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Genetic studies on temperature sensitive nonsense suppression
Molecular and General Genetics MGG, 1970Temperature sensitive suppression of nonsense mutations has been obtained, in E. coli, by inducing a mutation in the suppressor gene su-4, a structural gene for a tyrosine tRNA. In this mutant while no suppression is detectable at 42°C it is always present at lower temperatures.
E, Gallucci, G, Pacchetti, S, Zangrossi
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A global genetic suppression network
Science, 2016Yeast Genetics The genetic background of an organism can influence the overall effects of new genetic variants. Some mutations can amplify a deleterious phenotype, whereas others can suppress it. Starting with a literature survey and expanding into a genomewide assay, van Leeuwen et al. generated a large-scale suppression network in yeast. The data set
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Genetic suppression of malignancy.
IARC scientific publications, 1989Genetic tumours of Xiphophorus are one of the classical experimental models that underline the concept that cancers develop as a result of abnormal gene expression. Formal genetics has indicated that cancer development in Xiphophorus starts when oncogenes are expressed abnormally due to elimination of tumour suppressor genes.
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Genetic basis of BCG-induced suppression of delayed hypersensitivity
Nature, 1981BCG can either act as an adjuvant to potentiate immunological responses or, in some cases, can induce suppression. The reasons for these differential activities are not clear but may include routes and doses of administration, as well as variable host reactivity to the agent.
Schrier, D J +3 more
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Genetically restricted antigen presentation for immunological tolerance and suppression
Nature, 1984The activation of some subsets of T cells requires the recognition of antigen in association with self Ia determinants. It is not clear, however, whether this is also necessary for the induction of unresponsiveness and the active suppression of hapten-specific T cells.
A, Lowy +4 more
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Suppression of Avian Influenza Transmission in Genetically Modified Chickens
Science, 2011Transgenic birds expressing a short hairpin RNA that blocks viral polymerase hinder influenza transmission.
Jon, Lyall +10 more
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A genetic basis for tumour suppression.
Ciba Foundation symposium, 1989The technique of somatic cell hybridization has established the phenomenon of tumour suppression and provided evidence for a genetic basis for suppression. Further refinements aimed at eventually identifying 'tumour suppressor' genes include the use of monochromosome transfer via microcell hybridization.
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Cancer genetics and cancer suppression.
Cancer detection and prevention, 1990Identification of normal growth and differentiation-inducing proteins and how they interact in normal development has made it possible to identify the molecular basis of normal development and the mechanisms that uncouple growth and differentiation so as to produce malignant cells.
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Genetic testing in prostate cancer management: Considerations informing primary care
Ca-A Cancer Journal for Clinicians, 2022Veda N Giri +2 more
exaly
Genetic principles of tumor suppression
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1989openaire +2 more sources