Results 31 to 40 of about 234 (94)

Cystathionine γ-lyase self-inactivates by generating supersulfides

Proceedings for Annual Meeting of The Japanese Pharmacological Society, 2022
Shoma Araki, Yukihiro Tsuchiya, Y. Watanabe   +2 more
semanticscholar   +2 more sources

Sulfide:quinone oxidoreductase drives mitochondrial supersulfide metabolism to regulate bioenergetics and longevity in eukaryotes

bioRxiv
Sulfide:quinone oxidoreductase (SQR) is a critical enzyme that maintains sulfur metabolism by oxidizing sulfide to supersulfides, currently defined as sulfur metabolites with six valence electrons and no charge that are covalently catenated with other ...
Jia Yao, Tetsuro Matsunaga, Akira Nishimura, M. Shieh, T. Ida, Minkyung Jung, Seiryo Ogata, Tsuyoshi Takata, U. Barayeu, Hozumi Motohashi, Masanobu Morita, Takaaki Akaike   +11 more
semanticscholar   +2 more sources

Therapeutic Efficacy of the Supersulfide Donor NAC-S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses. [PDF]

Microbiol Immunol
Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic ...
Hossen F, Kouwaki T, Fujiwara Y, Tsutsuki H, Zhang T, Guo C, Rahman A, Komohara Y, Oshiumi H, Sawa T.   +9 more
europepmc   +2 more sources

Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides [PDF]

, 2023
Keratin is a central component of human hair proteins, which explicitly possesses many cysteine residues (Cys-SH). For a long time, these Cys-SH residues were believed to contribute to human hair strength by forming intra-and inter-molecular disulfide ...
ヒライ, タケル, タサカ, ナナミ, イシマ, ユウ, Tasaka, Nanami, アカイケ, タカアキ, 60644/profile-ja.html, Xian, Ming, 石田, 竜弘, Ishima, Yu, Chuang, Victor Tuan Giam, Ishida, Tatsuhiro, イケダ イマフク, マユミ, イシダ, タツヒロ, 310655/profile-ja.html, 1145, 50325271, Hirai, Takeru, Akaike, Takaaki, 異島, 優, Ikeda-Imafuku, Mayumi, 828   +20 more
core  

Silver Tip (<i>Camellia sinensis</i>) Extract Promotes Supersulfide Biosynthesis in Keratinocytes. [PDF]

Int J Mol Sci
“Supersulfides” is a general term for compounds containing multiple sulfur atoms within their molecules. Owing to their potent anti-oxidant and anti-inflammatory activities, these species are promising ingredients in the field of cosmetics. In this study,
Kunihiro K, Sano K, Suzuki S.
europepmc   +2 more sources

Serendipitous Discovery of Photolytic Thiosulfoxide Formation: Application for Visible-Light-Inducible Manipulation of Supersulfide Level in Biological Systems. [PDF]

J Am Chem Soc
Tools to enable spatiotemporally controlled upregulation of supersulfides, which are highly reactive, unstable sulfur species, are needed to study the pathophysiological roles of post-translational protein modification with catenated sulfur atoms.
Kawaguchi M, Yoshino K, Ida T, Moriyama H, Ieda N, Ohta Y, Kasamatsu S, Ihara H, Nakagawa H.   +8 more
europepmc   +2 more sources

The Role of Supersulfide in Methylmercury Detoxification

YAKUGAKU ZASSHI
Methylmercury is a ubiquitous neurotoxic substance present in the environment, and health concerns, especially through the consumption of seafood, remain. Glutathione (GSH)-mediated detoxification and the excretion of methylmercury are known metabolic detoxification pathways.
Takashi, Toyama, Runa, Kudo, Yoshiro, Saito   +2 more
openaire   +2 more sources

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Reactive oxygen species: Multidimensional regulators of plant adaptation to abiotic stress and development

Journal of Integrative Plant Biology, Volume 66, Issue 3, Page 330-367, March 2024.
This review provides an overview of recent advancements in reactive oxygen species detection methods, metabolism, signaling, and the significance of reactive oxygen species in plant growth, development, and adaptation to abiotic stress. ABSTRACT Reactive oxygen species (ROS) are produced as undesirable by‐products of metabolism in various cellular ...
Pengtao Wang, Wen‐Cheng Liu, Chao Han, Situ Wang, Ming‐Yi Bai, Chun‐Peng Song   +5 more
wiley   +1 more source

Supersulfide catabolism participates in maladaptive remodeling of cardiac cells

Journal of Pharmacological Sciences
The atrophic myocardium resulting from mechanical unloading and nutritional deprivation is considered crucial as maladaptive remodeling directly associated with heart failure, as well as interstitial fibrosis. Conversely, myocardial hypertrophy resulting from hemodynamic loading is perceived as compensatory stress adaptation. We previously reported the
Liuchenzi Zhou, Akiyuki Nishimura, Keitaro Umezawa, Yuri Kato, Xinya Mi, Tomoya Ito, Yasuteru Urano, Takaaki Akaike, Motohiro Nishida   +8 more
openaire   +2 more sources