Results 31 to 40 of about 2,809,202 (330)

Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

eLife
The Trp53 gene encodes several isoforms of elusive biological significance. Here, we show that mice lacking the Trp53 alternatively spliced (AS) exon, thereby expressing the canonical p53 protein but not isoforms with the AS C-terminus, have unexpectedly
Anne Fajac, Iva Simeonova, Julia Leemput, Marc Gabriel, Aurélie Morin, Vincent Lejour, Annaïg Hamon, Jeanne Rakotopare, Wilhelm Vaysse-Zinkhöfer, Eliana Eldawra, Marina Pinskaya, Antonin Morillon, Jean-Christophe Bourdon, Boris Bardot, Franck Toledo   +14 more
doaj   +1 more source

Estimating the Suppression Performance of an Electronically Controlled Residential Water Mist System from BS 8458:2015 Fire Test Data

Fire, 2022
It is commonly assumed in fire modelling that suppression systems can control the heat release rate of a fire. However, many performance-based assumptions are derived from experimental data for sprinklers, and uncertainty remains for their application to
Charlie Hopkin, Michael Spearpoint, Yusuf Muhammad, William Makant   +3 more
doaj   +1 more source

Suppression of Density Fluctuations in a Quantum Degenerate Fermi Gas

, 2010
We study density profiles of an ideal Fermi gas and observe Pauli suppression of density fluctuations (atom shot noise) for cold clouds deep in the quantum degenerate regime.
Aviv Keshet, Christian Sanner, D. Pines, Edward J. Su, K. Helmerson, Ralf Gommers, T. Mueller, W. Ketterle, Wolfgang Ketterle, Wujie Huang, Y. Castin, Yong-il Shin   +11 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

G6PD protects from oxidative damage and improves healthspan in mice

Nature Communications, 2016
The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative ...
Sandrina Nóbrega-Pereira, Pablo J. Fernandez-Marcos, Thomas Brioche, Mari Carmen Gomez-Cabrera, Andrea Salvador-Pascual, Juana M. Flores, Jose Viña, Manuel Serrano   +7 more
doaj   +1 more source

Emotional Suppression and Oneiric Expression in Psychosomatic Disorders: Early Manifestations in Emerging Adulthood and Young Patients

Frontiers in Psychology, 2019
BackgroundThe function of emotions, beginning from the proto-emotions, is the adaptation to the environment. This is based on the Homeorhesis, the equilibrium due to the adaptive operation of excitement and the dissipation of emotions.
Salvatore Settineri, Fabio Frisone, Fabio Frisone, Angela Alibrandi, Emanuele Maria Merlo, Emanuele Maria Merlo   +5 more
doaj   +1 more source

Effect of the biological protection system on the composition of soil microbiota and quality of potatoes in the central agro‐climatic zone of Krasnodar Territory, Russia

Юг России: экология, развитие, 2023
Aim. Assessment of the effect of biological products on soil suppression, biological efficacy, yield and biochemical parameters of potatoes in Krasnodar Territory.Material and Methods.
S. N. Nekoval', O. A. Maskalenko
doaj   +1 more source

An engineered Tetrahymena tRNA(Gln) for in vivo incorporation of unnatural amino acids into proteins by nonsense suppression [PDF]

, 1996
A new tRNA, THG73, has been designed and evaluated as a vehicle for incorporating unnatural amino acids site-specifically into proteins expressed in vivo using the stop codon suppression technique.
Abelson, John N., Dougherty, Dennis A., Du, Fangyong, Kearney, Patrick C., Lester, Henry A., Nowak, Mark W., Saks, Margaret E., Sampson, Jeffrey R.   +7 more
core   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C

eLife
Missense ‘hotspot’ mutations localized in six p53 codons account for 20% of TP53 mutations in human cancers. Hotspot p53 mutants have lost the tumor suppressive functions of the wildtype protein, but whether and how they may gain additional functions ...
Sara Jaber, Eliana Eldawra, Jeanne Rakotopare, Iva Simeonova, Vincent Lejour, Marc Gabriel, Tatiana Cañeque, Vitalina Volochtchouk, Monika Licaj, Anne Fajac, Raphaël Rodriguez, Antonin Morillon, Boris Bardot, Franck Toledo   +13 more
doaj   +1 more source