Results 131 to 140 of about 1,933,492 (363)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

EFFECT OF PROTEIN UNDEGRADED SUPPLEMENTATION ON PRODUCTION AND COMPOSITION OF MILK IN DAIRY COWS [PDF]

, 2010
This research was aimed to examine the effect of undegraded protein supplementation on nutrients intake, production and milk composition in dairy cows. The purpose of this research was to provide information on the undegraded protein supplementation to
Agus, A, Widyobroto, BP, Budhi, SPS
core  

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Improper Supplementation Habits of Folic Acid Intake by Hungarian Pregnant Women: Improper Recommendations [PDF]

, 2008
Background: Neural tube defects (NTDs) are some of the most common congenital anomalies. Proper folic acid supplementation is a dominant risk factor, which has been shown to decrease the incidence of NTDs.
Constantin, Tamás, Ponyi, Andrea, Hauser, Péter, Bognár, M., Schuler, Dezső, Jakab, Zsuzsanna, Garami, Miklós, Müller, Judit   +7 more
core  

The Effects of Multivitamin Supplementation on Diurnal Cortisol Secretion and Perceived Stress [PDF]

, 2013
Recent evidence suggests that dietary intake of vitamins, in particular the B-vitamins including B6, B9 and B12 may have a number of positive effects on mood and stress.
White, David J., David Camfield, White, DJ, David White, Katherine Cox, Cox, Katherine, Cox, Katherine H., Kras, M, Erin Fogg, Stough, C, Marni Kras, Sali, Avni, Kras, Marni, Sali, A, Scholey, Andrew, Fogg, E, Sarris, Jerome (R18802), Avni Sali, Wetherell, Mark A., Sarris, Jerome, Pipingas, Andrew, Fogg, Erin, Camfield, DA, Jerome Sarris, Mark Wetherell, Con Stough, Camfield, David, Scholey, AB, White, David, Pipingas, A, Andrew Pipingas, Wetherell, Mark, Cox, KHM, Sarris, J, Scholey, Andrew B., Stough, Con K., Andrew Scholey, Stough, Con, Wetherell, MA   +38 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Effect of Zinc Supplementation on Growth of Low Birth Weight Infants Aged 1–6 Mo in Ardabil, Iran [PDF]

Objective To assess the effect of zinc supplementation on growth of low birth weight (LBW) infants aged 1–6 mo. Methods LBW infants were enrolled at birth and randomly assigned to receive 5 mg elemental Zn per day (n=45) or placebo (n=45) until 6 mo of ...
امینی ثانی, نیره, شمشیرگران, سید مرتضی, Seyed Morteza Shamshirgaran, Manuchehr Barak, براک, منوچهر, Nayyereh Aminisani   +5 more
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Alterations in fecal microbiota composition by probiotic supplementation in healthy adults: a systematic review of randomized controlled trials

Genome Medicine, 2016
The effects of probiotic supplementation on fecal microbiota composition in healthy adults have not been well established. We aimed to provide a systematic review of the potential evidence for an effect of probiotic supplementation on the composition of ...
N. B. Kristensen, Thomas Bryrup, K. Allin, T. Nielsen, T. Hansen, O. Pedersen   +5 more
semanticscholar   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source