Results 171 to 180 of about 735,827 (347)

Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α

Advanced Science, EarlyView.
NEU1, a key regulator of glycolysis, is markedly upregulated following DOX treatment. This upregulation is attributed to HIF1α’s transcriptional repression, requiring intricate interactions with NRF2. Increased NEU1 facilitates SIRT1 lysosomal degradation, contributing to aberrant glycolytic phenotype and cardiac damage.
Ting Gao, Yufeng Tang, Tao Zeng, Jie Wang, Xiaohui Zhang, Qingbo Liu, Xun Guan, Xinyu Tang, Guangping Lu, Jiahao Li, Mingrui Liu, Dongmei Zhang, Sixuan Lv, Junlian Gu   +13 more
wiley   +1 more source

Commentary: Superoxide Generation and Its Involvement in the Growth of Mycobacterium smegmatis

Frontiers in Microbiology, 2017
Abhishek Mishra
doaj   +1 more source

Increased ROS and Persistent Pro-Inflammatory Responses in a Diabetic Wound Healing Model (db/db): Implications for Delayed Wound Healing. [PDF]

Int J Mol Sci
Elajaili H, Lyttle BD, Lewis CV, Bardill JR, Dee N, Seal S, Nozik ES, Liechty KW, Zgheib C.   +8 more
europepmc   +1 more source

Rational Design of MOF‐Based Multifunctional Bio‐Nanoreactor for Efficient Detection and Photo‐Degradation of Chloramphenicol

Advanced Science, EarlyView.
A multi‐functional photo‐enzymatic nanoreactor HRP@Fe‐NU‐1003 is developed through co‐immobilization of horseradish peroxidase and FeCl2 on a photosensitive metal–organic frameworks NU‐1003. This material showcases remarkable sensitivity and efficacy in both detecting and subsequently photo‐degrading chloramphenicol residues in food products.
Lu Ran, Niu Feng, Yiming Dong, Huanyu Cai, Yiping Chen, Huailong Teng   +5 more
wiley   +1 more source

An Electron Paramagnetic Resonance Study of the Superoxide-Scavenging and Redox-Modulating Effects of Lecithinized Superoxide Dismutase in the Bloodstream. [PDF]

Molecules
Lazarova D, Getsov P, Bakalova R, Nikolova B, Semkova S, Zhelev Z, Qiao Z, Ishikawa T, Fukuda K, Osada K, Mileva M, Mizushima T, Aoki I.   +12 more
europepmc   +1 more source

Metal–Organic Frameworks: Unlocking New Frontiers in Cardiovascular Diagnosis and Therapy

Advanced Science, EarlyView.
Metal–organic frameworks (MOFs), are composed of metal ions and bridging organic ligands, are recognized as an excellent platform for host‐gust chemistry. Its rich structural composition, modifiable sites, and multilevel pore distribution can provide delivery and release of signaling molecules, probes, and therapeutic drugs, which exhibit great medical
Qilu Wu, Yuxiao Feng, Mathilde Lepoitevin, Meng Yu, Christian Serre, Jun Ge, Yuan Huang   +6 more
wiley   +1 more source

Gα13 Promotes Clonogenic Growth by Increasing Tolerance to Oxidative Metabolic Stress in Prostate Cancer Cells. [PDF]

Int J Mol Sci
Wu D, Lim WK, Chai X, Seshachalam VP, Rasheed SAK, Ghosh S, Casey PJ.   +6 more
europepmc   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, EarlyView.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Norepinephrine promotes oxidative stress in vascular adventitial fibroblasts via PKC/NFκB-mediated NOX2 upregulation. [PDF]

Redox Rep
Wang YM, Dong HK, Dai M, Wang JX, Xu XY, Zhu GQ, Li XZ.   +6 more
europepmc   +1 more source

Ultrasound‐Responsive 4D Bioscaffold for Synergistic Sonopiezoelectric‐Gaseous Osteosarcoma Therapy and Enhanced Bone Regeneration

Advanced Science, EarlyView.
An acoustic‐responsive therapeutic platform for synergistic sonopiezoelectric‐gaseous osteosarcoma therapy and bone regeneration is fabricated through the joint loading of few‐layer black phosphorus nanosheets and S‐Nitroso‐L‐glutathione onto the 3D‐printed bioactive glass scaffolds.
Haoyu Fang, Daoyu Zhu, Yixuan Chen, Changqing Zhang, Gan Li, Qihang Fang, Meiqi Chang, Yu Chen, Youshui Gao   +8 more
wiley   +1 more source