How super is supersulfide?: Reconsidering persulfide reactivity in cellular biology [PDF]
Redox Biology, 2023 In an attempt to understand the cellular mechanisms of H2S signalling, recent research has focused on supersulfide (i.e., alkyl and inorganic hydropersulfide) formation and subsequent reactivity.
Christopher H. Switzer
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Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides
Advances in Redox Research, 2023 Keratin is a central component of human hair proteins, which explicitly possesses many cysteine residues (Cys-SH). For a long time, these Cys-SH residues were believed to contribute to human hair strength by forming intra- and inter-molecular disulfide ...
Ming Xian +2 more
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The Supersulfide-Producing Activity of Rat Cystathionine γ-Lyase Is Irreversibly Inactivated by L-CysNO but Not by L-GSNO [PDF]
AntioxidantsCystathionine γ-lyase (CSE) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the final step of the transsulfuration pathway, converting cystathionine into cysteine.
Shoma Araki +8 more
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Supersulfide donors and their therapeutic targets in inflammatory diseases [PDF]
Frontiers in ImmunologyInflammation is one defense mechanism of the body that has multiple origins, ranging from physical agents to infectious agents including viruses and bacteria.
Tianli Zhang +6 more
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Supersulfides regulate cell migration in human skin keratinocytes
Cell Structure and FunctionAs the outermost organ, the skin is particularly susceptible to physical damage. Keratinocytes are a major component of the epidermis, and their migration plays a crucial role in skin wound healing.
Kento Kunihiro, Katsura Sano
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Oxygen needs sulfur, sulfur needs oxygen: a relationship of interdependence [PDF]
EMBO JournalOxygen and sulfur, both members of the chalcogen group (group 16 elements), play fundamental roles in life. Ancient organisms primarily utilized sulfur for energy metabolism, while the rise in atmospheric oxygen facilitated the evolution of aerobic ...
Hiroki Sekine +2 more
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Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop [PDF]
Redox Biology, 2023 The excessive inflammatory response of macrophages plays a vital role in the pathogenesis of various diseases. The dynamic metabolic alterations in macrophages, including amino acid metabolism, are known to orchestrate their inflammatory phenotype.
Haruna Takeda +10 more
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Supersulfide catalysis for nitric oxide and aldehyde metabolism [PDF]
Science Advances, 2023 Abundant formation of endogenous supersulfides, which include reactive persulfide species and sulfur catenated residues in thiols and proteins (supersulfidation), has been observed.
Masanobu Morita
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Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer. [PDF]
Cancer SciThis study evaluated the potential of sulfur metabolites as biomarkers for esophageal cancer using blood and exhaled breath condensate (EBC) samples. Absolute quantification analysis revealed elevated levels of cysteine hydropersulfide (CysSSH) and homocysteine hydropersulfide (HomoCysSSH) in patients with esophageal cancer, with HomoCysSSH in plasma ...
Asamitsu S +13 more
europepmc +4 more sources
Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice [PDF]
Nature CommunicationsThe presence of redox-active molecules containing catenated sulfur atoms (supersulfides) in living organisms has led to a review of the concepts of redox biology and its translational strategy.
Akiyuki Nishimura +15 more
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