Results 121 to 130 of about 318,307 (167)
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Superoxide interaction with nickel and iron superoxide dismutases
Journal of Molecular Graphics and Modelling, 2009Interaction of superoxide with the metal active sites of nickel and iron-containing superoxide dismutases is investigated with density functional theory. Outer-sphere mechanisms for both the reduction and oxidation of superoxide are proposed to be the common feature of these structurally unrelated SODs.
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Superoxide, superoxide dismutase and ischemic injury.
Current opinion in investigational drugs (London, England : 2000), 2002Oxidative stress results from an oxidant/antioxidant imbalance: an excess of oxidants relative to the antioxidant capacity. Recent evidence strongly suggests that oxidant stress plays a major role in several aspects of ischemia and reperfusion. Immunohistochemical and biochemical evidence demonstrate the significant role of reactive oxygen species, in ...
Salvemini, Daniela, CUZZOCREA, Salvatore
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SUPEROXIDE RADICALS, SUPEROXIDE DISMUTASES AND THE AEROBIC LIFESTYLE
Photochemistry and Photobiology, 1978Abstract— The superoxide radical (O‐2) is a commonplace product of the biological reduction of molecular oxygen and plays an important role in oxygen toxicity. Superoxide dismutases (SOD) catalytically scavenge this radical and are the primary defense against its cytotoxicity. The data which support these statements have been briefly reviewed.
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A superoxide dismutase-modified electrode that detects superoxide ion
Chemical Communications, 2002A superoxide dismutase (SOD)-modified electrode, in which SOD is oriented on the gold electrode via a self-assembled monolayer of cysteine so as to allow its direct electrode reaction, possesses a bi-directional electrocatalysis for both the oxidation of superoxide ion (O2-) to O2 and the reduction of O2- to H2O2 and functions as a third generation O2-
T.Ohsaka +4 more
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Superoxide-Superoxide Oxidoreductase Activity of the Captopril-Copper Complex
Archives of Medical Research, 2002The purpose of this study was to determine whether the interaction of captopril, an angiotensin-converting enzyme inhibitor, with copper could modify the superoxide dismutase activity of this metal. Results may help to explain the interaction of captopril with reactive oxygen species in the stunned myocardium where substantial mobilization of copper ...
David, Jay +4 more
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Superoxide constitutes a major signal of mitochondrial superoxide flash
Life Sciences, 2013Mitochondrial flashes detected with an N- and C-terminal circularly-permuted yellow fluorescent protein (cpYFP) have been thought to represent transient and quantal bursts of superoxide production under physiological, stressful and pathophysiological conditions.
Xing, Zhang +9 more
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Reductive elimination of superoxide: Structure and mechanism of superoxide reductases
Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2010Superoxide anion is among the deleterious reactive oxygen species, towards which all organisms have specialized detoxifying enzymes. For quite a long time, superoxide elimination was thought to occur through its dismutation, catalyzed by Fe, Cu, and Mn or, as more recently discovered, by Ni-containing enzymes.
Ana Filipa, Pinto +2 more
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Reactions of Superoxide with Myeloperoxidase
Biochemistry, 2007When neutrophils ingest bacteria, they discharge superoxide and myeloperoxidase into phagosomes. Both are essential for killing of the phagocytosed micro-organisms. It is generally accepted that superoxide is a precursor of hydrogen peroxide which myeloperoxidase uses to oxidize chloride to hypochlorous acid. Previously, we demonstrated that superoxide
Anthony J, Kettle +3 more
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Superoxide in the Vascular System
Journal of Vascular Research, 2002Oxidant production and regulation is becoming increasingly important in the study of vascular signaling mechanisms, and recent reviews have characterized some of the possible roles for known downstream products of superoxide formation. In this review, we will examine current research in the field, with a special emphasis on the role of the superoxide ...
Michael S, Wolin +2 more
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Development of a superoxide sensor by immobilization of superoxide dismutase
Sensors and Actuators B: Chemical, 2002Abstract Superoxide (O 2 − , one of the reactive oxygen species (ROS)) produced in vivo plays various pathphysiological and physiological roles, and thus it is of great importance and value to evaluate quantitatively dynamic changes in superoxide concentration. We thus aimed at developing a superoxide dismutase (SOD)-immobilized sensor.
Kosuke Endo +7 more
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