Results 31 to 40 of about 2,511 (170)

Oral Administration of Glutathione Trisulfide Increases Reactive Sulfur Levels in Dorsal Root Ganglion and Ameliorates Paclitaxel-Induced Peripheral Neuropathy in Mice

Antioxidants, 2022
Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically characterized by a predominantly sensory neuropathy presenting with allodynia, hyperalgesia and spontaneous
Mariko Ezaka, Eizo Marutani, Yusuke Miyazaki, Eiki Kanemaru, Martin K. Selig, Sophie L. Boerboom, Katrina F. Ostrom, Anat Stemmer-Rachamimov, Donald B. Bloch, Gary J. Brenner, Etsuo Ohshima, Fumito Ichinose   +11 more
doaj   +1 more source

Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals

Molecules, 2016
It was in the 1950s that the term polysulfide or persulfide was introduced in biological studies. The unfamiliar term “sulfane sulfur” sometimes appeared in papers published in the 1970s, and was defined in the review article by Westley in 1983.
Shin Koike, Yuki Ogasawara
doaj   +1 more source

Hypoxia increases persulfide and polysulfide formation by AMP kinase dependent cystathionine gamma lyase phosphorylation

Redox Biology, 2023
Hydropersulfide and hydropolysulfide metabolites are increasingly important reactive sulfur species (RSS) regulating numerous cellular redox dependent functions.
Shafiul Alam, Sibile Pardue, Xinggui Shen, John D. Glawe, Takashi Yagi, Mohammad Alfrad Nobel Bhuiyan, Rakesh P. Patel, Paari S. Dominic, Chiranjiv S. Virk, Md Shenuarin Bhuiyan, A. Wayne Orr, Chad Petit, Gopi K. Kolluru, Christopher G. Kevil   +13 more
doaj   +1 more source

Emerging Chemical Biology of Protein Persulfidation

Antioxidants & Redox Signaling, 2023
Significance: Protein persulfidation (the formation of RSSH), an evolutionarily conserved oxidative posttranslational modification in which thiol groups in cysteine residues are converted into persulfides, has emerged as one of the main mechanisms through which hydrogen sulfide (H
Vignane, Thibaut, Filipovic, Milos R.
openaire   +2 more sources

Pseudomonas aeruginosa PA1006 is a persulfide-modified protein that is critical for molybdenum homeostasis. [PDF]

PLoS ONE, 2013
A companion manuscript revealed that deletion of the Pseudomonas aeruginosa (Pae) PA1006 gene caused pleiotropic defects in metabolism including a loss of all nitrate reductase activities, biofilm maturation, and virulence.
Gregory Tombline, Johanna M Schwingel, John D Lapek, Alan E Friedman, Thomas Darrah, Michael Maguire, Nadine E Van Alst, Melanie J Filiatrault, Barbara H Iglewski   +8 more
doaj   +1 more source

The Rhodanese PspE Converts Thiosulfate to Cellular Sulfane Sulfur in Escherichia coli

Antioxidants, 2023
Hydrogen sulfide (H2S) and its oxidation product zero-valent sulfur (S0) play important roles in animals, plants, and bacteria. Inside cells, S0 exists in various forms, including polysulfide and persulfide, which are collectively referred to as sulfane ...
Qiaoli Yu, Mingxue Ran, Yuping Xin, Huaiwei Liu, Honglei Liu, Yongzhen Xia, Luying Xun   +6 more
doaj   +1 more source

The Role of Protein Persulfidation in Brain Aging and Neurodegeneration [PDF]

Frontiers in Aging Neuroscience, 2021
Hydrogen sulfide (H2S), originally considered a toxic gas, is now a recognized gasotransmitter. Numerous studies have revealed the role of H2S as a redox signaling molecule that controls important physiological/pathophysiological functions. The underlying mechanism postulated to serve as an explanation of these effects is protein persulfidation (P-SSH,
Petrovic, Dunja, Kouroussis, Emilia, Vignane, Thibaut, Filipovic, Milos R.   +3 more
openaire   +3 more sources

Persulfidation is the mechanism underlying sulfide-signaling of autophagy [PDF]

Autophagy, 2021
In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved
Gotor, Cecilia, Aroca, Angeles, Romero, Luis C.   +2 more
openaire   +5 more sources

Biosynthesis and Reactivity of Cysteine Persulfides in Signaling [PDF]

Journal of the American Chemical Society, 2015
Hydrogen sulfide (H2S) elicits pleiotropic physiological effects ranging from modulation of cardiovascular to CNS functions. A dominant method for transmission of sulfide-based signals is via posttranslational modification of reactive cysteine thiols to persulfides. However, the source of the persulfide donor and whether its relationship to H2S is as a
Pramod K, Yadav, Michael, Martinov, Victor, Vitvitsky, Javier, Seravalli, Rudolf, Wedmann, Milos R, Filipovic, Ruma, Banerjee   +6 more
openaire   +2 more sources

The ABCB7-Like Transporter PexA in Rhodobacter capsulatus Is Involved in the Translocation of Reactive Sulfur Species

Frontiers in Microbiology, 2019
The mitochondrial ATP-binding cassette (ABC) transporters ABCB7 in humans, Atm1 in yeast and ATM3 in plants, are highly conserved in their overall architecture and particularly in their glutathione binding pocket located within the transmembrane spanning
Simona Riedel, Beata Siemiatkowska, Mutsumi Watanabe, Christina S. Müller, Volker Schünemann, Rainer Hoefgen, Silke Leimkühler   +6 more
doaj   +1 more source