Results 311 to 320 of about 50,050 (338)

Microplate Superoxide Dismutase Assay Employing a Nonenzymatic Superoxide Generator

Analytical Biochemistry, 1995
The antioxidant enzyme superoxide dismutase (EC 1.15.1.1) (SOD) catalyzes the conversion of superoxide anion radical (O2.-) to hydrogen peroxide and molecular oxygen. SOD helps prevent tissue damage by O2.- and its metabolites, and augmentation of tissue SOD is a useful therapeutic strategy in certain diseases having an oxidative-injury component ...
J F, Ewing, D R, Janero
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Electrostatic recognition between superoxide and copper, zinc superoxide dismutase

Nature, 1983
Electrostatic forces have been implicated in a variety of biologically important molecular interactions including drug orientation by DNA, protein folding and assembly, substrate binding and catalysis and macromolecular complementarity with inhibitors, drugs and hormones.
E D, Getzoff, J A, Tainer, P K, Weiner, P A, Kollman, J S, Richardson, D C, Richardson   +5 more
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Superoxide Radical and Superoxide Dismutases: Threat and Defense

1980
An enzymic flux of O2- and H2O2 caused strand breaks in the supercoiled covalently closed circular Col El plasmid. Subnanomolar levels of superoxide levels of superoxide dismutase or of catalase prevented this attack on DNA, signifying that both O2- and H2O2 were required.
K, Brawn, I, Fridovich
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Superoxide-Superoxide Oxidoreductase Activity of the Captopril-Copper Complex

Archives of Medical Research, 2002
The purpose of this study was to determine whether the interaction of captopril, an angiotensin-converting enzyme inhibitor, with copper could modify the superoxide dismutase activity of this metal. Results may help to explain the interaction of captopril with reactive oxygen species in the stunned myocardium where substantial mobilization of copper ...
David, Jay, Elizabeth J, García, María del Carmen, Avila, Eduardo, Muñoz, Roberto, Gleason   +4 more
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Superoxide interaction with nickel and iron superoxide dismutases

Journal of Molecular Graphics and Modelling, 2009
Interaction of superoxide with the metal active sites of nickel and iron-containing superoxide dismutases is investigated with density functional theory. Outer-sphere mechanisms for both the reduction and oxidation of superoxide are proposed to be the common feature of these structurally unrelated SODs.
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Superoxide Dismutase-Based Third-Generation Biosensor for Superoxide Anion

Analytical Chemistry, 2002
A third-generation biosensor for superoxide anion (O2-) was developed by immobilizing superoxide dismutase (SOD) on a self-assembled monolayer of cysteine on gold electrode; i.e., a SOD/cysteine-modified gold electrode (SOD/Cys/Au) was fabricated. A rapid and direct electron transfer of SOD was realized at the gold electrode by using the cysteine ...
Y.Tian, L.Mao, T.Okajima, T.Ohsaka
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Superoxide-Mediated Cytotoxicity in Superoxide Dismutase-Deficient Fetal Fibroblasts

Archives of Biochemistry and Biophysics, 1997
To investigate the roles of CuZn superoxide dismutase (CuZnSOD) and Mn superoxide dismutase (MnSOD) in oxygen radical-mediated cytotoxicity and to distinguish the actions of these two enzymes, fetal fibroblasts were derived from mouse fetuses that are either deficient in CuZnSOD (Sod1-/+ and -/-) or MnSOD (Sod2-1+ and -/-) for in vitro studies. Whereas
T T, Huang, M, Yasunami, E J, Carlson, A M, Gillespie, A G, Reaume, E K, Hoffman, P H, Chan, R W, Scott, C J, Epstein   +8 more
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Microbial Superoxide Dismutases

1989
Publisher Summary The presence of oxygen in the environment presents both advantages and threat to all forms of life. The use of oxygen as a final electron acceptor provides more energy than that afforded by anaerobic fermentation. Oxygen is also useful in many biosynthetic reactions.
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Superoxide constitutes a major signal of mitochondrial superoxide flash

Life Sciences, 2013
Mitochondrial flashes detected with an N- and C-terminal circularly-permuted yellow fluorescent protein (cpYFP) have been thought to represent transient and quantal bursts of superoxide production under physiological, stressful and pathophysiological conditions.
Xing, Zhang, Zhanglong, Huang, Tingting, Hou, Jiejia, Xu, Yanru, Wang, Wei, Shang, Tao, Ye, Heping, Cheng, Feng, Gao, Xianhua, Wang   +9 more
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SUPEROXIDE RADICALS, SUPEROXIDE DISMUTASES AND THE AEROBIC LIFESTYLE

Photochemistry and Photobiology, 1978
Abstract— The superoxide radical (O‐2) is a commonplace product of the biological reduction of molecular oxygen and plays an important role in oxygen toxicity. Superoxide dismutases (SOD) catalytically scavenge this radical and are the primary defense against its cytotoxicity. The data which support these statements have been briefly reviewed.
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