Results 141 to 150 of about 349,476 (296)
Advanced Science, EarlyView.Cross‐organ multi‐omics reveals coordinated inflammatory and metabolic disturbances in 5xFAD mice. Huanglian Jiedu Decoction improves cognition and alleviates brain and liver abnormalities. Complementary hepatocyte–microglia conditioned‐medium experiments suggest PPAR‐γ involvement in treatment‐associated changes in microglial inflammation, providing ...
Wenya Gao +10 more
wiley +1 more source
Advanced Science, EarlyView.An integrated phenomics–genomics framework captures dynamic salt‐stress responses in laboratory‐grown cotton seedlings through time‐series hyperspectral imaging and non‐destructive i‐trait extraction. Hierarchical screening identifies biologically relevant, heritable, and non‐redundant traits for high‐resolution GWAS, identifying GhST7.
Bowei Xu +11 more
wiley +1 more source
Advanced Science, EarlyView.Circulating polyethylene microplastic burden is positively associated with heightened ADHD symptom severity and systemic redox‐inflammatory imbalance in children. Mechanistic investigation in a developmental co‐exposure mouse model further demonstrates that microplastics aggravate ADHD‐like behaviors, dopaminergic dysregulation, and oxidative ...
Yufan Luo +12 more
wiley +1 more source
International Journal of Nanomedicine, 2012 Yoon Jung Choi,1,* Jue Yeon Lee,2,* Chong Pyoung Chung,2 Yoon Jeong Park,1,21Craniomaxillofacial Reconstructive Sciences, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea; 2Research Institute, Nano ...
Park YJ, Chung CP, Lee JY, Choi YJ
doaj
Blood SOD1 Activity in ALS Patients Receiving Tofersen Treatment
Annals of Neurology, EarlyView.Objective The antisense oligonucleotide tofersen is the first disease‐modifying drug for SOD1‐related amyotrophic lateral sclerosis (ALS) and was approved because of its ability to reduce SOD1 protein and neurofilament levels. The effect of tofersen on SOD1 activity is unclear but of clinical relevance because homozygous SOD1 mutations, linked to ...
Katharina Goehring +18 more
wiley +1 more source
Patient‐Derived Fibroblasts as a Clinically Relevant Model of Kearns–Sayre Syndrome
Annals of Neurology, EarlyView.Objective Kearns–Sayre syndrome (KSS) is characterized by single large‐scale mitochondrial DNA deletions and by severe early‐onset clinical manifestations with neurological involvement. Reliable disease models, as well as validated biomarkers or effective treatments, are lacking.
Laura Valls‐Roca +24 more
wiley +1 more source
A Comprehensive Toxicological Safety Assessment of Superoxide Dismutase as a Novel Food Ingredient. [PDF]
J ToxicolChen D +11 more
europepmc +1 more source
Photochemical Oxygen‐Atom‐Transfer Reactivity of Platinum(II) Peroxycarbonates
Angewandte Chemie, EarlyView.The coordination chemistry of metal–peroxycarbonate complexes (M(CO4)) remains poorly understood, with no reported studies of the photochemical reactivity of M(CO4) complexes. The platinum(II) peroxycarbonate complexes Pt(PPh3)2(CO4) and Pt(dppe)(CO4) (dppe = 1,2‐bis(diphenylphosphino)ethane) have been structurally characterized and are shown to ...
Meghan G. Sullivan +4 more
wiley +1 more source