Results 71 to 80 of about 561,297 (356)

TRPM8 levels determine tumor vulnerability to channel agonists

Molecular Oncology, EarlyView.
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo, Francesco Giuseppe Carbone, Kristi Buzo, Nicole Annesi, Sacha Genovesi, Annalisa Lorenzato, Karen Widmann, Michela Libergoli, Elisa Marmocchi, Giovanni Bertalot, Alberto Brolese, Mauro Giulio Papotti, Luca Molinaro, Orazio Caffo, Mattia Barbareschi, Alberto Bardelli, Alessandro Romanel, Sabrina Arena, Andrea Lunardi   +18 more
wiley   +1 more source

The Influence of Supply Chain Digitalization on Integration and Agility in Company Performance

Indonesian Interdisciplinary Journal of Sharia Economics
This study aims to analyze the effect of supply chain digitalization on integration and agility in company performance. Supply chain digitalization is considered a key factor in improving operational efficiency and effectiveness.
Ikrima Ikrima, Wahyuningsih Santosa, Triwulandari Satitidjati Dewayana   +2 more
doaj   +1 more source

The impact of Green Information Systems on sustainable supply chain and organizational performance [PDF]

, 2013
This paper reports about a research in progress focusing on the impact of green information systems on sustainable supply chain performance. Green information systems, supply chains and their relation to sustainability and performance measurement are ...
Aktas, E, Ogunyemi, T
core  

Integrating the Supply Chain … 25 years on [PDF]

International Journal of Physical Distribution & Logistics Management, 2016
Purpose – Twenty-five years ago IJPDLM published “Integrating the Supply Chain” (Stevens, 1989). The purpose of that original work was to examine the state-of-the-art in supply chain management (SCM). There have been substantial changes to the landscape within which supply chains function and changes to supply chains ...
Mark Johnson, Graham C. Stevens
openaire   +2 more sources

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

Molecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald, Anna M. Reagan, Charles J. Bailey, Mei Gao, Muqiang Gao, Angelica L. Solomon, Michael J. Cavnar, Prakash K. Pandalai, Mautin T. Barry‐Hundeyin, Megan M. Harper, Justin A. Rueckert, Ángela Turrero, Araceli Tobio, Anxo Vidal, Daniel Roca‐Lema, Elia Álvarez‐Coiradas, Pablo Garrido, Laureano Simón, Joseph Kim   +18 more
wiley   +1 more source

Pengaruh Organizational Culture Terhadap Entrepreneurial Intensity Dan Supply Chain Integration Dalam Rangka Memperoleh Competitive Advantage Pada Perusahaan Jasa Keuangan Di Surabaya [PDF]

, 2014
Penelitian ini bertujuan untuk mengetahui pengaruh langsung yang signifikan dari organizational culture terhadap entrepreneurial intensity, entrepreneurial intensity terhadap competitive advantage, organizational culture terhadap supply chain integration,
Caroline, A. (Anita)
core  

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Efficiency and Integration in the Food Supply Chain

International Journal on Food System Dynamics, 2013
Due to the nature of the food supply chain, an increase of the integration's degree in the chain may be an important aspect in the context of increasing the efficiency of agri-food companies. Therefore, exploring the relationships among these variables was found as an important research area and adopted as the goal of the paper.
Jarzebowski, Sebastian, Bezat-Jarzębowska, Agnieszka, Klepacki, Bogdan   +2 more
openaire   +4 more sources

A DIA‐MS‐based proteomics approach to find potential serum prognostic biomarkers in glioblastoma patients

Molecular Oncology, EarlyView.
A DIA‐MS‐based proteomics analysis of serum samples from GB patients and healthy controls showed that high levels of IL1R2 and low levels of CRTAC1 and HRG in serum are associated with poor survival outcomes for GB patients. These circulating proteins could serve as biomarkers for the prediction of outcome in patients with GB.
Anne Clavreul, François Guillonneau, Odile Blanchet, Hamza Lasla, Audrey Rousseau, Catherine Guette, Alice Boissard, Cécile Henry, Morgan Dhondt, Pascal Jézéquel, Philippe Menei, Jean‐Michel Lemée   +11 more
wiley   +1 more source

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source