Results 111 to 120 of about 735,827 (347)

Topology of Superoxide Production from Different Sites in the Mitochondrial Electron Transport Chain*

Journal of Biological Chemistry, 2002
We measured production of reactive oxygen species by intact mitochondria from rat skeletal muscle, heart, and liver under various experimental conditions.
J. St-Pierre, Julie A. Buckingham, Stephen J Roebuck, M. Brand   +3 more
semanticscholar   +1 more source

Antioxidant and Anti‐Senescence Polyvinyl Alcohol‐Gallic Acid Supramolecular Hydrogels for Stem Cell Culture

Advanced Healthcare Materials, EarlyView.
The PVA‐GA hydrogel is formed through hydrogen bonding between PVA hydroxyl groups and GA galloyl units, enabling sustainable GA release and its extended biological activity. The hydrogel scavenges ROS to reduce oxidative stress, preventing mitochondrial damage from excessive ROS, mitigating hADSC senescence, and preserving VEGF secretion, offering a ...
Yiduo Zhou, Matías L. Picchio, Yan Nie, Lei Wang, Oihane Sanz, Yue Liu, Xun Xu, Lukas Prantl, Oliver Felthaus, Weiwei Wang, Marcelo Calderón, Nan Ma   +11 more
wiley   +1 more source

“Therapies Through Gut:” Targeted Drug Delivery for Non‐Gastrointestinal Diseases by Oral Administration

Advanced Healthcare Materials, EarlyView.
Schematic illustration of the mechanism of targeted delivery of nanoparticles including 1) paracellular, 2) endolysosomal escape, 3) receptor mediated endocytosis, and 4) M cell mediated transport for non‐GI diseases by oral administration such as atherosclerosis, cancer, diabetes, and brain diseases. Abstract Oral drug delivery is a promising approach
Subarna Ray, Shehzahdi S. Moonshi, Hang Thu Ta   +2 more
wiley   +1 more source

Hypercholesterolemia increases endothelial superoxide anion production.

Journal of Clinical Investigation, 1993
Indirect evidence suggests accelerated degradation of endothelium-derived nitric oxide (ENDO) by superoxide anion (O2-) in hypercholesterolemic vessels (HV). To directly measure O2- production by normal vessels (NV) and HV, we used an assay for O2- based
Y. Ohara, T. Peterson, D. Harrison
semanticscholar   +1 more source

Radiation‐Resistant Bacteria Deinococcus radiodurans‐Derived Extracellular Vesicles as Potential Radioprotectors

Advanced Healthcare Materials, EarlyView.
Deinococcus radiodurans‐derived extracellular vesicles (R1‐EVs) provide radioprotection against total‐body irradiation‐induced acute radiation syndrome in mice. R1‐EVs mitigate oxidative damage by scavenging free radicals, promoting intestinal repair, enhancing hematopoietic function, and modulating immune responses. This study highlights the potential
Jeong Moo Han, Godfrey Mwiti, Seo‐Joon Yeom, Jaeyoon Lim, Woo Sik Kim, Sangyong Lim, Seung‐Taik Lim, Eui‐Baek Byun   +7 more
wiley   +1 more source

Interaction between Vitamins C and E When Scavenging the Superoxide Radical Shown by Hydrodynamic Voltammetry and DFT

Biophysica
In this study, we examine the cooperative effect between vitamins C and E that mitigates oxidative stress by using experimental and computational methods.
Francesco Caruso, Jens Z. Pedersen, Sandra Incerpi, Stuart Belli, Raiyan Sakib, Miriam Rossi   +5 more
doaj   +1 more source

The influence of reactive oxygen species on local redox conditions in oxygenated natural waters

Frontiers in Earth Science, 2016
Redox conditions in natural waters are a fundamental control on biogeochemical processes and ultimately many ecosystem functions. While the dioxygen/water redox couple controls redox thermodynamics in oxygenated aquatic environments on geological ...
Andrew Rose
doaj   +1 more source

Synthetic Bilirubin‐Based Nanomedicine Protects Against Renal Ischemia/Reperfusion Injury Through Antioxidant and Immune‐Modulating Activity

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
BX‐001N, a polyethylene glycol‐conjugated bilirubin 3α nanoparticle, is the first GMP‐grade, synthetic bilirubin‐based nanomedicine. It effectively attenuates acute renal injury, facilitates subacute renal recovery, and suppresses chronic fibrosis after renal ischemia/reperfusion injury via anti‐oxidant and immune‐modulating activity.
Ji‐Jing Yan, Hyunjin Kim, Bomin Kim, Honglin Piao, Joon Young Jang, Tae Kyeom Kang, Wook‐Bin Lee, Dohyeon Kim, Seunghyun Jo, Duckhyang Shin, Sharif MD Abuzar, Myung L. Kim, Jaeseok Yang, Sangyong Jon   +13 more
wiley   +1 more source

Bioactive Secondary Metabolites of a Marine Bacillus sp. Inhibit Superoxide Generation and Elastase Release in Human Neutrophils by Blocking Formyl Peptide Receptor 1

Molecules, 2013
It is well known that overwhelming neutrophil activation is closely related to acute and chronic inflammatory injuries. Formyl peptide receptor 1 (FPR1) plays an important role in activation of neutrophils and may represent a potent therapeutic target in
Yin-Ting Huang, Tsong-Long Hwang, Pei-Jen Chung, Jimmy Kuo, Shun-Chin Yang, Wen-Yi Chang, Chwan-Fwu Lin   +6 more
doaj   +1 more source

Superoxide and superoxide dismutase in red blood cells.

The St. Luke's Hospital gazette, 1976
In 1969 a previously obscure copper protein of red blood cells, erythrocuprein, was shown to catalyse the dismutation of superoxide radicals. Erythrocuprein thus became superoxide dismutase and the object of intensive study. Superoxide dismutase is typically an enzyme of aerobic organisms which utilize oxygen as the major electron acceptor.
Anastasi, Angela, Bannister, J. V., Bannister, William H.   +2 more
openaire   +2 more sources