Results 21 to 30 of about 1,153,402 (263)
Stabilization of p21 by mTORC1/4E-BP1 predicts clinical outcome of head and neck cancers
Nature Communications, 2016 The molecular pathways involving p21 and mTORC1 are frequently deregulated in head and neck squamous cell carcinomas (HNSCC). Here, Llanos et al. report a mechanism that regulates p21 stability through the mTORC1/4E-BP1 pathway independently of p53, and ...
Susana Llanos +4 more
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Analysis of a Case of Supercellular Convection over Bulgaria: Observations and Numerical Simulations
Atmosphere, 2019 A long-lived supercell developed in Northwest Bulgaria on 15 May 2018 and inflicted widespread damage along its track. The first part of this article presents a detailed overview of the observed storm evolution. Doppler radar observations reveal that the
Hristo G. Chipilski +5 more
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WormBook, 2005 Genetic suppression has provided a very powerful tool for analyzing C. elegans. Suppression experiments are facilitated by the ability to handle very large numbers of individuals and to apply powerful selections. Because the animal grows as a self-fertilizing diploid, both dominant and recessive suppressors can be recovered.
openaire +2 more sources
Procedia Computer Science, 2013 AbstractGovernment agencies and large corporations meet similar problems related to control of agents dealing with outsiders: citizens under audit of the agency or clients of the company. In such interaction there typically exists a possibility of collusion.
Alexander Vasin +2 more
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eLifeThe Trp53 gene encodes several isoforms of elusive biological significance. Here, we show that mice lacking the Trp53 alternatively spliced (AS) exon, thereby expressing the canonical p53 protein but not isoforms with the AS C-terminus, have unexpectedly
Anne Fajac +14 more
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Frontiers in Psychology, 2019 BackgroundThe function of emotions, beginning from the proto-emotions, is the adaptation to the environment. This is based on the Homeorhesis, the equilibrium due to the adaptive operation of excitement and the dissipation of emotions.
Salvatore Settineri +5 more
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Background Therapeutic apheresis (TA) is an established treatment modality for hematologic, neurologic, and immunologic disorders, yet access remains severely limited in sub‐Saharan Africa. Donor apheresis, including platelet apheresis collection from healthy donors, represents an important complementary modality supporting blood product ...
Nosa Bazuaye +33 more
wiley +1 more source
G6PD protects from oxidative damage and improves healthspan in mice
Nature Communications, 2016 The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative ...
Sandrina Nóbrega-Pereira +7 more
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Therapeutic Apheresis and Dialysis, EarlyView.ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi +9 more
wiley +1 more source