Results 121 to 130 of about 349,476 (296)

A ROS‐Responsive and Mucoadhesive Thermosensitive Hydrogel Encapsulated with Mizoribine for Synergistic Dry Eye Therapy

Advanced Science, EarlyView.
The ROS‐responsive in situ thermosensitive MZR@SPPP hydrogel system enables dual‐stage drug loading and sustained ocular delivery. Upon administration, it gelates at ocular surface temperature, enhancing ocular adhesion. By scavenging free radicals, restoring NRF2‐mediated antioxidant defense and mitochondrial homeostasis, and suppressing inflammatory ...
Danyi Qin, Jiani Li, Panqin Ma, Shinan Wu, Wenying Guan, Yimin Huang, Ke Feng, Mingyan Wei, Zixuan Yang, Shujia Guo, Caihong Huang, Yun‐Long Wu, Yi Han, Zuguo Liu   +13 more
wiley   +1 more source

3D Bioprinted Blood–Brain–Tumor Barrier Spheroid‐Based In Situ Evaluation of Anticancer Compounds Against Glioblastoma: ROS‐Producing Ruthenium as a Potential Therapeutic Candidate

Advanced Science, EarlyView.
The blood–brain–tumor barrier (BBTB) penetration by anticancer drugs and their effects on glioblastoma (GBM) is assessed using 3D bioprinted‐spheroids. Anticancer drug‐induced U‐87 MG cell death is quantified through in situ imaging of spheroids using a cancer cell death probe. The Ru compound, a partial P‐gp substrate, induces greater tumor‐cell death
Hyunjung Lee, Chan Ho Jeon, Doyun Kim, Minjae Lee, Minji Kwon, Joon Myong Song   +5 more
wiley   +1 more source

Ceruloplasmin and superoxide dismutase (SOD1) in heterozygotes for Wilson disease: A case control study.

, 2009
To access publisher full text version of this article. Please click on the hyperlink in Additional Links fieldAt the time of this study, there were five known patients with Wilson disease (WD) in Iceland.
Johannesson, Torkell, Kristinsson, Jakob, Torsdottir, Gudlaug, Gudmundsson, Gretar, Snaedal, Jon   +4 more
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Porphyrin‐Based Porous Materials for Antibacterial Applications

Advanced Science, EarlyView.
Porphyrin‐based porous materials have excellent photophysical properties and tunable structures for high‐efficiency antibacterial therapy. This review comprehensively discusses the structural design strategies and synthetic pathways of the four main types of porphyrin‐based porous materials, summarizes their cross‐domain antimicrobial applications, and
Xiao‐Xue Liang, Xin Li, Ying Xiong, Xin Wang, Ying‐Wei Yang   +4 more
wiley   +1 more source

Dissecting the Molecular Mechanisms of Motor Neurone Disease in Yeast and Worms [PDF]

Superoxide dismutase 1 (SOD1) is an enzyme responsible for intracellular breakdown of toxic reactive oxygen species in prokaryotes and eukaryotes. Mutations in SOD1 are linked to the motor neurone disease Amyotrophic lateral sclerosis (ALS), with around ...
Peswani, Amber Rose
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Superoxide and superoxide dismutase in red blood cells [PDF]

, 1976
In 1969 a previously obscure copper protein of red blood cells, erythrocuprein, was shown to catalyse the dismutation of superoxide radicals. Erythrocuprein thus became superoxide dismutase and the object of intensive study.
Bannister, William H., Anastasi, Angela, Bannister, J. V.   +2 more
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Vitamin B₁₂ and Redox Homeostasis: Cob(II)alamin Reacts with Superoxide at Rates Approaching Superoxide Dismutase (SOD)

, 2016
Vitamin B12 and Redox Homeostasis: Cob(II)alamin Reacts with Superoxide at Rates Approaching Superoxide Dismutase ...
Nicola E. Brasch (1851817), Edward Suarez-Moreira (2341804), Andrew McCaddon (2341810), June Yun (2341807), John H. H. Williams (2341798), Catherine S. Birch (2341801)   +5 more
core   +1 more source

Mn/Zn Bimetallic MOF‐Integrated Hydrogel Alleviates Excessive Mitochondrial Fission in BMSCs to Promote Osteoporotic Jawbone Repair

Advanced Science, EarlyView.
Excessive reactive oxygen species (ROS) and chronic inflammation impair bone marrow‐derived mesenchymal stem cells (BMSCs), contributing to poor healing in osteoporotic jawbone defect. The gelatin methacryloyl hydrogel loaded with manganese‐doped zeolitic imidazolate framework (Mn‐ZIF‐8@GelMA) promotes regeneration through redox regulation and ...
Xiayue Jin, Shengjia Ye, Yun Yuan, Xueying Yang, Jiarui Cui, Hongming Zhang, Hui Huang   +6 more
wiley   +1 more source

Superoxide Dismutase Enzyme (SOD)

, 2008
Bu ders notunda süperoksid dismutaz (SOD) enziminin üç boyutlu yapısı, koenzim ve kofaktörleri ile bazı özellikleri anlatılmaktadır.This lecture note is about the enzyme superoxide dismutase, its 3D structure, coenzymes and cofactors and some other ...
ERKOC, FIGEN
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Characterization of inhibitors for Cu/Zn superoxide dismutase observed by ¹?F NMR methods [PDF]

, 2010
Superoxide dismutase (SOD) is an enzyme that disproportionates superoxide (O2-) into H2O2 and O2. The inhibition of this enzyme could be a novel method for the treatment of chronic diseases such as leukemia, cancer and malaria.2,7,8 Methods that rely on ...
NC DOCKS at Western Carolina University, Markley, Jonathan   +1 more
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