Results 81 to 90 of about 9,445,647 (302)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Modular synthesis of discrete controllers [PDF]
, 2007 This paper presents supervisory control theory in a process-algebraic setting, and proposes a way of synthesising modular supervisors that guarantee nonblocking.
Reeves, Steve +7 more
core +1 more source
Theory of Regions for Control Synthesis without Computing Reachability Graph
Applied Sciences, 2017 This paper addresses the design of Petri net (PN) supervisor using the theory of regions for forbidden state problem with a set of general mutual exclusion constraints. In fact, as any method of supervisory control based on reachability graph, the theory
Sadok Rezig, Zied Achour, Nidhal Rezg
doaj +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Market Newsletter 1/2023 [PDF]
, 2023 Wash trades prohibited as market manipulation 1 Financial Supervisory Authority reminds entities: ensure EMIR reporting of derivatives 3 Updates to the FIN-FSA’s prospectus inspection process 4 Financial reporting enforcement results in Europe 2022 6
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
, 2020 Director General’s review ....... 3 State of financial markets ....... 7 Supervision responsive to changes in operating environment ...... 11 FIN-FSA’s themes in 2019 Report on means to prevent excessive household indebtedness .......
core
Collision Avoidance for Parametric Railway Lines by Supervisor Control
IEEE AccessIn the present paper, two collision avoidance supervisor schemes are developed for a single line and one-way railway system, with a parametric number of stations and a parametric number of trains.
Fotis N. Koumboulis +4 more
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source