Results 11 to 20 of about 244 (100)

Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides [PDF]

Redox Biology
Supersulfides, sulfur species containing catenated sulfur atoms, are potent reducing agents produced by diverse organisms. Although their intracellular functions are increasingly recognized, the ecological and physiological importance of gut microbial ...
Jun Uchiyama, Yoshimi Shimizu, Takamitsu Unoki, Shingo Kasamatsu, Tomoaki Ida, Hideshi Ihara, Yun-Gi Kim, Koji Hase, Yuri Miura, Tomohiko Maehama, Maiko Kusano, Keitaro Umezawa, Masahiro Akiyama   +12 more
doaj   +6 more sources

Supersulfides contribute to joint homeostasis and bone regeneration [PDF]

Redox Biology
The physiological functions of supersulfides, inorganic and organic sulfides with sulfur catenation, have been extensively studied. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal ...
Miki Maemura, Masanobu Morita, Seiryo Ogata, Yoichi Miyamoto, Tomoaki Ida, Kazuhiro Shibusaka, Soichiro Negishi, Masahiro Hosonuma, Taku Saito, Jun Yoshitake, Tsuyoshi Takata, Tetsuro Matsunaga, Eikan Mishima, Uladzimir Barayeu, Takaaki Akaike, Fumiko Yano   +15 more
doaj   +8 more sources

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases. [PDF]

Microbiol Immunol
Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles
Zhang T, Toyomoto T, Sawa T, Akaike T, Matsunaga T.   +4 more
europepmc   +5 more sources

Supersulfides regulate cell migration in human skin keratinocytes

Cell Structure and Function
As the outermost organ, the skin is particularly susceptible to physical damage. Keratinocytes are a major component of the epidermis, and their migration plays a crucial role in skin wound healing.
Kento Kunihiro, Katsura Sano
doaj   +6 more sources

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, Volume 183, Issue 1, Page 115-130, January 2026., 2023
For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms ...
U. Barayeu, T. Sawa, Motohiro Nishida, Fan-Yan Wei, H. Motohashi, Takaaki Akaike   +5 more
semanticscholar   +4 more sources

The Supersulfide-Producing Activity of Rat Cystathionine γ-Lyase Is Irreversibly Inactivated by L-CysNO but Not by L-GSNO [PDF]

Antioxidants
Cystathionine γ-lyase (CSE) is a pyridoxal 5′-phosphate (PLP)-dependent enzyme that catalyzes the final step of the transsulfuration pathway, converting cystathionine into cysteine.
Shoma Araki, Tsuyoshi Takata, Sunghyeon Yoon, Shingo Kasamatsu, Hideshi Ihara, Hidehiko Nakagawa, Takaaki Akaike, Yukihiro Tsuchiya, Yasuo Watanabe   +8 more
doaj   +3 more sources

Therapeutic Efficacy of the Supersulfide Donor NAC‐S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses [PDF]

Microbiology and Immunology
Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic ...
Yukio Fujiwara, Hiroyasu Tsutsuki, Tomohiro Sawa   +2 more
exaly   +3 more sources

Serendipitous Discovery of Photolytic Thiosulfoxide Formation: Application for Visible-Light-Inducible Manipulation of Supersulfide Level in Biological Systems [PDF]

Journal of the American Chemical Society
Tools to enable spatiotemporally controlled upregulation of supersulfides, which are highly reactive, unstable sulfur species, are needed to study the pathophysiological roles of post-translational protein modification with catenated sulfur atoms.
Naoya Ieda, Hidehiko Nakagawa, Mitsuyasu Kawaguchi   +2 more
exaly   +3 more sources

Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice [PDF]

Nature Communications
The presence of redox-active molecules containing catenated sulfur atoms (supersulfides) in living organisms has led to a review of the concepts of redox biology and its translational strategy.
Akiyuki Nishimura, Seiryo Ogata, Xiaokang Tang, Kowit Hengphasatporn, Keitaro Umezawa, Makoto Sanbo, Masumi Hirabayashi, Yuri Kato, Yuko Ibuki, Yoshito Kumagai, Kenta Kobayashi, Yasunari Kanda, Yasuteru Urano, Yasuteru Shigeta, Takaaki Akaike, Motohiro Nishida   +15 more
doaj   +3 more sources

Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides [PDF]

Redox Biology
Ischemic heart disease is the main global cause of death in the world. Abnormal sulfide catabolism, especially hydrogen sulfide accumulation, impedes mitochondrial respiration and worsens the prognosis after ischemic insults, but the substantial ...
Akiyuki Nishimura, Tomohiro Tanaka, Kakeru Shimoda, Tomoaki Ida, Shota Sasaki, Keitaro Umezawa, Hiromi Imamura, Yasuteru Urano, Fumito Ichinose, Toshiro Kaneko, Takaaki Akaike, Motohiro Nishida   +11 more
doaj   +3 more sources