Results 221 to 230 of about 424,245 (266)
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Genetic Strategies of Tumor Suppression
American Review of Respiratory Disease, 1990Abstract The evaluation of the cancer cell is a complex multigene process. Tumor suppressor genes that are lost or inactivated, as well as genes that are overexpressed, play key roles in tumor progression. The identification of overexpressed genes has been expedited by the presence of transforming genes in some animal retroviruses ...
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Genetic Control of Lymphocytes Suppression
The Journal of Immunology, 1978Abstract Con A-activated cells from old NZB mice were found capable of inhibiting the polyclonal response of cells from young NZB and BALB/c animals. Furthermore, Con A-preactivated spleen cells from young NZB and BALB/c mice did not significantly affect the response of spleen cells from old NZB mice.
Daniele Primi +2 more
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Genetic Control of Immune Suppression
The Journal of Immunology, 1978Abstract Suppressor T cells induced in vitro by high concentrations of antigen release suppressor factors into their medium if incubated for 24 hours with antigen. Since there are reports that extracts of suppressor cells are related to immune response gene function, the capacity of responder or nonresponder strains to produce suppressor
Sirkka Kontiainen +2 more
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Genetic Suppression of Tumor Formation
1985Publisher Summary Genomic changes of all kinds, ranging from base substitutions, deletions, duplications, amplifications, and rearrangements, are characteristic of malignant cells. With respect to genetic suppression of tumor formation, genomic changes can play a crucial role in eliminating or silencing suppressor genes during tumorigenesis.
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Genetic regulation of testosterone-induced immune suppression
Cellular Immunology, 1987Genes in the major histocompatibility complex (H-2) of the mouse control several immune functions as well as various facets of testosterone (Te) physiology. In order to study the genetic control of Te-induced immune suppression, complete Freund's adjuvant (CFA; containing Mycobacteria tuberculosis) was administered parenterally to several mouse strains
S A, Ahmed, N, Talal, P, Christadoss
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Genetic Studies in Familial Aldosteronism Not Suppressible by Dexamethasone
International Journal on Disability and Human Development, 2000Two pairs of sisters with primary aldosteronism are presented. In each pair there was one of the siblings with a unilateral adrenal adenoma and the other with bilateral adrenal hyperplasia. A 4-day dexamethasone trial (2 mg/day) caused a decrease but not a suppression of aldosterone in all patients.
FALLO, FRANCESCO +8 more
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Suppression of pattern-forming instabilities by genetic optimization
Physical Review E, 2016We propose a versatile "stabilization on demand" method for the suppression of modulation instability in oscillatory spatially extended nonlinear systems, based on a genetically optimized multifrequency spatiotemporal modulation of the potential. The method, which ensures full stabilization even for very strong nonlinearities, forms a powerful tool ...
Kumar, Shubham +3 more
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Nonsense suppression therapies in ocular genetic diseases
Cellular and Molecular Life Sciences, 2015Premature termination codons (PTCs) are caused by nonsense mutations and this leads to either degradation of the mutant mRNA template by nonsense-mediated decay (NMD) or the production of a non-functional, truncated polypeptide. PTCs contribute significantly to inherited human diseases including ocular disorders.
Xia, Wang, Cheryl Y, Gregory-Evans
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Genetic studies on temperature sensitive nonsense suppression
Molecular and General Genetics MGG, 1970Temperature sensitive suppression of nonsense mutations has been obtained, in E. coli, by inducing a mutation in the suppressor gene su-4, a structural gene for a tyrosine tRNA. In this mutant while no suppression is detectable at 42°C it is always present at lower temperatures.
E, Gallucci, G, Pacchetti, S, Zangrossi
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A global genetic suppression network
Science, 2016Yeast Genetics The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen et al. generated a large-scale suppression network in yeast. The data set
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