Results 11 to 20 of about 145 (85)

Supersulfide donors and their therapeutic targets in inflammatory diseases [PDF]

Frontiers in Immunology
Inflammation is one defense mechanism of the body that has multiple origins, ranging from physical agents to infectious agents including viruses and bacteria.
Tianli Zhang, Yuexuan Pan, Tomohiro Sawa, Takaaki Akaike, Takaaki Akaike, Tetsuro Matsunaga, Tetsuro Matsunaga   +6 more
doaj   +4 more sources

How super is supersulfide?: Reconsidering persulfide reactivity in cellular biology [PDF]

Redox Biology, 2023
In an attempt to understand the cellular mechanisms of H2S signalling, recent research has focused on supersulfide (i.e., alkyl and inorganic hydropersulfide) formation and subsequent reactivity.
Christopher H. Switzer
doaj   +4 more sources

Supersulfides regulate cell migration in human skin keratinocytes

Cell Structure and Function
As the outermost organ, the skin is particularly susceptible to physical damage. Keratinocytes are a major component of the epidermis, and their migration plays a crucial role in skin wound healing.
Kento Kunihiro, Katsura Sano
doaj   +5 more sources

Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer. [PDF]

Cancer Sci
This study evaluated the potential of sulfur metabolites as biomarkers for esophageal cancer using blood and exhaled breath condensate (EBC) samples. Absolute quantification analysis revealed elevated levels of cysteine hydropersulfide (CysSSH) and homocysteine hydropersulfide (HomoCysSSH) in patients with esophageal cancer, with HomoCysSSH in plasma ...
Asamitsu S, Ozawa Y, Okamoto H, Ogata S, Matsunaga T, Yoshitake J, Fusegawa K, Taniyama Y, Sato C, Ishida H, Abe T, Motohashi H, Akaike T, Kamei T.   +13 more
europepmc   +4 more sources

Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides

Advances in Redox Research, 2023
Keratin is a central component of human hair proteins, which explicitly possesses many cysteine residues (Cys-SH). For a long time, these Cys-SH residues were believed to contribute to human hair strength by forming intra- and inter-molecular disulfide ...
Tatsuhiro Ishida, Yu Ishima, Ming Xian   +2 more
exaly   +4 more sources

Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop [PDF]

Redox Biology, 2023
The excessive inflammatory response of macrophages plays a vital role in the pathogenesis of various diseases. The dynamic metabolic alterations in macrophages, including amino acid metabolism, are known to orchestrate their inflammatory phenotype.
Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi   +10 more
doaj   +2 more sources

Albumin as a dynamic extracellular redox regulator: from Cys34 oxidation biomarkers to polysulfide-mediated homeostatic mechanisms and clinical applications [PDF]

Redox Report
Human serum albumin (HSA) is the most abundant circulating protein and a central mediator of extracellular redox homeostasis. Its antioxidant function has been attributed primarily to the free thiol at cysteine residue 34 (Cys34), whose progressive ...
Yu Ishima, Hiroshi Watanabe, Mayumi Ikeda-Imafuku, Hitoshi Maeda, Toru Maruyama, Masaki Otagiri, Victor T. G. Chuang   +6 more
doaj   +2 more sources

Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways [PDF]

Pharmaceuticals
Oxidative stress is responsible for the onset and progression of various kinds of diseases including rhabdomyolysis-induced acute kidney injury (AKI).
Mayumi Ikeda-Imafuku, Tatsuya Fukuta, Victor Tuan Giam Chuang, Tomohiro Sawa, Toru Maruyama, Masaki Otagiri, Tatsuhiro Ishida, Yu Ishima   +7 more
doaj   +2 more sources

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026., 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida, Fan‐Yan Wei, Hozumi Motohashi, Takaaki Akaike   +5 more
wiley   +3 more sources

The Supersulfide-Producing Activity of Rat Cystathionine γ-Lyase Is Irreversibly Inactivated by L-CysNO but Not by L-GSNO [PDF]

Antioxidants
Cystathionine γ-lyase (CSE) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the final step of the transsulfuration pathway, converting cystathionine into cysteine.
Shoma Araki, Tsuyoshi Takata, Sunghyeon Yoon, Shingo Kasamatsu, Hideshi Ihara, Hidehiko Nakagawa, Takaaki Akaike, Yukihiro Tsuchiya, Yasuo Watanabe   +8 more
doaj   +2 more sources