Results 191 to 200 of about 2,809,202 (330)

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

CELL-MEDIATED PLATELET RECOGNITION BY LEUKOCYTES FROM INDIVIDUALS WITH AUTOIMMUNE THROMBOCYTOPENIA AND ITS SUPPRESSION BY HUMAN AND ANIMAL TRANSFER FACTOR [PDF]

, 1984
William Borkowsky, Simon Karpatkin
openalex   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Role of miR-138 in Cardiovascular Diseases. [PDF]

Biomed Res Int
Jiang T, Wang B, Luo Z, Xia Y, Qi Y, Luo S, Lang B, Zhang B, Zheng S.   +8 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Puberty suppression

Tidsskrift for Den norske legeforening
Atle, Fretheim, Anne Kveim, Lie, Ketil, Slagstad   +2 more
openaire   +2 more sources

Editorial: Materials for thermal safety enhancement in energy industries

Frontiers in Materials, 2023
Ying Zhang, Binbin Mao, Ming Yang, Kaihua Lu, Fuchao Tian   +4 more
doaj   +1 more source

Rubber voice illusion exposed neural correlates of voice perception and vocal adaptation across the continuum of psychosis. [PDF]

Sci Rep
Welp S, Hildelbrandt A, Magezi DA, Voss M, Kaltwasser L.   +4 more
europepmc   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Diagnostic performance of conventional fat-suppression T1WI versus fat-suppression 3D-T1WI-SPACE sequences in detecting glenoid labral injuries via direct shoulder MR arthrography. [PDF]

Eur J Med Res
Teng B, Wu H, Lin H.
europepmc   +1 more source