Supersulfide catabolism participates in maladaptive remodeling of cardiac cells
Journal of Pharmacological SciencesThe atrophic myocardium resulting from mechanical unloading and nutritional deprivation is considered crucial as maladaptive remodeling directly associated with heart failure, as well as interstitial fibrosis. Conversely, myocardial hypertrophy resulting
Tomoya Itô +2 more
exaly +4 more sources
Silver Tip (<i>Camellia sinensis</i>) Extract Promotes Supersulfide Biosynthesis in Keratinocytes. [PDF]
Int J Mol Sci“Supersulfides” is a general term for compounds containing multiple sulfur atoms within their molecules. Owing to their potent anti-oxidant and anti-inflammatory activities, these species are promising ingredients in the field of cosmetics. In this study,
Kunihiro K, Sano K, Suzuki S.
europepmc +3 more sources
The Role of Supersulfide in Methylmercury Detoxification
Yakugaku ZasshiMethylmercury is a ubiquitous neurotoxic substance present in the environment, and health concerns, especially through the consumption of seafood, remain.
Yoshiro Saito
exaly +4 more sources
Increased intracellular H2S levels enhance iron uptake in Escherichia coli [PDF]
mBioWe investigated the impact of intracellular hydrogen sulfide (H2S) hyperaccumulation on the transcriptome of Escherichia coli. The wild-type (WT) strain overexpressing mstA, encoding 3-mercaptopyruvate sulfur transferase, produced significantly higher ...
Shouta Nonoyama +6 more
doaj +3 more sources
Unique response of polysulfide in serum albumin to oxidative stress [PDF]
Scientific ReportsSupersulfide species have been identified as molecules that have catenated sulfur atoms as persulfides (R-SSH) and polysulfides (R-SSnH). The physiological activities of intracellular supersulfides have been widely studied, but little is known about the ...
Mayumi Ikeda-Imafuku +11 more
doaj +3 more sources
Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop [PDF]
Redox Biology, 2023 The excessive inflammatory response of macrophages plays a vital role in the pathogenesis of various diseases. The dynamic metabolic alterations in macrophages, including amino acid metabolism, are known to orchestrate their inflammatory phenotype.
Haruna Takeda +10 more
doaj +2 more sources
Sulfide-Responsive Transcription Control in Escherichia coli [PDF]
MicroorganismsTo elucidate the mechanism of large-scale transcriptional changes dependent on sulfide in Escherichia coli, a large-scale RNA-sequencing analysis was performed on wild-type and sulfide-responsive transcription factor YgaV deletion mutants grown under ...
Koichi Hori +2 more
doaj +2 more sources
Oxidants induce Escherichia coli MarR glutathionylation in the presence of glutathione [PDF]
Redox BiologyThe results of protein thiols reacting with oxidants may be different in the presence or absence of glutathione (GSH). Upon exposure to oxidants, such as Cu2+ and polysulfide, the multiple drug resistant regulator MarR dimer in Escherichia coli is ...
Tianqi Wang +4 more
doaj +2 more sources
The Selective 3-MST Inhibitor I3MT-3 Works as a Potent Caspase-1 Inhibitor. [PDF]
Int J Mol SciI3MT-3 (HMPSNE) has been identified as a selective inhibitor of the supersulfide-producing enzyme 3-MST. In this study, we found that I3MT-3 inhibits inflammatory responses, including the secretion of the pro-inflammatory cytokine interleukin-1β (IL-1β ...
Otani K +5 more
europepmc +2 more sources
Innate immune regulation targeting supersulfide metabolism
Free Radical Biology and MedicineTomohiro Sawa
exaly +3 more sources