Results 51 to 60 of about 3,419 (230)
Mechanism of Iron–Sulfur Cluster Assembly: In the Intimacy of Iron and Sulfur Encounter
Inorganics, 2020 Iron–sulfur (Fe–S) clusters are protein cofactors of a multitude of enzymes performing essential biological functions. Specialized multi-protein machineries present in all types of organisms support their biosynthesis.
Batoul Srour +3 more
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Antioxidants, 2022 Peripheral neuropathy is a dose-limiting side effect of chemotherapy with paclitaxel. Paclitaxel-induced peripheral neuropathy (PIPN) is typically characterized by a predominantly sensory neuropathy presenting with allodynia, hyperalgesia and spontaneous
Mariko Ezaka +11 more
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Emerging Chemical Biology of Protein Persulfidation
Antioxidants & Redox Signaling, 2023 Significance: Protein persulfidation (the formation of RSSH), an evolutionarily conserved oxidative posttranslational modification in which thiol groups in cysteine residues are converted into persulfides, has emerged as one of the main mechanisms through which hydrogen sulfide (H
Vignane, Thibaut, Filipovic, Milos R.
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, 2023 Reactive sulfur species (RSS) and reactive selenium species (RSeS) play integral roles in hydrogen sulfide (H2S) and hydrogen selenide (H2Se) biological signaling pathways, and dichalcogenide anions are proposed transient intermediates that facilitate a ...
Keyan, Li, Lev, Zakharov, Michael, Pluth
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Sulfur Atom in its Bound State Is a Unique Element Involved in Physiological Functions in Mammals
Molecules, 2016 It was in the 1950s that the term polysulfide or persulfide was introduced in biological studies. The unfamiliar term “sulfane sulfur” sometimes appeared in papers published in the 1970s, and was defined in the review article by Westley in 1983.
Shin Koike, Yuki Ogasawara
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Structure and function of persulfide dioxygenase from <i>Pseudomonas aeruginosa</i>: Implications on H<sub>2</sub>S homeostasis and interplay with nitric oxide. [PDF]
iScienceGiordano F +11 more
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The Role of Protein Persulfidation in Brain Aging and Neurodegeneration [PDF]
Frontiers in Aging Neuroscience, 2021 Hydrogen sulfide (H2S), originally considered a toxic gas, is now a recognized gasotransmitter. Numerous studies have revealed the role of H2S as a redox signaling molecule that controls important physiological/pathophysiological functions. The underlying mechanism postulated to serve as an explanation of these effects is protein persulfidation (P-SSH,
Petrovic, Dunja +3 more
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Persulfidation is the mechanism underlying sulfide-signaling of autophagy [PDF]
Autophagy, 2021 In this commentary, we highlight the findings described in a recent paper regarding the mechanism of H2S regulation of macroautophagy/autophagy in mammalian cells and discuss the similarities/divergencies with plant cells. The main outcome is that the posttranslational modification of thiol groups of cysteine residues to form persulfides is a conserved
Gotor, Cecilia +2 more
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The Rhodanese PspE Converts Thiosulfate to Cellular Sulfane Sulfur in Escherichia coli
Antioxidants, 2023 Hydrogen sulfide (H2S) and its oxidation product zero-valent sulfur (S0) play important roles in animals, plants, and bacteria. Inside cells, S0 exists in various forms, including polysulfide and persulfide, which are collectively referred to as sulfane ...
Qiaoli Yu +6 more
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Biosynthesis and Reactivity of Cysteine Persulfides in Signaling [PDF]
Journal of the American Chemical Society, 2015 Hydrogen sulfide (H2S) elicits pleiotropic physiological effects ranging from modulation of cardiovascular to CNS functions. A dominant method for transmission of sulfide-based signals is via posttranslational modification of reactive cysteine thiols to persulfides. However, the source of the persulfide donor and whether its relationship to H2S is as a
Pramod K, Yadav +6 more
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