Results 31 to 40 of about 244 (100)

PNPO-PLP axis senses prolonged hypoxia in macrophages by regulating lysosomal activity. [PDF]

Nat Metab
Oxygen is critical for all metazoan organisms on the earth and impacts various biological processes in physiological and pathological conditions. While oxygen-sensing systems inducing acute hypoxic responses, including the hypoxia-inducible factor ...
Sekine H, Takeda H, Takeda N, Kishino A, Anzawa H, Isagawa T, Ohta N, Murakami S, Iwaki H, Kato N, Kimura S, Liu Z, Kato K, Katsuoka F, Yamamoto M, Miura F, Ito T, Takahashi M, Izumi Y, Fujita H, Yamagata H, Bamba T, Akaike T, Suzuki N, Kinoshita K, Motohashi H.   +25 more
europepmc   +2 more sources

[Characterization of Supersulfide in Serum Albumin and Its Therapeutic Application].

YAKUGAKU ZASSHI
Recent studies have shown that proteins already possess supersulfides during the translation. However, the distribution and the role of supersulfides are not fully understood.
Mayumi Ikeda, Tatsuya Fukuta, Yasunori Iwao, Masaki Otagiri, T. Maruyama, Tatsuhiro Ishida, Yu Ishima   +6 more
semanticscholar   +3 more sources

Supersulfide metabolome of exhaled breath condensate for diagnostic biomarkers of esophageal cancer.

Journal of Clinical Oncology
e15027 Background: The early estimate and detection of esophageal cancer (EC) is essentially required for continuous esophagogastroduodenoscopy and histopathological diagnosis.
Seji Asamitsu, Y. Ozawa, Seiryo Ogata, H. Okamoto, Jun Yoshitake, Tetsuro Matsunaga, Y. Taniyama, C. Sato, H. Ishida, T. Abe, Takaaki Akaike, Takashi Kamei   +11 more
semanticscholar   +2 more sources

The Therapeutic Potential of Supersulfides in Oxidative Stress-Related Diseases. [PDF]

Biomolecules
Oxidation-reduction (redox) reactions are fundamental to sustaining life, with reactive oxygen and nitrogen species playing pivotal roles in cellular signaling and homeostasis. However, excessive oxidative stress disrupts redox balance, contributing to a wide range of diseases, including inflammatory and pulmonary disorders, neurodegeneration, and ...
Pan Y, Matsunaga T, Zhang T, Akaike T.
europepmc   +4 more sources

Supersulfide metabolism in cardiac stress resistance

Free Radical Biology and Medicine
Motohiro Nishida, Akiyuki Nishimura
semanticscholar   +2 more sources

Role of Sulfide Quinone Oxidoreductase and Supersulfides in Hepatic Ischemia-Reperfusion Injury in Mice. [PDF]

Antioxidants (Basel)
Hepatic ischemia–reperfusion injury (IRI) is a critical clinical condition associated with liver transplantation and acute liver injury. This study investigated the role of sulfide quinone oxidoreductase (SQOR) and its downstream product, supersulfides, in hepatic IRI.
Takamori S, Shirozu K, Marutani E, Takata T, Mizuta Y, Kawano T, Murata M, Ida T, Matsunaga T, Akaike T, Yamaura K, Akahoshi T.   +11 more
europepmc   +4 more sources

Supersulfides to Regulate Electrophilic Stress

YAKUGAKU ZASSHI
Environmental electrophiles modify thiol groups of proteins in organs, disrupting cellular functions carried out by the modified proteins and increasing the risk of various diseases. The transcription factor NF-E2-related factor 2 (Nrf2) plays a crucial role in detoxifying electrophiles by forming glutathione adducts and subsequently excreting them ...
Masahiro, Akiyama, Jun, Uchiyama, Yoshito, Kumagai, Yun-Gi, Kim   +3 more
openaire   +2 more sources

NRF2 signalling in cytoprotection and metabolism

British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.
The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami, Yusuke Kusano, Keito Okazaki, Takaaki Akaike, Hozumi Motohashi   +4 more
wiley   +1 more source

Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides

Advances in Redox Research, 2023
Keratin is a central component of human hair proteins, which explicitly possesses many cysteine residues (Cys-SH). For a long time, these Cys-SH residues were believed to contribute to human hair strength by forming intra- and inter-molecular disulfide bond crosslinks.
Takeru Hirai, Mayumi Ikeda-Imafuku, Nanami Tasaka, Victor Tuan Giam Chuang, Ming Xian, Tatsuhiro Ishida, Takaaki Akaike, Yu Ishima   +7 more
openaire   +2 more sources

Supersulfide prevents cigarette smoke extract-induced mitochondria hyperfission and cardiomyocyte early senescence by inhibiting Drp1-filamin complex formation.

Journal of Pharmacological Sciences
Smoking is one of the most serious risk factors for cardiovascular diseases. Although cigarette mainstream and sidestream smoke are significant contributors to increased cardiovascular mortality and morbidity, the underlying mechanism is still unclear ...
Akiyuki Nishimura, Liuchenzi Zhou, Yuri Kato, Xinya Mi, Tomoya Ito, Yuko Ibuki, Yasunari Kanda, M. Nishida   +7 more
semanticscholar   +1 more source