Results 111 to 120 of about 1,832,123 (358)

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Double Deep Q-Network-Based Solution to a Dynamic, Energy-Efficient Hybrid Flow Shop Scheduling System with the Transport Process

Systems
In this paper, a dynamic energy-efficient hybrid flow shop (TDEHFSP) scheduling model is proposed, considering random arrivals of new jobs and transport by transfer vehicles.
Qinglei Zhang, Huaqiang Si, Jiyun Qin, Jianguo Duan, Ying Zhou, Huaixia Shi, Liang Nie   +6 more
doaj   +1 more source

Analyzing Project Management Maturity Level in Indonesia

The South East Asian Journal of Management, 2013
Project management has been generally known and increasingly used by many organizations to gain competitive advantage. In this context, many studies have proposed maturity models to evaluate how project management knowledge has been deployed effectively
Eliot Simangunsong, Elisabeth Novira Da Silva   +1 more
doaj   +1 more source

TEMPERATURE MAPPING OF FRESH FISH SUPPLY CHAINS – AIR AND SEA TRANSPORT [PDF]

, 2011
Nga Mai, Björn Margeirsson, Sveinn Margeirsson, Sigurður G. Bogason, Sjöfn Sigurgísladóttir, Sigurjón Arason   +5 more
openalex   +1 more source

Supply Chain Management Berbasis Layanan: Desain Dan Implementasi Prototipe Sistem [PDF]

, 2012
Supply Chain Management (SCM) adalah sebuah konsep pengaturan aliran proses perdagangan yang menghubungkan antara produsen, supplier, dan konsumen secara langsung.
Alfian, R. (Rakhmat), Budiasto, J. (Jarot), Hilman, M. H. (Muhammad), Sarika, I. (Ika), Setiadi, F. (Farisya)   +4 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Benchmarking criteria for evaluating third-party logistics providers in South Africa

Journal of Transport and Supply Chain Management, 2017
Background: In South Africa, deemed the ‘gateway to Africa’, there is limited evidence of the existence of a survey ranking third-party logistics providers (3PLs).
Claudia Karrapan, Mndeni Sishange, Elana Swanepoel, Peter J. Kilbourn   +3 more
doaj   +1 more source

LARGE SCALE SUPPLY CHAIN NETWORK DESIGN: AN EFFECTIVE HEURISTIC APPROACH [PDF]

, 2023
Juan Leandro Andres Parra Galvez, Denis Borenstein   +1 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Towards a business model for sustainable supply chain management [PDF]

, 2013
Designers make decisions that ultimately impact on both the economic, environmental and social performance of the products and process, and many of these costs and impacts occur across the supply chain.
Ball, Peter D., Pimenta, Handson
core