Results 31 to 40 of about 177 (92)
The Role of Supersulfide in Methylmercury Detoxification
YAKUGAKU ZASSHIMethylmercury is a ubiquitous neurotoxic substance present in the environment, and health concerns, especially through the consumption of seafood, remain. Glutathione (GSH)-mediated detoxification and the excretion of methylmercury are known metabolic detoxification pathways.
Takashi, Toyama +2 more
openaire +2 more sources
Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides
Advances in Redox Research, 2023 Keratin is a central component of human hair proteins, which explicitly possesses many cysteine residues (Cys-SH). For a long time, these Cys-SH residues were believed to contribute to human hair strength by forming intra- and inter-molecular disulfide bond crosslinks.
Takeru Hirai +7 more
openaire +2 more sources
Supersulfides to Regulate Electrophilic Stress
YAKUGAKU ZASSHIEnvironmental electrophiles modify thiol groups of proteins in organs, disrupting cellular functions carried out by the modified proteins and increasing the risk of various diseases. The transcription factor NF-E2-related factor 2 (Nrf2) plays a crucial role in detoxifying electrophiles by forming glutathione adducts and subsequently excreting them ...
Masahiro, Akiyama +3 more
openaire +2 more sources
NRF2 signalling in cytoprotection and metabolism
British Journal of Pharmacology, Volume 183, Issue 1, Page 101-114, January 2026.The KEAP1‐NRF2 system plays a central role in cytoprotection in defence mechanisms against oxidative stress. The KEAP1‐NRF2 system has been regarded as a sulfur‐utilizing cytoprotective mechanism, because KEAP1 serves as a biosensor for electrophiles by using its reactive thiols and NRF2 is a transcriptional factor regulating genes involved in sulfur ...
Shohei Murakami +4 more
wiley +1 more source
, 1990 The mutual interactions of iron and sulfur in a borosilicate melt were defined as a function of the iron content, sulfur concentration, melt temperature, and oxygen fugacity. Over the range of conditions for which ions of SO2-4 - Fe3+ - Fe2+ or S2- - Fe2+
Schreiber, Charlotte W. +4 more
core +1 more source
Journal of Integrative Plant Biology, Volume 66, Issue 3, Page 330-367, March 2024.This review provides an overview of recent advancements in reactive oxygen species detection methods, metabolism, signaling, and the significance of reactive oxygen species in plant growth, development, and adaptation to abiotic stress. ABSTRACT Reactive oxygen species (ROS) are produced as undesirable by‐products of metabolism in various cellular ...
Pengtao Wang +5 more
wiley +1 more source
Identification of cysteinyl-tRNA synthetase as the principal supersulfide synthase in vivo
, 2022 Tohoku University博士（医学）博士学位論文 (Thesis(doctor ...
QAMARUL, HAFIZ BIN ZAINOL ABIDIN
core
, 2014 The reaction of the tripodal tris-amido U(iii) complex [U(SiMe 2NPh)3-tacn] (tacn = 1,4,7-triazacyclononane), 1, with 0.0625 and 0.25 equiv. of elemental sulfur affords the sulfide-bridged U(iv) complex [U((SiMe2NPh)3-tacn)2(μ-S)], 2, and the terminal ...
Marcalo, Joaquim +9 more
core +1 more source
Characterization of Supersulfide in Serum Albumin and Its Therapeutic Application
YAKUGAKU ZASSHIRecent studies have shown that proteins already possess supersulfides during the translation. However, the distribution and the role of supersulfides are not fully understood. In this review, we focus on supersulfides in biological fluids, especially in serum.
Mayumi, Ikeda +6 more
openaire +2 more sources
New aspects of redox signaling mediated by supersulfides in health and disease
Free Radical Biology and MedicineOxygen molecules accept electrons from the respiratory chain in the mitochondria and are responsible for energy production in aerobic organisms. The reactive oxygen species formed via these oxygen reduction processes undergo complicated electron transfer reactions with other biological substances, which leads to alterations in their physiological ...
Takaaki Akaike +8 more
openaire +3 more sources