Results 11 to 20 of about 3,419 (230)

Synthesis, Characterization, and Reactivity of a Synthetic End-on Cobalt (II) Alkyl Persulfide Complex as a Model Platform for Thiolate Persulfidation [PDF]

Journal of the American Chemical Society
Persulfides (RSS–) are ubiquitous source of sulfides (S2–) in biology, and interactions between RSS– and bioinorganic metal centers play critical roles in biological hydrogen sulfide (H2S) biogenesis, signaling, and catabolism.
Keyan, Li, Lev, Zakharov, Michael, Pluth
core   +4 more sources

Persulfide Dioxygenase From Acidithiobacillus caldus: Variable Roles of Cysteine Residues and Hydrogen Bond Networks of the Active Site

Frontiers in Microbiology, 2018
Persulfide dioxygenases (PDOs) are abundant in Bacteria and also crucial for H2S detoxification in mitochondria. One of the two pdo-genes of the acidophilic bacterium Acidithiobacillus caldus was expressed in Escherichia coli.
Patrick Ruhl, Jan Becker, Arnulf Kletzin   +2 more
exaly   +4 more sources

Reactions of isolated persulfides provide insights into the interplay between H2S and persulfide reactivity [PDF]

Free Radical Biology and Medicine, 2015
Hydrogen sulfide is ubiquitous in biological systems and exerts function over a wide range of important physiological processes. Complementing free H2S, the reductant-labile sulfur pool plays significant roles in the translocation and action of sulfide, however the chemistry of reductant-labile sulfide sources has not been studied systematically. Using
T Spencer, Bailey, Michael D, Pluth
openaire   +4 more sources

Enzymatic Regulation and Biological Functions of Reactive Cysteine Persulfides and Polysulfides [PDF]

Biomolecules, 2020
Cysteine persulfide (CysSSH) and cysteine polysulfides (CysSSnH, n > 1) are cysteine derivatives that have sulfane sulfur atoms bound to cysteine thiol. Advances in analytical methods that detect and quantify persulfides and polysulfides have shown that ...
Tomohiro Sawa, Hozumi Motohashi, Hideshi Ihara, Takaaki Akaike   +3 more
doaj   +2 more sources

Persulfidation of DJ-1: Mechanism and Consequences

Biomolecules, 2022
DJ-1 (also called PARK7) is a ubiquitously expressed protein involved in the etiology of Parkinson disease and cancers. At least one of its three cysteine residues is functionally essential, and its oxidation state determines the specific function of the
Erwan Galardon, Nicolas Mathas, Dominique Padovani, Laurent Le Corre, Gabrielle Poncet, Julien Dairou   +5 more
doaj   +3 more sources

Esterase-Activated Perthiocarbonate Persulfide Donors Provide Insights into Persulfide Persistence and Stability

ACS Chemical Biology, 2022
Persulfides (RSSH) are important reactive sulfur species (RSS) that are intertwined with the biological functions of hydrogen sulfide (H2S). The direct study of persulfides is difficult, however, due to their both nucleophilic and electrophilic character,
Emma J. Mullen, Hannah C. Pigg, Matthew M. Cerda (1363320), Matthew M. Cerda, Michael D. Pluth, Kaylin G. Fosnacht (11945331), Emma J. Mullen (11945334), Hannah C. Pigg (11945337), Michael D. Pluth (138037), Kaylin G. Fosnacht   +9 more
core   +3 more sources

Persulfide-Responsive Transcription Factor SqrR Regulates Gene Transfer and Biofilm Formation via the Metabolic Modulation of Cyclic di-GMP in Rhodobacter capsulatus [PDF]

Microorganisms, 2022
Bacterial phage-like particles (gene transfer agents—GTAs) are widely employed as a crucial genetic vector in horizontal gene transfer. GTA-mediated gene transfer is induced in response to various stresses; however, regulatory mechanisms are poorly ...
Takayuki Shimizu, Toma Aritoshi, J. Thomas Beatty, Tatsuru Masuda   +3 more
doaj   +2 more sources

Possible molecular basis of the biochemical effects of cysteine-derived persulfides [PDF]

Frontiers in Molecular Biosciences, 2022
Persulfides (RSSH/RSS−) are species closely related to thiols (RSH/RS−) and hydrogen sulfide (H2S/HS−), and can be formed in biological systems in both low and high molecular weight cysteine-containing compounds.
Ernesto Cuevasanta, Ernesto Cuevasanta, Ernesto Cuevasanta, Dayana Benchoam, Dayana Benchoam, Dayana Benchoam, Jonathan A. Semelak, Matías N. Möller, Matías N. Möller, Ari Zeida, Ari Zeida, Madia Trujillo, Madia Trujillo, Beatriz Alvarez, Beatriz Alvarez, Darío A. Estrin   +15 more
doaj   +2 more sources

Self-S-sulfonation in a bacterial persulfide dioxygenase mediates thiol persulfide detoxification [PDF]

A ubiquitous class of non-heme Fe(II) enzymes, the persulfide dioxygenases (PDOs), provide protection against hydrogen sulfide (H2S) poisoning. The PDO in humans is a single-domain enzyme, while bacterial PDOs, such as CstB of Staphylococcus aureus, are often fused to a sulfurtransferase (rhodanese) module.
Julius O. Campecino, Sofia S. Costa, Brenna J.C. Walsh, Jonathan C. Trinidad, Jyoti Kannoujia, Andrew T. Poor, Casey M. Van Stappen, Giovanni Gonzalez-Gutierrez, Margarida Archer, Jose A. Brito, David P. Giedroc   +10 more
openaire   +2 more sources

Formation of persulfide groups in alkaline treated insulin [PDF]

FEBS Letters, 1970
Alkaline treatment of disulfidecontaining proteins is known to produce a number of unusual compounds related with the degradation of the cystinyl residues. Lanthionine [l] and lysinoalanine [2] are among the products identified with certainly, while dehydroala- nine [2] , thiocysteine [3,4] , cysteine sulfenic acid [S] and other products are supposed ...
Cavallini, D., Federici, G., Barboni, E., Marcucci, M.   +3 more
openaire   +4 more sources