How super is supersulfide?: Reconsidering persulfide reactivity in cellular biology [PDF]
Redox Biology, 2023 In an attempt to understand the cellular mechanisms of H2S signalling, recent research has focused on supersulfide (i.e., alkyl and inorganic hydropersulfide) formation and subsequent reactivity.
Christopher H Switzer
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Supersulfide formation in the sinus mucosa of chronic rhinosinusitis [PDF]
Laryngoscope Investigative OtolaryngologyObjectives Disruption of the oxidative stress defense system is involved in developing various diseases. Sulfur compounds such as glutathione (GSH) and cysteine (CysSH) are representative antioxidants in the body.
Jun Suzuki +14 more
doaj +6 more sources
The Supersulfide-Producing Activity of Rat Cystathionine γ-Lyase Is Irreversibly Inactivated by L-CysNO but Not by L-GSNO [PDF]
AntioxidantsCystathionine γ-lyase (CSE) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the final step of the transsulfuration pathway, converting cystathionine into cysteine.
Shoma Araki +2 more
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Acute Kidney Injury Caused by Rhabdomyolysis Is Ameliorated by Serum Albumin-Based Supersulfide Donors through Antioxidative Pathways [PDF]
PharmaceuticalsOxidative stress is responsible for the onset and progression of various kinds of diseases including rhabdomyolysis-induced acute kidney injury (AKI).
Mayumi Ikeda-Imafuku +2 more
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Supersulfide donors and their therapeutic targets in inflammatory diseases [PDF]
Frontiers in ImmunologyInflammation is one defense mechanism of the body that has multiple origins, ranging from physical agents to infectious agents including viruses and bacteria.
Tianli Zhang +2 more
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Supersulfide controls intestinal inflammation by suppressing CD4+ T cell proliferation [PDF]
Frontiers in ImmunologyInflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation where CD4+ T lymphocytes play an essential role. Accumulating evidence suggests that immune responses driven by CD4+ T cells are critically regulated by various ...
Shunichi Tayama +2 more
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Supersulfide metabolome of exhaled breath condensate applied as diagnostic biomarkers for esophageal cancer [PDF]
Cancer ScienceThis study evaluated the potential of sulfur metabolites as biomarkers for esophageal cancer using blood and exhaled breath condensate (EBC) samples. Absolute quantification analysis revealed elevated levels of cysteine hydropersulfide (CysSSH) and homocysteine hydropersulfide (HomoCysSSH) in patients with esophageal cancer, with HomoCysSSH in plasma ...
Yohei Ozawa, Jun Yoshitake
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Longevity control by supersulfide-mediated mitochondrial respiration and regulation of protein quality [PDF]
Redox BiologySupersulfides, which are defined as sulfur species with catenated sulfur atoms, are increasingly being investigated in biology. We recently identified pyridoxal phosphate (PLP)-dependent biosynthesis of cysteine persulfide (CysSSH) and related ...
Masanobu Morita +2 more
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Colon-Targeting Supersulfide Donor–Drug Conjugates Align Forces against Inflammation [PDF]
Jacs AuSupersulfides are rising stars in regulating redox. Their distinctive redox biological functions are becoming increasingly evident with the advancement of supersulfide donors. However, most existing donors are limited to releasing hydropersulfide (RSSH) only, and in addition, there is still a knowledge gap in translating supersulfides into therapeutic ...
Guangji Wang, Le Zhen
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Hepatic supersulfides attenuate acetaminophen-induced liver injury via enhanced detoxification and anti-inflammatory mechanisms [PDF]
Redox BiologyAcetaminophen (APAP) is a widely used antipyretic and analgesic agent; however, overdose can lead to hepatotoxicity and, in severe cases, acute liver failure.
Chunyu Guo +11 more
doaj +2 more sources