Results 11 to 20 of about 177 (92)

Formation of a reducing microenvironment and regulation of protein supersulfidation by gut microbial supersulfides [PDF]

Redox Biology
Supersulfides, sulfur species containing catenated sulfur atoms, are potent reducing agents produced by diverse organisms. Although their intracellular functions are increasingly recognized, the ecological and physiological importance of gut microbial ...
Jun Uchiyama, Yoshimi Shimizu, Takamitsu Unoki, Shingo Kasamatsu, Tomoaki Ida, Hideshi Ihara, Yun-Gi Kim, Koji Hase, Yuri Miura, Tomohiko Maehama, Maiko Kusano, Keitaro Umezawa, Masahiro Akiyama   +12 more
doaj   +4 more sources

Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides [PDF]

Redox Biology
Ischemic heart disease is the main global cause of death in the world. Abnormal sulfide catabolism, especially hydrogen sulfide accumulation, impedes mitochondrial respiration and worsens the prognosis after ischemic insults, but the substantial ...
Akiyuki Nishimura, Tomohiro Tanaka, Kakeru Shimoda, Tomoaki Ida, Shota Sasaki, Keitaro Umezawa, Hiromi Imamura, Yasuteru Urano, Fumito Ichinose, Toshiro Kaneko, Takaaki Akaike, Motohiro Nishida   +11 more
doaj   +3 more sources

Supersulfides contribute to joint homeostasis and bone regeneration [PDF]

Redox Biology
The physiological functions of supersulfides, inorganic and organic sulfides with sulfur catenation, have been extensively studied. Their synthesis is mainly mediated by mitochondrial cysteinyl-tRNA synthetase (CARS2) that functions as a principal ...
Miki Maemura, Masanobu Morita, Seiryo Ogata, Yoichi Miyamoto, Tomoaki Ida, Kazuhiro Shibusaka, Soichiro Negishi, Masahiro Hosonuma, Taku Saito, Jun Yoshitake, Tsuyoshi Takata, Tetsuro Matsunaga, Eikan Mishima, Uladzimir Barayeu, Takaaki Akaike, Fumiko Yano   +15 more
doaj   +7 more sources

Sulfur metabolic response in macrophage limits excessive inflammatory response by creating a negative feedback loop [PDF]

Redox Biology, 2023
The excessive inflammatory response of macrophages plays a vital role in the pathogenesis of various diseases. The dynamic metabolic alterations in macrophages, including amino acid metabolism, are known to orchestrate their inflammatory phenotype.
Haruna Takeda, Shohei Murakami, Zun Liu, Tomohiro Sawa, Masatomo Takahashi, Yoshihiro Izumi, Takeshi Bamba, Hideyo Sato, Takaaki Akaike, Hiroki Sekine, Hozumi Motohashi   +10 more
doaj   +3 more sources

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases. [PDF]

Microbiol Immunol
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Zhang T, Toyomoto T, Sawa T, Akaike T, Matsunaga T.   +4 more
europepmc   +4 more sources

Supersulfides regulate cell migration in human skin keratinocytes

Cell Structure and Function
As the outermost organ, the skin is particularly susceptible to physical damage. Keratinocytes are a major component of the epidermis, and their migration plays a crucial role in skin wound healing.
Kento Kunihiro, Katsura Sano
doaj   +5 more sources

Supersulfide biology and translational medicine for disease control

British Journal of Pharmacology, 2023
Abstract For decades, the major focus of redox biology has been oxygen, the most abundant element on Earth. Molecular oxygen functions as the final electron acceptor in the mitochondrial respiratory chain, contributing to energy production in aerobic organisms. In addition, oxygen‐derived reactive oxygen species including hydrogen peroxide and nitrogen
Uladzimir Barayeu, Tomohiro Sawa, Motohiro Nishida   +2 more
exaly   +4 more sources

Supersulfide catalysis for nitric oxide and aldehyde metabolism [PDF]

Science Advances, 2023
Abundant formation of endogenous supersulfides, which include reactive persulfide species and sulfur catenated residues in thiols and proteins (supersulfidation), has been observed. We found here that supersulfides catalyze S -nitrosoglutathione (GSNO) metabolism via glutathione-dependent electron transfer from ...
Masanobu Morita
exaly   +4 more sources

Sulfide-Responsive Transcription Control in Escherichia coli [PDF]

Microorganisms
To elucidate the mechanism of large-scale transcriptional changes dependent on sulfide in Escherichia coli, a large-scale RNA-sequencing analysis was performed on wild-type and sulfide-responsive transcription factor YgaV deletion mutants grown under ...
Koichi Hori, Rajalakshmi Balasubramanian, Shinji Masuda   +2 more
doaj   +2 more sources

Polysulfur-based bulking of dynamin-related protein 1 prevents ischemic sulfide catabolism and heart failure in mice [PDF]

Nature Communications
The presence of redox-active molecules containing catenated sulfur atoms (supersulfides) in living organisms has led to a review of the concepts of redox biology and its translational strategy.
Akiyuki Nishimura, Seiryo Ogata, Xiaokang Tang, Kowit Hengphasatporn, Keitaro Umezawa, Makoto Sanbo, Masumi Hirabayashi, Yuri Kato, Yuko Ibuki, Yoshito Kumagai, Kenta Kobayashi, Yasunari Kanda, Yasuteru Urano, Yasuteru Shigeta, Takaaki Akaike, Motohiro Nishida   +15 more
doaj   +2 more sources