Results 31 to 40 of about 694,789 (266)

Recoding of Nonsense Mutation as a Pharmacological Strategy

Biomedicines, 2023
Approximately 11% of genetic human diseases are caused by nonsense mutations that introduce a premature termination codon (PTC) into the coding sequence. The PTC results in the production of a potentially harmful shortened polypeptide and activation of a
Gazmend Temaj, Pelin Telkoparan-Akillilar, Nexhibe Nuhii, Silvia Chichiarelli, Sarmistha Saha, Luciano Saso   +5 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Performance Boundaries and Related Improvement Method of Sub-Oscillation- Suppression Capabilities in Continuously Adjustable Phase-Shifting Transformer

IEEE Access
The increasing penetration of power electronic devices has elevated the possibility of sub-synchronous oscillation (SSO) in the power grid. At the same time, the continuously adjustable phase-shifting transformer (CAPST) exhibits a certain capability for
Jinjiao Lin, Jingyan Du, Shi Chen, Xinying Wang, Haodong Long, Chuyang Wang   +5 more
doaj   +1 more source

Suppression of NF-κB Activity: A Viral Immune Evasion Mechanism

Viruses, 2018
Nuclear factor-κB (NF-κB) is an important transcription factor that induces the expression of antiviral genes and viral genes. NF-κB activation needs the activation of NF-κB upstream molecules, which include receptors, adaptor proteins, NF-κB (IκB ...
Liyao Deng, Qiurui Zeng, Mingshu Wang, Anchun Cheng, Renyong Jia, Shun Chen, Dekang Zhu, Mafeng Liu, Qiao Yang, Ying Wu, Xinxin Zhao, Shaqiu Zhang, Yunya Liu, Yanling Yu, Ling Zhang, Xiaoyue Chen   +15 more
doaj   +1 more source

Mechanism of suppression of insulin signalling with lignocaine [PDF]

British Journal of Pharmacology, 2002
Lignocaine suppresses insulin‐stimulated glucose transport into the cells and insulin‐stimulated glycogenesis at doses equivalent to that used in the treatment of muscle pain disorder. We evaluated the direct effect of lignocaine on insulin receptor (IR) kinase activity. After lignocaine (40 mM, approximately equivalent to 1%) or an equal volume (100 
Munetaka, Hirose, J A Jeevendra, Martyn, Yoshihiro, Kuroda, Yoshinori, Marunaka, Yoshifumi, Tanaka   +4 more
openaire   +2 more sources

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Comparative Study of the Suppression Behavior and Fire-Extinguishing Mechanism of Compressed-Gas Aqueous Film-Forming Foam in Diesel Pool Fires

Fire, 2023
A compressed-gas fire extinguishing experiment was carried out to analyze the impact of gas-liquid flow ratio, liquid flow rate and driving pressure on the fire suppression efficiency of aqueous film-forming foam (AFFF) in a diesel pool fire, and a ...
Long Yan, Ning Wang, Jingjing Guan, Zheng Wei, Qiaowei Xiao, Zhisheng Xu   +5 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Rotating Behavior Observation of Cavitation in Inducer with Suction Axi-Asymmetrical Plate

Journal of Fluid Science and Technology, 2008
The attachment of inducer in front of main impeller is a powerful method to improve cavitation performance. In operating condition at partial flow rate and extremely low suction pressure, cavitation surge oscillation occurs and the stable operating range
Jun-Ho KIM, Takashi ATONO, Koichi ISHIZAKA, Satoshi WATANABE, Akinori FURUKAWA   +4 more
doaj   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source