Results 51 to 60 of about 749,487 (299)

Genetic Suppression of Seizure Susceptibility inDrosophila [PDF]

Journal of Neurophysiology, 2001
Despite the frequency of seizure disorders in the human population, the genetic and physiological basis for these defects has been difficult to resolve. Although many genetic defects that cause seizure susceptibility have been identified, the defects involve disparate biological processes, many of which are not neural specific.
D, Kuebler, H, Zhang, X, Ren, M A, Tanouye   +3 more
openaire   +2 more sources

HIV controllers: hope for a functional cure

Frontiers in Immunology
Elite controllers (ECs) and post-treatment controllers (PTCs) represent important models for achieving a functional cure for HIV. This review synthesizes findings from immunological, genetic, and virological studies to compare the mechanisms underlying ...
Zhuoya Deng, Zhuoya Deng, Hongxia Yan, Hongxia Yan, Olivier Lambotte, Christiane Moog, Christiane Moog, Bin Su, Bin Su, Bin Su   +9 more
doaj   +1 more source

Catastrophic senescence of the Pacific salmon without mutation-accumulation

, 2001
We derive catastrophic senescence of the Pacific salmon from an aging model which was recently proposed by Stauffer. The model is based on the postulates of a minimum reproduction age and a maximal genetic lifespan.
Meyer-Ortmanns, Hildegard
core   +1 more source

Interactions between Type III receptor tyrosine phosphatases and growth factor receptor tyrosine kinases regulate tracheal tube formation in Drosophila [PDF]

, 2012
The respiratory (tracheal) system of the Drosophila melanogaster larva is an intricate branched network of air-filled tubes. Its developmental logic is similar in some ways to that of the vertebrate vascular system.
Jeon, Mili, Scott, Matthew P., Zinn, Kai
core   +3 more sources

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Attenuation of nonsense-mediated mRNA decay enhances in vivo nonsense suppression. [PDF]

PLoS ONE, 2013
Nonsense suppression therapy is an approach to treat genetic diseases caused by nonsense mutations. This therapeutic strategy pharmacologically suppresses translation termination at Premature Termination Codons (PTCs) in order to restore expression of ...
Kim M Keeling, Dan Wang, Yanying Dai, Srinivasan Murugesan, Balachandra Chenna, Jeremy Clark, Valery Belakhov, Jeyakumar Kandasamy, Sadanandan E Velu, Timor Baasov, David M Bedwell   +10 more
doaj   +1 more source

Dissection of Structural Reorganization of Wheat 5B Chromosome Associated With Interspecies Recombination Suppression

Frontiers in Plant Science, 2022
Chromosomal rearrangements that lead to recombination suppression can have a significant impact on speciation, and they are also important for breeding. The regions of recombination suppression in wheat chromosome 5B were identified based on comparisons ...
Elena Salina, Elena Salina, Alexander Muterko, Antonina Kiseleva, Antonina Kiseleva, Zhiyong Liu, Abraham Korol   +6 more
doaj   +1 more source

BNYVV-derived dsRNA confers resistance to rhizomania disease of sugar beet as evidenced by a novel transgenic hairy root approach [PDF]

, 2010
Agrobacterium rhizogenes-transformed sugar beet hairy roots, expressing dsRNA from the Beet necrotic yellow vein virus replicase gene, were used as a novel approach to assess the efficacy of three intron-hairpin constructs at conferring resistance to ...
Pavli, R., Panopoulos, N.J., Goldbach, R.W., Skaracis, G.N.   +3 more
core   +2 more sources

Genetic drift suppresses bacterial conjugation in spatially structured populations [PDF]

Biophysical Journal, 2014
ABSTRACTConjugation is the primary mechanism of horizontal gene transfer that spreads antibiotic resistance among bacteria. Although conjugation normally occurs in surface-associated growth (e.g., biofilms), it has been traditionally studied in well-mixed liquid cultures lacking spatial structure, which is known to affect many evolutionary and ...
Freese, PD, Korolev, KS, Jimenez, JI, Chen, IA   +3 more
openaire   +5 more sources

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source