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Current Opinion in Genetics & Development, 1994
The mutation of tumor suppressor genes is thought to contribute to tumor growth by inactivating proteins that normally act to limit cell proliferation. Several tumor suppressor proteins have been identified in recent years, but only two of them, p53 and pRb, are understood in detail.
P W, Hinds, R A, Weinberg
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The mutation of tumor suppressor genes is thought to contribute to tumor growth by inactivating proteins that normally act to limit cell proliferation. Several tumor suppressor proteins have been identified in recent years, but only two of them, p53 and pRb, are understood in detail.
P W, Hinds, R A, Weinberg
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The International Journal of Biochemistry & Cell Biology, 2006
The ARF tumour suppressor is a product of the INK4a/ARF locus; a sequence that is frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical regulator of p53 stability through interactions with the mdm2 and ARF-BP1/Mule ubiquitin ligases. Cellular stress signals liberate ARF from the nucleolus where it is bound to B23/
Stuart J, Gallagher +2 more
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The ARF tumour suppressor is a product of the INK4a/ARF locus; a sequence that is frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical regulator of p53 stability through interactions with the mdm2 and ARF-BP1/Mule ubiquitin ligases. Cellular stress signals liberate ARF from the nucleolus where it is bound to B23/
Stuart J, Gallagher +2 more
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A Dominant Suppressor of A and B
Vox Sanguinis, 1973Abstract. A healthy blood donor was found to have no anti‐A in his serum while his red cells typed as O. A maternal half‐brother, whose father is not related, lacks anti‐B. The pedigree shows that the effect is due to dominant suppression of normal A1 and B genes.
P, Rubinstein +2 more
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Journal of Cell Science, 1988
ABSTRACT Genes that can inhibit the expression of the tumorigenic phenotype have been detected by the fusion of normal and malignant cells, the phenotypic reversion of in vitro transformants, the induction of terminal differentiation of malignant cell lineages, the loss of ‘recessive cancer genes’, the discovery of regulatory sequences ...
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ABSTRACT Genes that can inhibit the expression of the tumorigenic phenotype have been detected by the fusion of normal and malignant cells, the phenotypic reversion of in vitro transformants, the induction of terminal differentiation of malignant cell lineages, the loss of ‘recessive cancer genes’, the discovery of regulatory sequences ...
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SUPPRESSOR RECOMBINANTS AND SUPPRESSOR MUTANTS
1981Christoph Scholtissek, Susan B. Spring
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Mutations and mechanisms of WNT pathway tumour suppressors in cancer
Nature Reviews Cancer, 2020Madelon M Maurice +2 more
exaly
MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer
Cancer Cell, 2020Robert N Eisenman +2 more
exaly