Results 11 to 20 of about 1,138,079 (262)
Mutant Mice Lacking the p53 C-Terminal Domain Model Telomere Syndromes
Cell Reports, 2013 Mutations in p53, although frequent in human cancers, have not been implicated in telomere-related syndromes. Here, we show that homozygous mutant mice expressing p53Δ31, a p53 lacking the C-terminal domain, exhibit increased p53 activity and suffer from
Iva Simeonova +12 more
doaj +1 more source
Fire, 2022 Changing global fire regimes including extended fire seasons due to climate change may increase the co-occurrence of high-impact fires that overwhelm national fire suppression capacities.
Sunniva Bloem +3 more
doaj +1 more source
Skill-Related Adaptive Modifications of Gaze Stabilization in Elite and Non-Elite Athletes
Frontiers in Sports and Active Living, 2022 The vestibular ocular reflex (VOR) provides gaze stability during head movements by driving eye movements in a direction opposing head motion. Although vestibular-based rehabilitation strategies are available, it is still unclear whether VOR can be ...
Susanne M. van der Veen +5 more
doaj +1 more source
Current Issues in Personality Psychology, 2022 Introduction Emotional complexity involves greater emotional awareness and understanding and associates strongly with adaptive emo-tion regulation. Similarly, regulation of emotion is vital for achieving, restoring, and sustaining subjective well-being ...
Satchit P. Mandal +3 more
doaj +1 more source
E6AP Promotes a Metastatic Phenotype in Prostate Cancer
iScience, 2019 Summary: Although primary prostate cancer is largely curable, progression to metastatic disease is associated with very poor prognosis. E6AP is an E3 ubiquitin ligase and a transcriptional co-factor involved in normal prostate development.
Cristina Gamell +22 more
doaj +1 more source
Measures of constitutional legal enforcement in the constitutional law of Brazil
Правоприменение, 2020 The subject. The article is devoted to different measures of constitutional legal enforcement in the constitutional law of Brazil, their analyzing, depending on main goal of coercion.The purpose of the paper is to extend constitutional knowledge about ...
Irina A. Tretyak
doaj +1 more source
Immune reactivity features in post-burn dynamics
RUDN Journal of Medicine, 2022 Relevance. To date, burn injury remains a complex type of damage to skin tissues. Along with local destructive and dystrophic phenomena, systemic changes in the body are observed.
Alfiya K. Azhikova +2 more
doaj +1 more source
Nature Communications, 2019 There is disproportionally high cancer prevalence in males. Here, the authors analyse the tumour suppressor p53 in sporadic cancers, highlighting a higher incidence of its mutation in males.
Sue Haupt +8 more
doaj +1 more source
Stem Cell Reports, 2017 Acquired genomic instability is one of the major concerns for the clinical use of induced pluripotent stem cells (iPSCs). All reprogramming methods are accompanied by the induction of DNA damage, of which double-strand breaks are the most cytotoxic and ...
Daniel Gómez-Cabello +4 more
doaj +1 more source
Frontiers in Psychology, 2021 The social adaptiveness of emotion regulation (ER) may differ across cultures due to different social values for the experience and expression of emotions. Specifically, suppression might disrupt social interactions among Germans, but not among Hong Kong
Fabian Schunk +3 more
doaj +1 more source