Results 111 to 120 of about 1,702,773 (334)

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

Molecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit, Thais Pereira‐Veiga, Helena Brauer, Michael Horn, Paula Nissen, Thomas Mair, Bente Siebels, Hannah Voß, Ruimeng Zhuang, Marie‐Therese Haider, Desiree Loreth, Margarita Iskhakova, Bele Lindemann, Julian Kött, Laure Cayrefourcq, Jasmin Wellbrock, Hartmut Schlüter, Klaus Pantel, Catherine Alix‐Panabières, Manfred Jücker   +19 more
wiley   +1 more source

Continuous supply chain collaboration : Road to achieve operational excellence [PDF]

Supply chain management (SCM) is becoming critical as firms recognize that competition is shifting from company versus company to supply chain versus supply chain.
Nakkeeran, Senthil kumar, Pugalendhi, Subburethina Bharathi   +1 more
core   +1 more source

Quantitative Evaluation of the Supply Chain Collaboration [PDF]

, 2007
Supply Chain Collaboration (SCC) is defined as a status of optimized overall utility of the supply chain under the precondition of satisfactions of each supply chain member.
Linlin, Cui, Yueting, Chai
core  

Study on Early Warning Methods for Shipping Input Risks Under Consideration of Public Health Events

Applied Sciences
The rapid expansion of economic globalization and trade has led to a sharp increase in the shipping investment risks currently faced by cities around the world.
Zhanxin Ma, Xiyu Zheng, Jiachao Wu, Dongping Pu   +3 more
doaj   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

Ubiquitination of transcription factors in cancer: unveiling therapeutic potential

Molecular Oncology, EarlyView.
In cancer, dysregulated ubiquitination of transcription factors contributes to the uncontrolled growth and survival characteristics of tumors. Tumor suppressors are degraded by aberrant ubiquitination, or oncogenic transcription factors gain stability through ubiquitination, thereby promoting tumorigenesis.
Dongha Kim, Hye Jin Nam, Sung Hee Baek
wiley   +1 more source

The impact of Green Information Systems on sustainable supply chain and organizational performance [PDF]

, 2013
This paper reports about a research in progress focusing on the impact of green information systems on sustainable supply chain performance. Green information systems, supply chains and their relation to sustainability and performance measurement are ...
Aktas, E, Ogunyemi, T
core  

Liner Schedule Design under Port Congestion: A Container Handling Efficiency Selection Mechanism

Journal of Marine Science and Engineering
Port congestion significantly impacts the reliability of container ship schedules. However, the existing research often treats vessel time in port as a random variable, failing to systematically consider the complex impact of port congestion on ship ...
Haibin Qu, Xudong Wang, Lingpeng Meng, Chuanfeng Han   +3 more
doaj   +1 more source

Supply Chain Management Based on Market Mechanism in Virtual Enterprise [PDF]

, 1999
Toshiya Kaihara
openalex   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source