Results 161 to 170 of about 2,809,202 (330)

The Assessment of Fire Suppression Capability for the Ammonium Dihydrogen Phosphate Dry Powder of Commercial Fire Extinguishers

, 2014
ChungHwei Su, Chan‐Cheng Chen, Horng‐Jang Liaw, ShiuanCheng Wang   +3 more
openalex   +1 more source

Influence of transdermal rotigotine on ovulation suppression by a combined oral contraceptive [PDF]

, 2009
Marina Braun, Jan‐Peer Elshoff, Jens‐Otto Andreas, Louise Ischen Müller, Rolf D. Horstmann   +4 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Anti-colitis effect of Lactobacillus sakei K040706 via suppression of inflammatory responses in the dextran sulfate sodium-induced colitis mice model

, 2017
Seung‐Hwan Seo, Ji‐Sun Shin, Wooseok Lee, Young Kyoung Rhee, Chang‐Won Cho, Hee‐Do Hong, Kyung‐Tae Lee   +6 more
openalex   +2 more sources

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Tuberous Sclerosis Complex Suppression in Cerebellar Development and Medulloblastoma: Separate Regulation of Mammalian Target of Rapamycin Activity and p27Kip1 Localization

, 2009
Bobby Bhatia, Paul A. Northcott, Dolores Hambardzumyan, Baskaran Govindarajan, Daniel J. Brat, Jack L. Arbiser, Eric C. Holland, Michael D. Taylor, Anna Marie Kenney   +8 more
openalex   +1 more source

In Vitro Suppression of Soilborne Plant Pathogens by Coir [PDF]

, 2009
Naveen Hyder, James J. Sims, Stephen N. Wegulo   +2 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Interaction Effect of Cover Crop Residues and Hand Weeding of Weeds on Iceberg Lettuce (Lactuca sativa var. Iceberg) Yield

Ikufīziyuluzhī-i Giyāhān-i Zirā̒ī
High quality standards in vegetables is one of the most important expectation of consumers presence of weeds would also reduce the quantity and quality of crops produced. Use of cover crops could be an environmentally friendly alternative to conventional
Fatemeh Ahmadnia, Ali Ebadi, Mohammad Gudarzi   +2 more
doaj