Results 21 to 30 of about 2,511 (170)
Angewandte Chemie, 2022 AbstractProtein persulfides (R‐S‐SH) have emerged as a common post‐translational modification. Detection and quantitation of protein persulfides requires trapping with alkylating agents. Here we show that alkylating agents differ dramatically in their ability to conserve the persulfide's sulfur–sulfur bond for subsequent detection by mass spectrometry.
Danny Schilling +5 more
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Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides
Biomolecules, 2020 Cysteine persulfide (CysSSH) and cysteine polysulfides (CysSSnH, n > 1) are cysteine derivatives that have sulfane sulfur atoms bound to cysteine thiol. Advances in analytical methods that detect and quantify persulfides and polysulfides have shown that ...
Tomohiro Sawa +3 more
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Reactions of isolated persulfides provide insights into the interplay between H2S and persulfide reactivity [PDF]
Free Radical Biology and Medicine, 2015 Hydrogen sulfide is ubiquitous in biological systems and exerts function over a wide range of important physiological processes. Complementing free H2S, the reductant-labile sulfur pool plays significant roles in the translocation and action of sulfide, however the chemistry of reductant-labile sulfide sources has not been studied systematically. Using
T Spencer, Bailey, Michael D, Pluth
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Antioxidants, 2023 Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide and glutathione persulfide, are endogenously produced in abundance in both prokaryotes and eukaryotes, including mammals.
Qamarul Hafiz Zainol Abidin +13 more
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mBio, 2020 Acinetobacter baumannii is an opportunistic nosocomial pathogen that is the causative agent of several serious infections in humans, including pneumonia, sepsis, and wound and burn infections. A.
Brenna J. C. Walsh +7 more
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Microorganisms, 2022 Bacterial phage-like particles (gene transfer agents—GTAs) are widely employed as a crucial genetic vector in horizontal gene transfer. GTA-mediated gene transfer is induced in response to various stresses; however, regulatory mechanisms are poorly ...
Takayuki Shimizu +3 more
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Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species
Antioxidants, 2019 Hydrogen sulfide (H2S/HS⁻) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH).
Dayana Benchoam +3 more
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Metabolic and Structural Insights into Hydrogen Sulfide Mis-Regulation in Enterococcus faecalis
Antioxidants, 2022 Hydrogen sulfide (H2S) is implicated as a cytoprotective agent that bacteria employ in response to host-induced stressors, such as oxidative stress and antibiotics.
Brenna J. C. Walsh +6 more
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Direct Proteomic Mapping of Cysteine Persulfidation [PDF]
Antioxidants & Redox Signaling, 2020 Aims: Cysteine persulfidation (also called sulfhydration or sulfuration) has emerged as a potential redox mechanism to regulate protein functions and diverse biological processes in hydrogen sulfide (H2S) signaling. Due to its intrinsically unstable nature, working with this modification has proven to be challenging.
Ling, Fu +5 more
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Mechanism of Iron–Sulfur Cluster Assembly: In the Intimacy of Iron and Sulfur Encounter
Inorganics, 2020 Iron–sulfur (Fe–S) clusters are protein cofactors of a multitude of enzymes performing essential biological functions. Specialized multi-protein machineries present in all types of organisms support their biosynthesis.
Batoul Srour +3 more
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