W Tyler +3 more
doaj +1 more source
Movement Disorders, Volume 40, Issue 4, Page 716-726, April 2025.Abstract Background Central synucleinopathies, including Parkinson's disease (PD), dementia with Lewy bodies (DLB), and multiple system atrophy (MSA), involve alpha‐synuclein accumulation and dopaminergic cell loss in the substantia nigra (SN) and locus coeruleus (LC).
Paula Trujillo +10 more
wiley +1 more source
Superiorization as a novel strategy for linearly constrained inverse radiotherapy treatment planning [PDF]
arXiv, 2022 We apply the superiorization methodology to the intensity-modulated radiation therapy (IMRT) treatment planning problem. In superiorization, linear voxel dose inequality constraints are the fundamental modeling tool within which a feasibility-seeking projection algorithm will seek a feasible point. This algorithm is then perturbed with gradient descent
arxiv
Glaucoma animal models in rabbits: State of the art and perspectives—A review
Animal Models and Experimental Medicine, Volume 8, Issue 3, Page 429-440, March 2025.Glaucoma, a visual thief, is characterized by elevated intraocular pressure (IOP) and loss of retinal ganglion cells (RGCs). Selecting suitable animals for preclinical models is of great significance in research on the prevention, early screening, and effective treatments of glaucoma.
Rong Hu +4 more
wiley +1 more source