Results 1 to 10 of about 2,461 (127)

Synthetic Motifs for Understanding Lewis Acid Interactions with Persulfides and Thioselenides. [PDF]

Angew Chem Int Ed Engl
Using isolated dichalcogenides as precursors, we report the synthesis, characterization, and reactivity of Zn persulfide and thioselenide complexes. 77Se NMR shows distinct impacts to electronic structure and reactivity between different thioselenides coordinated to different Lewis acids.
Li K, Sattler AJ, Zakharov LN, Pluth MD.
europepmc   +3 more sources

Redox Signaling Regulated by Cysteine Persulfide and Protein Polysulfidation

Molecules, 2016
For decades, reactive persulfide species including cysteine persulfide (CysSSH) have been known to exist endogenously in organisms. However, the physiological significance of endogenous persulfides remains poorly understood. That cystathionine β-synthase
Shigemoto Fujii, Hisyam Abdul Hamid, Akira Nishimura   +2 more
exaly   +3 more sources

Enzymes that generate and regulate intracellular persulfides and polysulfides: mechanistic insights and inhibitors [PDF]

Frontiers in Physiology
Reactive sulfur species (RSS), which include various persulfides and polysulfides, are generated by multiple enzymes in vivo and play critical roles in mammalian physiological processes such as redox signaling, metabolic regulation, radical scavenging ...
Ko Hirabayashi, Eita Sasaki, Hisashi Ohno, Orie Takayama, Sota Yamada, Kenjiro Hanaoka, Kenjiro Hanaoka   +6 more
doaj   +2 more sources

Toxic Tear Gas 2-Chloroacetophenone (CN) Forms Adducts With Endogenous Plasma Thiols In Vitro Valuable as Biomarkers of Exposure. [PDF]

Drug Test Anal
Incubation of human plasma with the tear gas 2‐chloroacetophenone (CN) led to the formation of acetophenone (AcPhen)‐adducts with the small plasma thiols glutathione, homocysteine, and cysteine persulfide. The AcPhen‐adducts were either bound to an organic thiol‐group or to an organic persulfide. The adducts were detected with a mass spectrometry‐based
Sieber PH, Steinritz D, Worek F, John H.
europepmc   +2 more sources

Therapeutic Efficacy of the Supersulfide Donor NAC-S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses. [PDF]

Microbiol Immunol
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Hossen F, Kouwaki T, Fujiwara Y, Tsutsuki H, Zhang T, Guo C, Rahman A, Komohara Y, Oshiumi H, Sawa T.   +9 more
europepmc   +2 more sources

Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein [PDF]

eLife
Cysteine-bound sulfane sulfur atoms in proteins have received much attention as key factors in cellular redox homeostasis. However, the role of sulfane sulfur in zinc regulation has been underinvestigated.
Yasuhiro Shinkai, Yunjie Ding, Toru Matsui, George Devitt, Masahiro Akiyama, Tang-Long Shen, Motohiro Nishida, Tomoaki Ida, Takaaki Akaike, Sumeet Mahajan, Jon M Fukuto, Yasuteru Shigeta, Yoshito Kumagai   +12 more
doaj   +2 more sources

Zero-valent sulfur is the product of assimilatory sulfite reductase and a substrate of cysteine synthase [PDF]

Applied and Environmental Microbiology
The process of the assimilatory sulfate reduction consists of sulfate reduction to hydrogen sulfide (H2S) and then H2S assimilation for cysteine synthesis.
Qun Cao, Xuanyu Liu, Qingda Wang, Yongzhen Xia, Luying Xun, Huaiwei Liu   +5 more
doaj   +2 more sources

The Role of Persulfide Metabolism During Arabidopsis Seed Development Under Light and Dark Conditions

Frontiers in Plant Science, 2018
The sulfur dioxygenase ETHE1 oxidizes persulfides in the mitochondrial matrix and is involved in the degradation of L-cysteine and hydrogen sulfide. ETHE1 has an essential but as yet undefined function in early embryo development of Arabidopsis thaliana.
Takayuki Tohge, Ljudmilla Borisjuk, Nicolas Heinzel   +2 more
exaly   +3 more sources

Persulfide Dioxygenase From Acidithiobacillus caldus: Variable Roles of Cysteine Residues and Hydrogen Bond Networks of the Active Site

Frontiers in Microbiology, 2018
Persulfide dioxygenases (PDOs) are abundant in Bacteria and also crucial for H2S detoxification in mitochondria. One of the two pdo-genes of the acidophilic bacterium Acidithiobacillus caldus was expressed in Escherichia coli.
Arnulf Kletzin, Patrick Ruhl
exaly   +3 more sources

2-Thiouridine formation in Escherichia coli: a critical review [PDF]

Journal of Bacteriology
Modifications of transfer RNA (tRNA) have been shown to play critical roles in the biogenesis, metabolism, structural stability, and function of RNA molecules, and the specific modifications of nucleobases with sulfur atoms in tRNA are present in ...
Silke Leimkühler
doaj   +2 more sources