Results 101 to 110 of about 4,116,789 (307)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Effects of intra-aortic balloon pump on cerebral blood flow during peripheral venoarterial extracorporeal membrane oxygenation support [PDF]

, 2014
BACKGROUND: The addition of an intra-aortic balloon pump (IABP) during peripheral venoarterial extracorporeal membrane oxygenation (VA ECMO) support has been shown to improve coronary bypass graft flows and cardiac function in refractory cardiogenic ...
Chun-jing Jiang, Feng Yang, Hong Wang, Jia-lin Xing, Ming Jia, Xiao-tong Hou, Xing Hao, Yuan Liu, Zai-shen Jia, Zheng Wang   +9 more
core   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Effectiveness of Computer Automation for the Diagnosis and Management of Childhood Type 2 Diabetes A Randomized Clinical Trial [PDF]

, 2017
Importance Type 2 diabetes (T2D) is increasingly common in young individuals. Primary prevention and screening among children and adolescents who are at substantial risk for T2D are recommended, but implementation of T2D screening practices in the ...
Carroll, Aaron E., Downs, Stephen M., Dugan, Tamar M., Hannon, Tamara S., McKee, Steven J., Saha, Chandan K.   +5 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Family-led rehabilitation after stroke in India (ATTEND): a randomised controlled trial [PDF]

, 2017
Background: Most people with stroke in India have no access to organised rehabilitation services. The effectiveness of training family members to provide stroke rehabilitation is uncertain.
Aaron, S, Alim, M, Alladi, S, Anbalagan, P, Anderson, CS, Andrias, A, Aneesh, V, ATTEND Collaborative Group, Bernhardt, J, Billot, L, Biswas, B, Borah, NC, Bordoloi, K, Byrne, D, Chakraborty, D, Chakraborty, SS, Chilappagari, S, COLLABORATORS, Das, B, Das, K, Dehingia, K, Dhanya, TS, Dinesh, S, Donnelly, P, Felix, C, Forster, A, George, J, Ghose, M, Gohain, P, Hackett, ML, Halprashanth, DS, Hankey, G, Harvey, LA, Jalapu, VRR, Jan, S, Jangir, A, Jeyaseelan, L, John, L, Karunanithi, A, Katoch, C, Kaul, S, Kaur, T, Kaura, S, Khanna, MC, Khullar, S, Khurana, D, Kirubakaran, P, Koundal, H, Krishna, R, Krishna, R, Langhorne, P, Li, Q, Lindley, RI, Liu, H, Madhusudhan, BK, Manchireddy, K, Maulik, PK, Mehndiratta, MM, Mehta, S, Murthy, GVS, Mysore, J, Nambiar, V, Nandini, C, Narang, GS, Padma, MV, Pandian, JD, Prabhakar, AT, Rajan, A, Ramya, I, Rao, TNM, Reddy, KV, Reddy, NM, Roy, J, Santhosh, V, Sebastian, I, Shamanna, BR, Shibi, BS, Singh, P, Sivasambath, S, Sreedharan, S, Steley, S, Sulaiman, SMS, Sureshbabu, S, Sylaja, PN, Syrigapu, A, Thambu, DS, Thangaraj, A, Thomas, N, Thomas, NJ, Thouman, S, Tugnawat, DK, Verma, SJ, Vijaya, P, Walker, MF   +93 more
core   +4 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Psychometric properties of the Polish version of the eight-item Morisky Medication Adherence Scale in hypertensive adults. [PDF]

, 2016
Low adherence to pharmacological treatment is often associated with poor blood pressure control, but identification of nonadherent patients in outpatient settings is difficult.
Chudiak, Anna, Dudek, Krzysztof, Jankowska-Polanska, Beata, Morisky, Donald E, Szymanska-Chabowska, Anna, Uchmanowicz, Izabella   +5 more
core   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

A Retrospective Match Controlled Study of Supersaturated Calcium Phosphate Oral Rinse vs. Supportive Care for Radiation Induced Oral Mucositis

Journal of Cancer Therapy, 2012
Oral mucositis is a common morbidity induced by radiation therapy and chemo-radiotherapy for head and neck malignancies. This often results in treatment delays, premature treatment cessation and increased cost. New treatments of oral mucositis are emerging but effective remedies remain limited.
Curtis T. Miyamoto, Jessica Wobb, Bizhan Micaily, Shidong Li, Mohan P. Achary   +4 more
openaire   +2 more sources