Results 111 to 120 of about 10,484 (294)
Advanced Science, EarlyView.We developed a pH responsive theranostic serum albumin hydrogel named BST, functionalized with MRI and CT probes and loaded with mitochondria targeted CAT‐SOD nanogels, that rapidly self repairs and mechanically stabilizes the infarcted myocardium, releases therapeutic nanogels and albumin under hypoxia induced acidosis to clear mitochondrial ROS ...
Zheng Luo +7 more
wiley +1 more source
ROS‐Targeted Nanomotor Therapy in OA: Cartilage Protection and Pain Relief
Advanced Science, EarlyView.ROS‐responsive NM@MET nanomotors utilize elevated ROS in osteoarthritic joints to promote deep penetration into cartilage and synovium and enable sustained metformin release. By scavenging ROS, regulating NRF2/KEAP1 signaling, protecting chondrocytes, suppressing synovial inflammation, and attenuating nociceptive signaling, NM@MET alleviates pain and ...
Meng Zheng +19 more
wiley +1 more source
Davao Research JournalThe occurrence of ineffective antibiotics and an abundance of waste shell has provided a research opportunity to study calcium compounds through natural recycling, derived from the abundant gleaned species of gastropod conch (Canarium urceus) shells ...
Kate Loucille C. Ibañez +1 more
doaj +1 more source
Advanced Science, EarlyView.Safe and precise bioorthogonal therapy of tumors was achieved by an ultrasound‐responsive heterostructured nanoreactor with on‐demand catalytic activity. Under piezoelectric catalysis, the system undergoes reversible Pd2+/Pd0 redox cycling, concurrently enabling spatiotemporally controlled prodrug activation and self‐terminating catalytic dose ...
Daqing Xia +9 more
wiley +1 more source
The synthesis of higher oxides of alkali and alkaline earth metals in an electric discharge: Theoretical and experimental studies [PDF]
, 1974 Potassium hydroxide was subjected to the products of an electrical discharge sustained in oxygen and produced both potassium peroxide and superoxide. The conversion to higher oxides was shown to strongly depend upon the particle size of KOH, the position
Bell, A. T., Sadhukhan, P.
core
Investigation of Pyrrolidinium-based Superoxides and Ozonides [PDF]
Pyrrolidinium-based cations were systematically modified to investigate their influence on ozonide and superoxide anions and to understand the scattering of experimentally determined dimensions of these radical anions.
Rennefeld, Oliver R. H. +9 more
core +1 more source
Advanced Science, EarlyView.Chronic microinflammation in high myopia suppresses MANF in lens epithelial cells. MANF normally resides within MAMs and promotes ubiquitin‐mediated degradation of the ER Ca2+ pump SERCA2. MANF loss causes pathological SERCA2 accumulation, MAM hyperassembly, and disrupted ER‐to‐mitochondria Ca2+ transfer, leading to mitochondrial failure, oxidative ...
Xin Liu +8 more
wiley +1 more source
The Role of Trace Elements In Rheumatoid Arthritis
مجله دانشکده پزشکی اصفهان, 2014 Background: Rheumatoid arthritis (RA) is an autoimmune disease with unknown origin. Several etiologic factors have been attributed to the pathogenesis of RA, which is substantially derived by inflammatory factor.
Sepideh Hejazi +2 more
doaj
Advanced Science, EarlyView.CR8L10 is self‐assembled with catalase (CAT) to form CR8L10@CAT nanocomplexes, which can anchor to mucosal surfaces via thiol‐disulfide exchange with mucin, thereby enhancing their mucosal retention. The efficient reactive oxygen species (ROS) scavenging at inflamed sites would then result in successful treatment in both the intravesical IC/BPS model ...
Xinzhu Li +13 more
wiley +1 more source
Advanced Science, EarlyView.This study uncovers a previously unrecognized copper‐COMMD1‐SOD1 regulatory axis, revealing that pathological copper overload paradoxically suppresses SOD1 activity by promoting COMMD1‐dependent disruption of SOD1 homodimerization. These findings redefine the regulatory role of copper in SOD1 biology and provide novel mechanistic insight into the ...
Yuqing Liu +7 more
wiley +1 more source