Results 111 to 120 of about 5,758,776 (359)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

Supply chain resilience : interconnectedness of disruptions, strategies and outcomes in the South African FMCG industry [PDF]

open access: yesThe Retail and Marketing Review, 2020
Background: Organisations face greater competition and exposure to disruptions and risks due to an increase in globalisation, and as a result, they must continuously seek strategies to improve their supply chain resilience (SCRES).
SM Magagula, A Meyer, W Niemann
doaj  

Risk management in organic coffee supply chains : testing the usefulness of critical risk models [PDF]

open access: yes, 2011
This report documents the findings of the analysis of the supply chain of organic coffee from Uganda to the Netherlands using a Chain Risk Model (CRM). The CRM considers contamination of organic coffee with chemicals as a threat for the supply chain, and
Benninga, J.   +2 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Analyzing Project Management Maturity Level in Indonesia

open access: yesThe South East Asian Journal of Management, 2013
Project management has been generally known and increasingly used by many organizations to gain competitive advantage. In this context, many studies have proposed maturity models to evaluate how project management knowledge has been deployed effectively
Eliot Simangunsong   +1 more
doaj   +1 more source

FedEx Case Study: Links in the Chain [PDF]

open access: yes
Supply chain management improves competition by controlling costs and shortening product delivery cycles.supply chain, global supply chain, FedEx, supply chain management, Tennessee ...
Scott Gardner
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

Study on Early Warning Methods for Shipping Input Risks Under Consideration of Public Health Events

open access: yesApplied Sciences
The rapid expansion of economic globalization and trade has led to a sharp increase in the shipping investment risks currently faced by cities around the world.
Zhanxin Ma   +3 more
doaj   +1 more source

GResilient index to assess the greenness and resilience of the automotive supply chain [PDF]

open access: yes
Purpose: The purpose of this paper is to suggest an Index entitled GResilient Index to assess the greenness and resilience of the automotive companies and corresponding supply chain. Design/methodology/approach: An integrated assessment model is proposed
Azevedo, Susana G.   +3 more
core  

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