Results 21 to 30 of about 145 (85)

Unique response of polysulfide in serum albumin to oxidative stress [PDF]

Scientific Reports
Supersulfide species have been identified as molecules that have catenated sulfur atoms as persulfides (R-SSH) and polysulfides (R-SSnH). The physiological activities of intracellular supersulfides have been widely studied, but little is known about the ...
Mayumi Ikeda-Imafuku, Maki Sakai, Keitaro Umezawa, Hidehiko Nakagawa, Toru Maruyama, Masaki Otagiri, Takaaki Akaike, Tomohiro Sawa, Ming Xian, Yuri Miura, Tatsuhiro Ishida, Yu Ishima   +11 more
doaj   +2 more sources

Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice [PDF]

Nature Communications
The presence of redox-active molecules containing catenated sulfur atoms (supersulfides) in living organisms has led to a review of the concepts of redox biology and its translational strategy.
Akiyuki Nishimura, Seiryo Ogata, Xiaokang Tang, Kowit Hengphasatporn, Keitaro Umezawa, Makoto Sanbo, Masumi Hirabayashi, Yuri Kato, Yuko Ibuki, Yoshito Kumagai, Kenta Kobayashi, Yasunari Kanda, Yasuteru Urano, Yasuteru Shigeta, Takaaki Akaike, Motohiro Nishida   +15 more
doaj   +2 more sources

Abstracts of the 84^th Annual Meeting of the Japanese Cancer Association. [PDF]

Cancer Sci
Cancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
europepmc   +2 more sources

Supersulfide catalysis for nitric oxide and aldehyde metabolism. [PDF]

Sci Adv, 2023
Abundant formation of endogenous supersulfides, which include reactive persulfide species and sulfur catenated residues in thiols and proteins (supersulfidation), has been observed. We found here that supersulfides catalyze S -nitrosoglutathione (GSNO) metabolism via glutathione-dependent electron transfer from ...
Kasamatsu S, Nishimura A, Alam MM, Morita M, Shimoda K, Matsunaga T, Jung M, Ogata S, Barayeu U, Ida T, Nishida M, Nishimura A, Motohashi H, Akaike T.   +13 more
europepmc   +3 more sources

Editorial: Exploring sulfur compounds’ role in inflammation and therapeutic potential [PDF]

Frontiers in Immunology
Małgorzata Iciek, Tomohiro Sawa, Eugenia Rita Lauriano, Magdalena Kotańska   +3 more
doaj   +2 more sources

Silver Tip (<i>Camellia sinensis</i>) Extract Promotes Supersulfide Biosynthesis in Keratinocytes. [PDF]

Int J Mol Sci
“Supersulfides” is a general term for compounds containing multiple sulfur atoms within their molecules. Owing to their potent anti-oxidant and anti-inflammatory activities, these species are promising ingredients in the field of cosmetics. In this study, we elucidated the effect of silver tip (Camellia sinensis) tea on supersulfide production in ...
Kunihiro K, Sano K, Suzuki S.
europepmc   +2 more sources

Colon-Targeting Supersulfide Donor-Drug Conjugates Align Forces against Inflammation. [PDF]

JACS Au
Supersulfides are rising stars in regulating redox. Their distinctive redox biological functions are becoming increasingly evident with the advancement of supersulfide donors. However, most existing donors are limited to releasing hydropersulfide (RSSH) only, and in addition, there is still a knowledge gap in translating supersulfides into therapeutic ...
Zhang Y, Cao GY, Zhou Z, Hu TY, Xu BX, Chen DA, Du JB, Wang J, Wang G, Zhen L.   +9 more
europepmc   +4 more sources

The Role of Supersulfide in Methylmercury Detoxification

YAKUGAKU ZASSHI
Methylmercury is a ubiquitous neurotoxic substance present in the environment, and health concerns, especially through the consumption of seafood, remain. Glutathione (GSH)-mediated detoxification and the excretion of methylmercury are known metabolic detoxification pathways.
Takashi, Toyama, Runa, Kudo, Yoshiro, Saito   +2 more
openaire   +2 more sources

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Reactive oxygen species: Multidimensional regulators of plant adaptation to abiotic stress and development

Journal of Integrative Plant Biology, Volume 66, Issue 3, Page 330-367, March 2024.
This review provides an overview of recent advancements in reactive oxygen species detection methods, metabolism, signaling, and the significance of reactive oxygen species in plant growth, development, and adaptation to abiotic stress. ABSTRACT Reactive oxygen species (ROS) are produced as undesirable by‐products of metabolism in various cellular ...
Pengtao Wang, Wen‐Cheng Liu, Chao Han, Situ Wang, Ming‐Yi Bai, Chun‐Peng Song   +5 more
wiley   +1 more source