Results 71 to 80 of about 611,924 (357)
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
The Influence of Supply Chain Digitalization on Integration and Agility in Company Performance
Indonesian Interdisciplinary Journal of Sharia EconomicsThis study aims to analyze the effect of supply chain digitalization on integration and agility in company performance. Supply chain digitalization is considered a key factor in improving operational efficiency and effectiveness.
Ikrima Ikrima +2 more
doaj +1 more source
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
On Theory in Supply Chain Uncertainty and its Implications for Supply Chain Integration [PDF]
, 2016 This article develops a theoretical conceptualization of supply chain uncertainty, based on the foundation provided by contingency theory, classical organization theory, and information processing theory. We develop a theoretical analogy between a supply
Flynn, Barbara B. +2 more
core +1 more source
Supply Chain Control: A Theory of Vertical Integration [PDF]
Improving a company's bargaining position is often cited as a chief motivation to vertically integrate with suppliers. This paper expands on that view in building a new theory of vertical integration.
Ursino, Giovanni
core +4 more sources
The role of supply chain agility in the effectiveness of supply integration on new product innovation performance [PDF]
رویکردهای نوین در مدیریت و بازاریابیThe aim of this research is to study and investigate the impact of supply chain integration dimensions on new product innovation performance through supply chain agility in Pegah Pasteurized Dairy Company in the northwest region of Iran.
elahe nouri +3 more
doaj +1 more source
The New Products Development: Effect of integration between Industry 4.0 and Supply Chain Management. [PDF]
, 2023 José Rodolfo Sorto-Bueso +2 more
openalex +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
SUPPLY CHAIN INTEGRATION IN THE FOOD AND CONSUMER GOODS INDUSTRIES [PDF]
The interorganizational structures necessary to implement and achieve the logistical performance improvements identified in the Efficient Consumer Response (ECR) initiative and related supply chain management concepts are difficult to develop.
Frankel, Robert +5 more
core +1 more source