Results 41 to 50 of about 694,789 (266)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

A review of metal dust explosion characteristics and protection technologies

Journal of Safety and Sustainability
The research progress of metal dust explosion venting characteristics and its protection technology is expounded and summarized in this paper. Based on the summary of previous research, the main focus of current attention and the key scientific issues to
Yawei Lu, Xingyan Cao, Zhirong Wang, Shuo Xu, Shaochen Sun   +4 more
doaj   +1 more source

Linking Signal Relevancy and Intensity in Predictive Tactile Suppression

Frontiers in Human Neuroscience, 2022
Predictable somatosensory feedback leads to a reduction in tactile sensitivity. This phenomenon, called tactile suppression, relies on a mechanism that uses an efference copy of motor commands to help select relevant aspects of incoming sensory signals ...
Marie C. Beyvers, Lindsey E. Fraser, Lindsey E. Fraser, Katja Fiehler, Katja Fiehler   +4 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Mechanisms suppressing noncoding translation

Trends in Cell Biology
The majority of the DNA sequence in our genome is noncoding and not intended for synthesizing proteins. Nonetheless, genome-wide mapping of ribosome footprints has revealed widespread translation in annotated noncoding sequences, including long noncoding RNAs (lncRNAs), untranslated regions (UTRs), and introns of mRNAs.
Jordan S. Kesner, Xuebing Wu
openaire   +2 more sources

The Mechanism of ‘Knock’ Suppression [PDF]

Nature, 1927
THE letter by Messrs. Egerton and Gates in the issue of Mar. 19, p. 427, concerning the mechanism of ‘knock’ suppressors such as lead tetra-ethyl, prompts me to add certain points of view material to the discussion.
openaire   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Design and Optimization of a High-Frequency Oscillation Suppression Strategy for the Grid-Connected Inverter of a Permanent Magnet Direct Drive Wind Turbine

Energies
With the development of the new power system with a high proportion of new energy and a high proportion of power electronic equipment, various problems caused by high-frequency oscillation will seriously affect the daily normal operation of the power ...
Zhaoyang Liu, Yubo Yuan, Chuang Liu, Cong Sun, Zijun Bin   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Molecular mechanisms of tumor suppression by LKB1

FEBS Letters, 2010
The LKB1 tumor suppressor gene is frequently mutated in sporadic lung adenocarcinomas and cervical cancers and germline mutations are causative for Peutz-Jeghers syndrome characterized by gastrointestinal polyposis. The intracellular LKB1 kinase is implicated in regulating polarity, metabolism, cell differentiation, and proliferation - all functions ...
Vaahtomeri, Kari, Mäkelä, Tomi P.
openaire   +2 more sources