The SOD1 Inhibitor, LCS-1, Oxidizes H2S to Reactive Sulfur Species, Directly and Indirectly, through Conversion of SOD1 to an Oxidase. [PDF]
Olson KR +11 more
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Aggregability of the SQSTM1/p62-based aggresome-like induced structures determines the sensitivity to parthanatos. [PDF]
Hamano S +13 more
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Supersulfide catabolism participates in maladaptive remodeling of cardiac cells
The atrophic myocardium resulting from mechanical unloading and nutritional deprivation is considered crucial as maladaptive remodeling directly associated with heart failure, as well as interstitial fibrosis. Conversely, myocardial hypertrophy resulting from hemodynamic loading is perceived as compensatory stress adaptation. We previously reported the
Motohiro Nishida +2 more
exaly +3 more sources
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Supersulfide-Mediated Signaling during Differentiation and De-Differentiation
2021Tsuyoshi Takata +4 more
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Regulation of innate immune and inflammatory responses by supersulfides
International ImmunologyAbstractInnate immunity plays an important role in host defense against microbial infections. It also participates in activation of acquired immunity through cytokine production and antigen presentation. Pattern recognition receptors such as Toll-like receptors and nucleotide oligomerization domain-like receptors sense invading pathogens and associated
Hiroyasu Tsutsuki +3 more
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Dynamic transformation of the sulfur metabolome during natto fermentation: Supersulfide omics study
Nitric Oxide - Biology and ChemistrySupersulfides are sulfur species with catenated sulfur atoms, such as cysteine hydropersulfide (CysSSH). Although supersulfides are biologically important metabolites owing to their unique chemical properties, their transformation in plants via microbial fermentation remains unknown. Natto is a traditional Japanese food prepared from soybeans fermented
Tomoaki Ida +2 more
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Redox Regulation of Xenobiotics by Reactive Sulfur and Supersulfide Species
Antioxidants and Redox SignalingSignificance: Routine exposure to xenobiotics is unavoidable during our lifetimes. Certain xenobiotics are hazardous to human health, and are metabolized in the body to render them less toxic. During this process, several detoxification enzymes cooperatively metabolize xenobiotics.
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Supersulfides are a class of sulfur compounds in either zero-valent or monovalent negative states, such as elemental sulfur, inorganic polysulfides, and organic polysulfides, and they play crucial roles in biological systems, environmental sulfur cycling, and Li-S batteries. However, accurate quantification of these compounds remains challenging due to
Huaiwei Liu, Xianzhe Gong, Ning Du
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Quantitative profiling of supersulfides naturally occurring in dietary meats and beans
Analytical BiochemistrySulfur is essential in the inception of life and crucial for maintaining human health. This mineral is primarily supplied through the intake of proteins and is used for synthesizing various sulfur-containing biomolecules. Recent research has highlighted the biological significance of endogenous supersulfides, which include reactive persulfide species ...
Shingo Kasamatsu +10 more
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Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates
Journal of Oral BiosciencesWhile chondrocytes have mitochondria, they receive little O2 from the bloodstream. Sulfur respiration, an essential energy production system in mitochondria, uses supersulfides instead of O2. Supersulfides are inorganic and organic sulfides with catenated sulfur atoms and are primarily produced by cysteinyl tRNA synthetase-2 (CARS2).
Yuji, Sasama +8 more
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