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Nonsense suppression therapies in human genetic diseases
Cellular and Molecular Life Sciences, 2021About 11% of all human disease-associated gene lesions are nonsense mutations, resulting in the introduction of an in-frame premature translation-termination codon (PTC) into the protein-coding gene sequence. When translated, PTC-containing mRNAs originate truncated and often dysfunctional proteins that might be non-functional or have gain-of-function ...
Patrícia Martins-Dias, Luísa Romão
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Genetic Control of Lymphocytes Suppression
The Journal of Immunology, 1978Abstract Con A-activated cells from old NZB mice were found capable of inhibiting the polyclonal response of cells from young NZB and BALB/c animals. Furthermore, Con A-preactivated spleen cells from young NZB and BALB/c mice did not significantly affect the response of spleen cells from old NZB mice.
Daniele Primi +2 more
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Genetic Strategies of Tumor Suppression
American Review of Respiratory Disease, 1990Abstract The evaluation of the cancer cell is a complex multigene process. Tumor suppressor genes that are lost or inactivated, as well as genes that are overexpressed, play key roles in tumor progression. The identification of overexpressed genes has been expedited by the presence of transforming genes in some animal retroviruses ...
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Genetic Control of Immune Suppression
The Journal of Immunology, 1978Abstract Suppressor T cells induced in vitro by high concentrations of antigen release suppressor factors into their medium if incubated for 24 hours with antigen. Since there are reports that extracts of suppressor cells are related to immune response gene function, the capacity of responder or nonresponder strains to produce suppressor
Sirkka Kontiainen +2 more
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Genetic regulation of testosterone-induced immune suppression
Cellular Immunology, 1987Genes in the major histocompatibility complex (H-2) of the mouse control several immune functions as well as various facets of testosterone (Te) physiology. In order to study the genetic control of Te-induced immune suppression, complete Freund's adjuvant (CFA; containing Mycobacteria tuberculosis) was administered parenterally to several mouse strains
S A, Ahmed, N, Talal, P, Christadoss
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Genetic Studies in Familial Aldosteronism Not Suppressible by Dexamethasone
International Journal on Disability and Human Development, 2000Two pairs of sisters with primary aldosteronism are presented. In each pair there was one of the siblings with a unilateral adrenal adenoma and the other with bilateral adrenal hyperplasia. A 4-day dexamethasone trial (2 mg/day) caused a decrease but not a suppression of aldosterone in all patients.
FALLO, FRANCESCO +8 more
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Genetic Suppression of Tumor Formation
1985Publisher Summary Genomic changes of all kinds, ranging from base substitutions, deletions, duplications, amplifications, and rearrangements, are characteristic of malignant cells. With respect to genetic suppression of tumor formation, genomic changes can play a crucial role in eliminating or silencing suppressor genes during tumorigenesis.
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Suppression of quasiperiodic thermoacoustic oscillations via genetic programming
INTER-NOISE and NOISE-CON Congress and Conference Proceedings, 2023We use genetic programming (GP) to discover data-driven control laws for the suppression of quasiperiodic oscillations in a prototypical thermoacoustic system. We rank the control laws based on a predefined cost function that accounts for the pressure amplitude and the actuation effort.
B YIN +4 more
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Nonsense suppression therapies in ocular genetic diseases
Cellular and Molecular Life Sciences, 2015Premature termination codons (PTCs) are caused by nonsense mutations and this leads to either degradation of the mutant mRNA template by nonsense-mediated decay (NMD) or the production of a non-functional, truncated polypeptide. PTCs contribute significantly to inherited human diseases including ocular disorders.
Xia, Wang, Cheryl Y, Gregory-Evans
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Genetic Suppression of Polyglutamine Toxicity in Drosophila
Science, 2000A Drosophila model for Huntington's and other polyglutamine diseases was used to screen for genetic factors modifying the degeneration caused by expression of polyglutamine in the eye. Among 7000 P-element insertions, several suppressor strains were isolated, two of which led to the discovery of the suppressor genes
Kazemi-Esfarjani, Parsa, Benzer, Seymour
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