Results 111 to 120 of about 1,809,313 (357)

Identification and classification of risks in the New Zealand plywood supply chain : thesis presented in fulfilment of the requirements for the degree of Master of Supply Chain Management at Massey University, Palmerston North, New Zealand [PDF]

open access: yes, 2016
Activities in the supply chain cover a wide-ranging area from upstream to downstream in order to deliver products and services to end customers. Because of the supply chain’s width and scope, the activities in it consume a substantial portion of total
Kusumamurni, Pimpin
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Supply chain resilience : interconnectedness of disruptions, strategies and outcomes in the South African FMCG industry [PDF]

open access: yesThe Retail and Marketing Review, 2020
Background: Organisations face greater competition and exposure to disruptions and risks due to an increase in globalisation, and as a result, they must continuously seek strategies to improve their supply chain resilience (SCRES).
SM Magagula, A Meyer, W Niemann
doaj  

GResilient index to assess the greenness and resilience of the automotive supply chain [PDF]

open access: yes
Purpose: The purpose of this paper is to suggest an Index entitled GResilient Index to assess the greenness and resilience of the automotive companies and corresponding supply chain. Design/methodology/approach: An integrated assessment model is proposed
Azevedo, Susana G.   +3 more
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

open access: yesMolecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu   +18 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Study on Early Warning Methods for Shipping Input Risks Under Consideration of Public Health Events

open access: yesApplied Sciences
The rapid expansion of economic globalization and trade has led to a sharp increase in the shipping investment risks currently faced by cities around the world.
Zhanxin Ma   +3 more
doaj   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

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