Results 81 to 90 of about 3,300,319 (310)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The structure of cross-ventilation flow in an isolated cylindrical building: Numerical study

Energy and Built Environment
Cross-ventilation serves as an efficient means to expel pollutants and heat from buildings, requiring no energy consumption due to variations in wind pressure. The structure of the cross-ventilation flow significantly influences ventilation effectiveness.
Puxian Ding, Di Fan, Ye Feng, Shiming Liu, Xiaoqing Zhou   +4 more
doaj   +1 more source

Cross-departmental collaboration in strategic sourcing as a catalyst for supplier development: The case of Eskom

Acta Commercii, 2017
Objective: The objective was to analyse the integration of and collaboration between strategic sourcing and supplier development at Eskom, South Africa’s primary electricity supplier, and to determine how strategic sourcing can be a catalyst for supplier
Mzoxolo E. Mbiko, Tatenda Mbara, Elana Swanepoel   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Study on the Multi-Equipment Integrated Scheduling Problem of a U-Shaped Automated Container Terminal Based on Graph Neural Network and Deep Reinforcement Learning

Journal of Marine Science and Engineering
Intelligent Guided Vehicles (IGVs) in U-shaped automated container terminals (ACTs) have longer travel paths than those in conventional vertical layout ACTs, and their interactions with double trolley quay cranes (DTQCs) and double cantilever rail cranes
Qinglei Zhang, Yi Zhu, Jiyun Qin, Jianguo Duan, Ying Zhou, Huaixia Shi, Liang Nie   +6 more
doaj   +1 more source

Forecast accuracy in demand planning: A fast-moving consumer goods case study

Journal of Transport and Supply Chain Management, 2019
Background: An established South African fast-moving consumer goods (FMCG) manufacturer, Company A, sought to address an underperforming supply chain through an attempt to improve demand planning accuracy.
Lisa M. Basson, Peter J. Kilbourn, Jackie Walters   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Integrating Healthcare Processes Through Supply Chain Principles

, 2023
Healthcare supply chain has increasingly attracted the attention of scholars, researchers, government officials, and clinicians as one of the primary strategies in their efforts to reduce healthcare costs while improving quality.
Altabsh, Mariam
core  

Automating supply chains

IEEE Internet Computing, 2001
A recent study found that supply-chain problems cost companies between 9 and 20 percent of their value over a six-month period (T.J. Becker, 2000). The problems range from part shortages to poorly utilized plant capacity. When you place this in the context of the overall business-to-business (B2B) market expected to reach US$7 trillion by 2004 (37 ...
Huhns, Michael N., Stevens, Larry M.
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source