Supersulfide formation in the sinus mucosa of chronic rhinosinusitis [PDF]
Laryngoscope Investigative OtolaryngologyObjectives Disruption of the oxidative stress defense system is involved in developing various diseases. Sulfur compounds such as glutathione (GSH) and cysteine (CysSH) are representative antioxidants in the body.
Jun Suzuki +14 more
doaj +3 more sources
Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides [PDF]
Redox BiologySupersulfides, sulfur species containing catenated sulfur atoms, are potent reducing agents produced by diverse organisms. Although their intracellular functions are increasingly recognized, the ecological and physiological importance of gut microbial ...
Jun Uchiyama
exaly +4 more sources
Hepatic supersulfides attenuate acetaminophen-induced liver injury via enhanced detoxification and anti-inflammatory mechanisms [PDF]
Redox BiologyAcetaminophen (APAP) is a widely used antipyretic and analgesic agent; however, overdose can lead to hepatotoxicity and, in severe cases, acute liver failure.
Yukio Fujiwara
exaly +6 more sources
Supersulfides contribute to joint homeostasis and bone regeneration [PDF]
Redox BiologyThe physiological functions of supersulfides, inorganic and organic sulfides with sulfur catenation, have been extensively studied. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal ...
Takaaki Akaike, Masanobu Morita
exaly +4 more sources
The Therapeutic Potential of Supersulfides in Oxidative Stress-Related Diseases [PDF]
BiomoleculesOxidation-reduction (redox) reactions are fundamental to sustaining life, with reactive oxygen and nitrogen species playing pivotal roles in cellular signaling and homeostasis. However, excessive oxidative stress disrupts redox balance, contributing to a
Takaaki Akaike +2 more
exaly +4 more sources
Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases [PDF]
Microbiology and ImmunologyABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Tomohiro Sawa +2 more
exaly +3 more sources
Role of Sulfide Quinone Oxidoreductase and Supersulfides in Hepatic Ischemia–Reperfusion Injury in Mice [PDF]
AntioxidantsHepatic ischemia–reperfusion injury (IRI) is a critical clinical condition associated with liver transplantation and acute liver injury. This study investigated the role of sulfide quinone oxidoreductase (SQOR) and its downstream product, supersulfides ...
Takahito Kawano, Masaharu Murata
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Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides [PDF]
Redox BiologyIschemic heart disease is the main global cause of death in the world. Abnormal sulfide catabolism, especially hydrogen sulfide accumulation, impedes mitochondrial respiration and worsens the prognosis after ischemic insults, but the substantial ...
Motohiro Nishida
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Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality [PDF]
Redox BiologySupersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related ...
Takaaki Akaike, Masanobu Morita
exaly +4 more sources
Oxygen needs sulfur, sulfur needs oxygen: a relationship of interdependence [PDF]
EMBO JournalOxygen and sulfur, both members of the chalcogen group (group 16 elements), play fundamental roles in life. Ancient organisms primarily utilized sulfur for energy metabolism, while the rise in atmospheric oxygen facilitated the evolution of aerobic ...
Takaaki Akaike +2 more
exaly +3 more sources