Results 111 to 120 of about 402,173 (377)

From De Novo Conceived Small Molecules to Multifunctional Supramolecular Nanoparticles: Dual Biofilm and T3SS Intervention, Enhanced Foliar Affinity, and Effective Rice Disease Control

Advanced Science, EarlyView.
From de novo engineered bioactive molecules BtP27 to the multifunctional supramolecular material BtP27@β‐CD with a sunflower‐shaped morphology: its pragmatic applications in augmenting foliar affinity, disrupting biofilms and T3SS, and managing rice pathologies. Abstract Conventional antimicrobials typically exhibit suboptimal deposition on rice leaves,
Xianfu Mu, Kongjun Liu, Jinghan Yang, Juan Liu, Fengpei Du, Gefei Hao, Peiyi Wang   +6 more
wiley   +1 more source

Mas Signaling Potentiates Neutrophil Extracellular Traps Formation Induced by Endothelial Cells Derived S1P in Mice with Acute Liver Failure

Advanced Science, EarlyView.
In mice challenged with lipopolysaccharide/D‐galactosamine (L/G), Mas signaling increased SHP2 in hepatic Col4a1+ endothelial cells, inhibiting farnesoid X receptor (FXR), potentially due to enterogenic deoxycholic acid. This inhibition activates sphingosine‐1‐phosphate‐induced Raf/MEK/ERK signaling in Cldn1+CD177+ neutrophils, causing neutrophil ...
Bo Yang, Shuai Chen, Xiaoqi Xia, Ziwen Tao, Chun Liu, Shanshan Li, Shuo Zhang, Jiali Huang, Lu Xia, Wenqiang Quan, Changqing Yang, Jing Li   +11 more
wiley   +1 more source

Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils [PDF]

Neuroscience Research 41(3): 233-241 (2001), 2007
The time course of oxidative damage in different brain regions was investigated in the gerbil model of transient cerebral ischemia. Animals were subjected to both common carotid arteries occlusion for 5 min. After the end of ischemia and at different reperfusion times (2, 6, 12, 24, 48, 72, 96 h and 7 days), markers of lipid peroxidation, reduced and ...
arxiv  

Paclitaxel/Luteolin Coloaded Dual‐Functional Liposomes for Esophageal Cancer Therapy

Advanced Science, EarlyView.
The authors develop a pH‐sensitive aptamer‐modified liposome (EA2‐PSL‐PTX/LUT) to illustrate a strategy for the precise delivery of combinational chemotherapeutic drugs for esophageal squamous cell carcinoma (ESCC) targeted therapy. EA2‐PSL‐PTX/LUT provides efficient co‐loading, tumor targeting, and controlled release of luteolin and paclitaxel ...
Congyong Sun, Fei Xie, Huiyun Zhang, Lulu Feng, Yuting Wang, Chaofan Huang, Zhizhen Cui, Chao Luo, Li Zhang, Qilong Wang   +9 more
wiley   +1 more source

Selective vulnerability to kainate-induced oxidative damage in different rat brain regions [PDF]

Journal of Applied Toxicology 21(5): 403-407 (2001), 2007
Some markers of oxidative injury were measured in different rat brain areas (hippocampus, cerebral cortex, striatum, hypothalamus, amygdala/piriform cortex and cerebellum) after the systemic administration of an excitotoxic dose of kainic acid (KA, 9 mg kg(-1) i.p.) at two different sampling times (24 and 48 h).
arxiv  

Expression of wild-type human superoxide dismutase-1 in mice causes amyotrophic lateral sclerosis.

Human Molecular Genetics, 2013
A common cause of amyotrophic lateral sclerosis (ALS) is mutations in the gene encoding superoxide dismutase-1. There is evolving circumstantial evidence that the wild-type protein can also be neurotoxic and that it may more generally be involved in the ...
K. Graffmo, K. Forsberg, J. Bergh, A. Birve, P. Zetterström, P. Andersen, S. Marklund, T. Brännström   +7 more
semanticscholar   +1 more source

Orally Administered Functional Polyphenol‐Nanozyme‐Armored Probiotics for Enhanced Amelioration of Intestinal Inflammation and Microbiota Dysbiosis

Advanced Science, EarlyView.
This study presents a novel polyphenol‐nanozyme‐armored probiotic system (ECA@EcN) for enhanced treatment of inflammatory bowel disease (IBD). By integrating chitosan‐modified epigallocatechin gallate (EGCG‐CS) with gold nanozymes, the system effectively scavenges ROS, improves probiotic viability, and restores gut microbiota balance.
Yong Zhu, Ziqu Fang, Jie Bai, Longhui Wang, Jiaqing Chen, Zehua Zhang, Qiang Wang, Weiwei Sheng, Xueyin Pan, Zhenyuan Gao, Dengqiu Xu, Pengkai Wu, Beicheng Sun   +12 more
wiley   +1 more source

The mechanism of action of superoxide dismutase from pulse radiolysis and electron paramagnetic resonance. Evidence that only half the active sites function in catalysis [PDF]

, 1974
E.M. Fielden, Peter Roberts, Robert C. Bray, David J. Lowe, Gillian N. Mautner, Giuseppe Rotilio, Lilia Calabrese   +6 more
openalex   +1 more source

Cupric Yersiniabactin Is a Virulence-Associated Superoxide Dismutase Mimic

ACS Chemical Biology, 2013
Many Gram-negative bacteria interact with extracellular metal ions by expressing one or more siderophore types. Among these, the virulence-associated siderophore yersiniabactin (Ybt) is an avid copper chelator, forming stable cupric (Cu(II)-Ybt ...
K. S. Chaturvedi, C. Hung, D. Giblin, Saki Urushidani, Anthony M. Austin, M. Dinauer, J. P. Henderson   +6 more
semanticscholar   +1 more source

Simultaneous Monitoring of Tyrosinase and ATP in Thick Brain Tissues Using a Single Two‐Photon Fluorescent Probe

Advanced Science, EarlyView.
A single dual‐emission two‐photon fluorescent probe is designed for simultaneously tracking tyrosinase (TYR) and adenosine triphosphate (ATP). With the help of this probe, the intricate correlation and regulatory mechanism between TYR and ATP during oxidative stress is uncovered.
Hong Huang, Huiru Li, Yong Zhang, Xuhan Xia, Ningwen Zhang, Haixin Fan, Longhua Guo, Yongyong Cao, Hu Pan, Ruijie Deng, Yangang Wang, Rodrigo Ledesma‐Amaro, Jianguo Xu   +12 more
wiley   +1 more source