Results 101 to 110 of about 889,365 (318)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
School-based supervised therapy programs to improve asthma outcomes: current perspectives
Journal of Asthma and Allergy, 2018 Guadalupe Salazar, Geeta Tarwala, Marina Reznik Division of Academic General Pediatrics, Children’s Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA Background: Asthma is one of the most common chronic diseases of ...
Salazar G, Tarwala G, Reznik M
doaj
iMESc – an interactive machine learning app for environmental sciences
Frontiers in Environmental ScienceAs environmental sciences increasingly rely on complex datasets, machine learning (ML) has become crucial for identifying patterns and relationships. However, the integration of ML into workflows can pose challenges due to technical barriers or the time ...
Danilo Cândido Vieira +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Supervised Community Accommodation: Final Report
, 2019 The Queensland Department of Child Safety, Youth and Women (DCSYW) commissioned researchers from the Griffith Criminology Institute (GCI) to evaluate the Supervised Community Accommodation (SCA) program.
Wood, William, Hayes, Hennessey
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Persian Wordnet Construction using Supervised Learning
International Journal of Information and Communication Technology Research, 2017 This paper presents an automated supervised method for Persian wordnet construction. Using a Persian corpus and a bi-lingual dictionary, the initial links between Persian words and Princeton WordNet synsets have been generated.
Zahra Mousavi +2 more
doaj
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source