Results 51 to 60 of about 1,163,597 (254)
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Comprehensive analysis of genomic mutations, gene expression, DNA methylation, and pathway analysis of TCGA data was carried out to define cancer types in which proteasome subunits expression is associated with worse survival. Albeit the effect of specific proteasome subunits on cellular function, the main role of the proteasome is better evaluated ...
Ruba Al‐Abdulla +5 more
wiley +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
On the asymptotic normality of the Legendre-Stirling numbers of the second kind
, 2014 For the Legendre-Stirling numbers of the second kind asymptotic formulae are derived in terms of a local central limit theorem. Thereby, supplements of the recently published asymptotic analysis of the Chebyshev-Stirling numbers are established. Moreover,
Gawronski, Wolfgang +2 more
core +1 more source
Broccoli products supplemented beers provide a sustainable source of dietary sulforaphane
, 2022 Paola Sánchez‐Bravo +5 more
openalex +1 more source
Online supplementation for teaching evidence-based medicine: feasibility of a randomised-controlled trial [PDF]
, 2020 Marcy McCall +5 more
openalex +1 more source
Supplemental Material for The Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) Structured Interview for PTSD: A French Language Validation Study [PDF]
, 2021 Louise Gaston, Alain Brunet
openalex +1 more source
Molecular Oncology, EarlyView.Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner +6 more
wiley +1 more source
HELP-based matrices for stimuli-responsive controlled release of bioactive compounds [PDF]
, 2013 Direct delivery of bioactive substances to the sites of injury represents a key issue for therapies based on regenerative medicine and tissue repair [1].
Bandiera, A +4 more
core
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source