Results 51 to 60 of about 1,775,082 (265)

Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas

eLife
The Trp53 gene encodes several isoforms of elusive biological significance. Here, we show that mice lacking the Trp53 alternatively spliced (AS) exon, thereby expressing the canonical p53 protein but not isoforms with the AS C-terminus, have unexpectedly
Anne Fajac, Iva Simeonova, Julia Leemput, Marc Gabriel, Aurélie Morin, Vincent Lejour, Annaïg Hamon, Jeanne Rakotopare, Wilhelm Vaysse-Zinkhöfer, Eliana Eldawra, Marina Pinskaya, Antonin Morillon, Jean-Christophe Bourdon, Boris Bardot, Franck Toledo   +14 more
doaj   +1 more source

Topological suppression of magnetoconductance oscillations in NS junctions [PDF]

Phys. Status Solidi B: 1521-3951 (2017), 2017
We show that the magnetoconductance oscillations of laterally-confined 2D NS junctions are completely suppressed when the superconductor side enters a topological phase. This suppression can be attributed to the modification of the vortex structure of local currents at the junction caused by the topological transition of the superconductor.
arxiv   +1 more source

Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.

New England Journal of Medicine, 1991
BACKGROUND AND METHODS In the Cardiac Arrhythmia Suppression Trial, designed to test the hypothesis that suppression of ventricular ectopy after a myocardial infarction reduces the incidence of sudden death, patients in whom ventricular ectopy could be ...
D. Echt, P. Liebson, L. Mitchell, R. Peters, D. Obias-Manno, A. H. Barker, D. Arensberg, A. Baker, Lawrence M. Friedman, H. Greene, M. Huther, D. Richardson   +11 more
semanticscholar   +1 more source

Tactile suppression of displacement [PDF]

Experimental Brain Research, 2010
In vision, the discovery of the phenomenon of saccadic suppression of displacement has made important contributions to the understanding of the stable world problem. Here, we report a similar phenomenon in the tactile modality. When scanning a single Braille dot with two fingers of the same hand, participants were asked to decide whether the dot was ...
Ziat, Mounia, Hayward, Vincent, Chapman, C. Elaine, Ernst, Marc, Lenay, Charles   +4 more
openaire   +6 more sources

G6PD protects from oxidative damage and improves healthspan in mice

Nature Communications, 2016
The enzyme G6PD generates the reductive metabolite NADPH, which has antioxidant effects, but has also been linked to tumour growth. Here the authors generate mice that modestly overexpress G6PD and report increased lifespan in females, and no negative ...
Sandrina Nóbrega-Pereira, Pablo J. Fernandez-Marcos, Thomas Brioche, Mari Carmen Gomez-Cabrera, Andrea Salvador-Pascual, Juana M. Flores, Jose Viña, Manuel Serrano   +7 more
doaj   +1 more source

BAP1 links metabolic regulation of ferroptosis to tumor suppression

Nature Cell Biology, 2018
The roles and regulatory mechanisms of ferroptosis (a non-apoptotic form of cell death) in cancer remain unclear. The tumour suppressor BRCA1-associated protein 1 (BAP1) encodes a nuclear deubiquitinating enzyme to reduce histone 2A ubiquitination (H2Aub)
Yilei Zhang, Jiejun Shi, Xiaoguang Liu, Li Feng, Zihua Gong, Pranavi Koppula, Kapil Sirohi, Xu Li, Yongkun Wei, Hyemin Lee, L. Zhuang, Gang Chen, Zhen-Dong Xiao, M. Hung, Junjie Chen, Peng Huang, Wei Li, B. Gan   +17 more
semanticscholar   +1 more source

Pubertal Suppression for Transgender Youth and Risk of Suicidal Ideation

Pediatrics, 2020
According to a large cross-sectional survey of young transgender adults, access to pubertal suppression during adolescence is associated with lower odds of lifetime suicidal ideation.
J. Turban, D. King, J. Carswell, A. Keuroghlian   +3 more
semanticscholar   +1 more source

IT for Corruption Suppression

Procedia Computer Science, 2013
AbstractGovernment agencies and large corporations meet similar problems related to control of agents dealing with outsiders: citizens under audit of the agency or clients of the company. In such interaction there typically exists a possibility of collusion.
Anton Urazov, Pavel Nikolaev, Alexander Vasin   +2 more
openaire   +1 more source

Oncogenic and teratogenic effects of Trp53Y217C, an inflammation-prone mouse model of the human hotspot mutant TP53Y220C

eLife
Missense ‘hotspot’ mutations localized in six p53 codons account for 20% of TP53 mutations in human cancers. Hotspot p53 mutants have lost the tumor suppressive functions of the wildtype protein, but whether and how they may gain additional functions ...
Sara Jaber, Eliana Eldawra, Jeanne Rakotopare, Iva Simeonova, Vincent Lejour, Marc Gabriel, Tatiana Cañeque, Vitalina Volochtchouk, Monika Licaj, Anne Fajac, Raphaël Rodriguez, Antonin Morillon, Boris Bardot, Franck Toledo   +13 more
doaj   +1 more source

A versatile drug delivery system targeting senescent cells

EMBO Molecular Medicine, 2018
Senescent cells accumulate in multiple aging‐associated diseases, and eliminating these cells has recently emerged as a promising therapeutic approach. Here, we take advantage of the high lysosomal β‐galactosidase activity of senescent cells to design a ...
Daniel Muñoz‐Espín, Miguel Rovira, Irene Galiana, Cristina Giménez, Beatriz Lozano‐Torres, Marta Paez‐Ribes, Susana Llanos, Selim Chaib, Maribel Muñoz‐Martín, Alvaro C Ucero, Guillermo Garaulet, Francisca Mulero, Stephen G Dann, Todd VanArsdale, David J Shields, Andrea Bernardos, José Ramón Murguía, Ramón Martínez‐Máñez, Manuel Serrano   +18 more
doaj   +1 more source