Supersulfide biology and translational medicine for disease control
British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026., 2023 Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu +5 more
wiley +4 more sources
Albumin as a dynamic extracellular redox regulator: from Cys34 oxidation biomarkers to polysulfide-mediated homeostatic mechanisms and clinical applications [PDF]
Redox ReportHuman serum albumin (HSA) is the most abundant circulating protein and a central mediator of extracellular redox homeostasis. Its antioxidant function has been attributed primarily to the free thiol at cysteine residue 34 (Cys34), whose progressive ...
Yu Ishima +6 more
doaj +2 more sources
Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways [PDF]
PharmaceuticalsOxidative stress is responsible for the onset and progression of various kinds of diseases including rhabdomyolysis-induced acute kidney injury (AKI).
Mayumi Ikeda-Imafuku +7 more
doaj +2 more sources
Longevity control by supersulfides [PDF]
Longevity control by supersulfidesTohoku University博士（医学 ...
YOON, SUNGHYEON
core +3 more sources
Colon-Targeting Supersulfide Donor-Drug Conjugates Align Forces against Inflammation. [PDF]
JACS AuSupersulfides are rising stars in regulating redox. Their distinctive redox biological functions are becoming increasingly evident with the advancement of supersulfide donors.
Zhang Y +9 more
europepmc +5 more sources
Abstracts of the 84<sup>th</sup> Annual Meeting of the Japanese Cancer Association. [PDF]
Cancer SciCancer Science, Volume 117, Issue S1, Page 1-2148, January 2026.
europepmc +2 more sources
Neuronal nitric oxide synthase is regulated by supersulfides
Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022 Yukihiro Tsuchiya +2 more
semanticscholar +2 more sources
[Characterization of Supersulfide in Serum Albumin and Its Therapeutic Application].
YAKUGAKU ZASSHIRecent studies have shown that proteins already possess supersulfides during the translation. However, the distribution and the role of supersulfides are not fully understood.
Mayumi Ikeda +6 more
semanticscholar +3 more sources
Editorial: Exploring sulfur compounds’ role in inflammation and therapeutic potential [PDF]
Frontiers in ImmunologyMałgorzata Iciek +3 more
doaj +2 more sources
[Supersulfides in Environmental Toxicology and Hygiene].
YAKUGAKU ZASSHIKazuhiro Nishiyama, Takashi Toyama
semanticscholar +3 more sources