Results 31 to 40 of about 1,153,402 (263)
eLifeMissense ‘hotspot’ mutations localized in six p53 codons account for 20% of TP53 mutations in human cancers. Hotspot p53 mutants have lost the tumor suppressive functions of the wildtype protein, but whether and how they may gain additional functions ...
Sara Jaber +13 more
doaj +1 more source
A versatile drug delivery system targeting senescent cells
EMBO Molecular Medicine, 2018 Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent cells to design a ...
Daniel Muñoz‐Espín +18 more
doaj +1 more source
Fire, 2022 It is commonly assumed in fire modelling that suppression systems can control the heat release rate of a fire. However, many performance-based assumptions are derived from experimental data for sprinklers, and uncertainty remains for their application to
Charlie Hopkin +3 more
doaj +1 more source
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Юг России: экология, развитие, 2023 Aim. Assessment of the effect of biological products on soil suppression, biological efficacy, yield and biochemical parameters of potatoes in Krasnodar Territory.Material and Methods.
S. N. Nekoval', O. A. Maskalenko
doaj +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
FEBS Letters, EarlyView.Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho +3 more
wiley +1 more source
Clinical evidence supporting cranberry as a complementary approach to Helicobacter pylori management
Food Frontiers, 2020 This concise review summarizes results of the latest clinical trials that support the use of standardized cranberry juice intake as a complementary means of suppressing Helicobacter pylori infections.
Amy B. Howell
doaj +1 more source
Haunting across the Class Divide: Sarah Waters’s Affinity and The Little Stranger [PDF]
Avant, 2017 Haunting in literary fiction is often interpreted psychologically as a sign of suppressed psychic content or as nostalgia or mourning for the loss. Yet, it may also be used allegorically as a manifestation of hidden social conflicts, and hence mark a ...
Barbara Klonowska
doaj +1 more source
Pramana, 2003 Invited plenary talk presented on 4th International Conference on Physics and Astrophysics of Quark Gluon Plasma (ICPAQGP-2001), November 26-30, 2001, Jaipur; 12 pp, LaTeX, uses pramana ...
openaire +2 more sources