Results 41 to 50 of about 3,419 (230)

Commonly Used Alkylating Agents Limit Persulfide Detection by Converting Protein Persulfides into Thioethers

Angewandte Chemie, 2022
AbstractProtein persulfides (R‐S‐SH) have emerged as a common post‐translational modification. Detection and quantitation of protein persulfides requires trapping with alkylating agents. Here we show that alkylating agents differ dramatically in their ability to conserve the persulfide's sulfur–sulfur bond for subsequent detection by mass spectrometry.
Danny Schilling, Uladzimir Barayeu, Raphael R. Steimbach, Deepti Talwar, Aubry K. Miller, Tobias P. Dick   +5 more
openaire   +2 more sources

Contribution of NRF2 to sulfur metabolism and mitochondrial activity

Redox Biology, 2023
NF-E2-related factor 2 (NRF2) plays a crucial role in the maintenance of cellular homeostasis by regulating various enzymes and proteins that are involved in the redox reactions utilizing sulfur.
Md Morshedul Alam, Akihiro Kishino, Eunkyu Sung, Hiroki Sekine, Takaaki Abe, Shohei Murakami, Takaaki Akaike, Hozumi Motohashi   +7 more
doaj   +1 more source

Recent Advances in the Elucidation of Frataxin Biochemical Function Open Novel Perspectives for the Treatment of Friedreich’s Ataxia

Frontiers in Neuroscience, 2022
Friedreich’s ataxia (FRDA) is the most prevalent autosomic recessive ataxia and is associated with a severe cardiac hypertrophy and less frequently diabetes.
Beata Monfort, Kristian Want, Sylvain Gervason, Benoit D’Autréaux   +3 more
doaj   +1 more source

Simultaneous and sensitive quantification of protein and low molecular weight persulfides, polysulfides and H₂S in biological samples. [PDF]

Nat Commun
Miljkovic JL, Burger N, Yu CS, Harkiss AH, Warrington S, Caldwell ST, Jones SA, Lee JJ, Aksentijevic D, James AM, Krieg T, Hartley RC, Murphy MP.   +12 more
europepmc   +3 more sources

THE PREPARATION AND PROPERTIES OF THE PERSULFIDES OF HYDROGEN. [PDF]

Journal of the American Chemical Society, 1921
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Walton, James H., Parsons, Llewellyn B.
openaire   +2 more sources

Synthesis of Sulfides and Persulfides Is Not Impeded by Disruption of Three Canonical Enzymes in Sulfur Metabolism

Antioxidants, 2023
Reactive sulfur species, or persulfides and polysulfides, such as cysteine hydropersulfide and glutathione persulfide, are endogenously produced in abundance in both prokaryotes and eukaryotes, including mammals.
Qamarul Hafiz Zainol Abidin, Tomoaki Ida, Masanobu Morita, Tetsuro Matsunaga, Akira Nishimura, Minkyung Jung, Naim Hassan, Tsuyoshi Takata, Isao Ishii, Warren Kruger, Rui Wang, Hozumi Motohashi, Masato Tsutsui, Takaaki Akaike   +13 more
doaj   +1 more source

The Response of Acinetobacter baumannii to Hydrogen Sulfide Reveals Two Independent Persulfide-Sensing Systems and a Connection to Biofilm Regulation

mBio, 2020
Acinetobacter baumannii is an opportunistic nosocomial pathogen that is the causative agent of several serious infections in humans, including pneumonia, sepsis, and wound and burn infections. A.
Brenna J. C. Walsh, Jiefei Wang, Katherine A. Edmonds, Lauren D. Palmer, Yixiang Zhang, Jonathan C. Trinidad, Eric P. Skaar, David P. Giedroc   +7 more
doaj   +1 more source

Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species

Antioxidants, 2019
Hydrogen sulfide (H2S/HS⁻) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH).
Dayana Benchoam, Ernesto Cuevasanta, Matías N. Möller, Beatriz Alvarez   +3 more
doaj   +1 more source

Metabolic and Structural Insights into Hydrogen Sulfide Mis-Regulation in Enterococcus faecalis

Antioxidants, 2022
Hydrogen sulfide (H2S) is implicated as a cytoprotective agent that bacteria employ in response to host-induced stressors, such as oxidative stress and antibiotics.
Brenna J. C. Walsh, Sofia Soares Costa, Katherine A. Edmonds, Jonathan C. Trinidad, Federico M. Issoglio, José A. Brito, David P. Giedroc   +6 more
doaj   +1 more source

Direct Proteomic Mapping of Cysteine Persulfidation [PDF]

Antioxidants & Redox Signaling, 2020
Aims: Cysteine persulfidation (also called sulfhydration or sulfuration) has emerged as a potential redox mechanism to regulate protein functions and diverse biological processes in hydrogen sulfide (H2S) signaling. Due to its intrinsically unstable nature, working with this modification has proven to be challenging.
Ling, Fu, Keke, Liu, Jingyang, He, Caiping, Tian, Xiaobo, Yu, Jing, Yang   +5 more
openaire   +2 more sources